Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1997 1
1998 4
1999 3
2000 5
2001 3
2002 3
2003 3
2004 5
2005 4
2006 10
2007 6
2008 19
2009 20
2010 30
2011 37
2012 55
2013 38
2014 44
2015 41
2016 39
2017 41
2018 45
2019 32
2020 34
2021 42
2022 35
2023 30
2024 11

Text availability

Article attribute

Article type

Publication date

Search Results

563 results

Results by year

Filters applied: . Clear all
Page 1
CYP4F2 is a human-specific determinant of circulating N-acyl amino acid levels.
Tanzo JT, Li VL, Wiggenhorn AL, Moya-Garzon MD, Wei W, Lyu X, Dong W, Tahir UA, Chen ZZ, Cruz DE, Deng S, Shi X, Zheng S, Guo Y, Sims M, Abu-Remaileh M, Wilson JG, Gerszten RE, Long JZ, Benson MD. Tanzo JT, et al. J Biol Chem. 2023 Jun;299(6):104764. doi: 10.1016/j.jbc.2023.104764. Epub 2023 Apr 28. J Biol Chem. 2023. PMID: 37121548 Free PMC article.
By integrating whole genome sequencing data with N-acyl amino acid levels, we identify that the genetic determinants of N-acyl amino acid levels also cluster according to the amino acid head group. Furthermore, we identify the CYP4F2 locus as a genetic determinant of plasm …
By integrating whole genome sequencing data with N-acyl amino acid levels, we identify that the genetic determinants of N-acyl amino acid le …
Influence of the CYP4F2 polymorphism on the risk of hemorrhagic complications in coumarin-treated patients.
Chen P, Sun YQ, Yang GP, Li R, Pan J, Zhou YS. Chen P, et al. Saudi Med J. 2016 Apr;37(4):361-8. doi: 10.15537/smj.2016.4.14036. Saudi Med J. 2016. PMID: 27052278 Free PMC article. Review.
OBJECTIVES: To evaluate the impact of the CYP4F2 polymorphism on bleeding complications and over-anticoagulation due to coumarin. ...We found a lower risk in patients with homozygotes for CYP4F2*3, but there was no statistical significance (RR: 0.66; 95% CI: 0.43-1. …
OBJECTIVES: To evaluate the impact of the CYP4F2 polymorphism on bleeding complications and over-anticoagulation due to coumarin. ... …
CYP4F2-Catalyzed Metabolism of Arachidonic Acid Promotes Stromal Cell-Mediated Immunosuppression in Non-Small Cell Lung Cancer.
Chen X, Liu Y, Wang Y, Wang C, Chen X, Xiong Y, Liu L, Yuan X, Tang H, Shu C, Zhang J, Guo AM, Chen H, Yang J. Chen X, et al. Cancer Res. 2022 Nov 2;82(21):4016-4030. doi: 10.1158/0008-5472.CAN-21-4029. Cancer Res. 2022. PMID: 36006988
The identification of a role for CYP4F2-dependent metabolism in driving immune evasion in non-small cell lung cancer reveals a strategy to improve the efficacy of immunotherapy by inhibiting CYP4F2. ...
The identification of a role for CYP4F2-dependent metabolism in driving immune evasion in non-small cell lung cancer reveals a strate …
CYP4F2 and VKORC1 Polymorphisms Amplify the Risk of Carotid Plaque Formation.
Vesa SC, Vlaicu SI, Vacaras V, Crisan S, Sabin O, Pasca S, Trifa AP, Rusz-Fogarasi T, Sava M, Buzoianu AD. Vesa SC, et al. Genes (Basel). 2020 Jul 20;11(7):822. doi: 10.3390/genes11070822. Genes (Basel). 2020. PMID: 32698322 Free PMC article.
VKORC1 and CYP4F2 polymorphisms did not predict plaque formation, except for VKORC1 homozygous mutants. Nonetheless, both VKORC1 and CYP4F2 interacted with ischemic cardiac disease, increasing the risk of developing a carotid plaque, while only CYP4F2, but no …
VKORC1 and CYP4F2 polymorphisms did not predict plaque formation, except for VKORC1 homozygous mutants. Nonetheless, both VKORC1 and …
Effect of CYP4F2 Polymorphisms on Ticagrelor Pharmacokinetics in Healthy Chinese Volunteers.
Nie S, Chen K, Guo C, Pei Q, Zou C, Yao L, Yuan H, Zhao X, Xie R, He X, Huang J, Yang G. Nie S, et al. Front Pharmacol. 2022 Feb 25;12:797278. doi: 10.3389/fphar.2021.797278. eCollection 2021. Front Pharmacol. 2022. PMID: 35280252 Free PMC article.

Healthy volunteers enrolled in the fasting trial exhibited higher C (max)/W (p < 0.001) and AUC/W (p < 0.01), shorter T (max) (p < 0.001), and lower CL/F (p < 0.001) and V (d)/F (p < 0.001) than those enrolled in the fed trial. Upon confirmation through multivariat

…

Healthy volunteers enrolled in the fasting trial exhibited higher C (max)/W (p < 0.001) and AUC/W (p < 0.01), shorter T (max) (p <

…
CYP4F2 is a human-specific determinant of circulating N-acyl amino acid levels.
Tanzo JT, Li VL, Wiggenhorn AL, Moya-Garzon MD, Wei W, Lyu X, Dong W, Tahir UA, Chen ZZ, Cruz DE, Deng S, Shi X, Zheng S, Guo Y, Sims M, Abu-Remaileh M, Wilson JG, Gerszten RE, Long JZ, Benson MD. Tanzo JT, et al. bioRxiv [Preprint]. 2023 Mar 9:2023.03.09.531581. doi: 10.1101/2023.03.09.531581. bioRxiv. 2023. PMID: 36945562 Free PMC article. Updated. Preprint.
N-oleoyl-leucine and N-oleoyl-phenylalanine were positively associated with traits related to energy balance, including body mass index, waist circumference, and subcutaneous adipose tissue. In addition, we identify the CYP4F2 locus as a human-specific genetic determinant …
N-oleoyl-leucine and N-oleoyl-phenylalanine were positively associated with traits related to energy balance, including body mass index, wai …
PharmGKB summary: very important pharmacogene information for CYP4F2.
Alvarellos ML, Sangkuhl K, Daneshjou R, Whirl-Carrillo M, Altman RB, Klein TE. Alvarellos ML, et al. Pharmacogenet Genomics. 2015 Jan;25(1):41-7. doi: 10.1097/FPC.0000000000000100. Pharmacogenet Genomics. 2015. PMID: 25370453 Free PMC article. Review. No abstract available.
CYP4F2 and CYP3A5 gene polymorphisms and lung cancer in Chinese Han population.
He R, Li M, Li A, Dang W, Yang T, Li J, Zhang N, Jin T, Chen M. He R, et al. Clin Exp Med. 2020 Aug;20(3):461-468. doi: 10.1007/s10238-020-00631-6. Epub 2020 Apr 30. Clin Exp Med. 2020. PMID: 32350633 Free PMC article.
This study aimed to explore whether the polymorphisms of CYP4F2 and CYP3A5 are correlated with the risk of lung cancer development. ...Stratified analysis found that the rs3093105 and rs3093106 loci of CYP4F2 gene were significantly associated with lower risk of lun …
This study aimed to explore whether the polymorphisms of CYP4F2 and CYP3A5 are correlated with the risk of lung cancer development. . …
Impact of the CYP4F2 p.V433M polymorphism on coumarin dose requirement: systematic review and meta-analysis.
Danese E, Montagnana M, Johnson JA, Rettie AE, Zambon CF, Lubitz SA, Suarez-Kurtz G, Cavallari LH, Zhao L, Huang M, Nakamura Y, Mushiroda T, Kringen MK, Borgiani P, Ciccacci C, Au NT, Langaee T, Siguret V, Loriot MA, Sagreiya H, Altman RB, Shahin MH, Scott SA, Khalifa SI, Chowbay B, Suriapranata IM, Teichert M, Stricker BH, Taljaard M, Botton MR, Zhang JE, Pirmohamed M, Zhang X, Carlquist JF, Horne BD, Lee MT, Pengo V, Guidi GC, Minuz P, Fava C. Danese E, et al. Clin Pharmacol Ther. 2012 Dec;92(6):746-56. doi: 10.1038/clpt.2012.184. Epub 2012 Nov 7. Clin Pharmacol Ther. 2012. PMID: 23132553 Free PMC article. Review.
A systematic review and a meta-analysis were performed to quantify the accumulated information from genetic association studies investigating the impact of the CYP4F2 rs2108622 (p.V433M) polymorphism on coumarin dose requirement. An additional aim was to explore the contri …
A systematic review and a meta-analysis were performed to quantify the accumulated information from genetic association studies investigatin …
Genetic variants in CYP4F2 were significantly correlated with susceptibility to ischemic stroke.
Wu Y, Zhao J, Zhao Y, Huang T, Ma X, Pang H, Zhang M. Wu Y, et al. BMC Med Genet. 2019 Sep 11;20(1):155. doi: 10.1186/s12881-019-0888-6. BMC Med Genet. 2019. PMID: 31510945 Free PMC article.
However, the role of Cytochrome P450 family 4 subfamily F member 2 (CYP4F2) gene in IS remains unknown. Our study aimed to explore whether CYP4F2 polymorphisms influenced IS risk in the Han Chinese population. ...And, CYP4F2 gene may be involved in the develo …
However, the role of Cytochrome P450 family 4 subfamily F member 2 (CYP4F2) gene in IS remains unknown. Our study aimed to explore wh …
563 results