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Page 1
Anticonvulsant drug hypersensitivity.
Galindo PA, Borja J, Gómez E, Mur P, Gudín M, García R, Encinas C, Romero G, Garrido JA, Cortina P, Feo F. Galindo PA, et al. J Investig Allergol Clin Immunol. 2002;12(4):299-304. J Investig Allergol Clin Immunol. 2002. PMID: 12926190 Clinical Trial.
HLA-B*57:01/Carbamazepine-10,11-Epoxide Association Triggers Upregulation of the NFκB and JAK/STAT Pathways.
Haukamp FJ, Hartmann ZM, Pich A, Kuhn J, Blasczyk R, Stieglitz F, Bade-Döding C. Haukamp FJ, et al. Cells. 2023 Feb 21;12(5):676. doi: 10.3390/cells12050676. Cells. 2023. PMID: 36899812 Free PMC article.
Despite extensive clinical trials prior to the license of a specific drug, certain patient-specific immune reactions cannot be reliably predicted. The need for acknowledgement of the actual proteomic state for selected individuals under drug administration becomes obvious. …
Despite extensive clinical trials prior to the license of a specific drug, certain patient-specific immune reactions cannot be reliably p …
HLA-A 31:01 and HLA-B 15:02 as genetic markers for carbamazepine hypersensitivity in children.
Amstutz U, Ross CJ, Castro-Pastrana LI, Rieder MJ, Shear NH, Hayden MR, Carleton BC; CPNDS Consortium. Amstutz U, et al. Clin Pharmacol Ther. 2013 Jul;94(1):142-9. doi: 10.1038/clpt.2013.55. Epub 2013 Mar 18. Clin Pharmacol Ther. 2013. PMID: 23588310 Free PMC article.
Human leukocyte antigen-B (HLA)-B 15:02 and HLA-A 31:01 have been identified as predictive genetic markers for CBZ hypersensitivity in Asian and European patients. ...This study is the first to demonstrate the association of HLA-A 31:01 with CBZ hypersensitivity in childre …
Human leukocyte antigen-B (HLA)-B 15:02 and HLA-A 31:01 have been identified as predictive genetic markers for CBZ hypersensitivity i …
Pharmacogenetic determinants of immediate and delayed reactions of drug hypersensitivity.
Guéant JL, Guéant-Rodriguez RM, Gastin IA, Cornejo-García JA, Viola M, Barbaud A, Mertes PM, Blanca M, Romano A. Guéant JL, et al. Curr Pharm Des. 2008;14(27):2770-7. doi: 10.2174/138161208786369795. Curr Pharm Des. 2008. PMID: 18991696 Review.
In the future, identification of genetic predictors will benefit from genomewide association studies that also take ethnic differences into account. Ideally, predictors will help to prevent adverse reactions, as suggested by a recent study on the effectiveness of pr …
In the future, identification of genetic predictors will benefit from genomewide association studies that also take ethnic difference …
Carbamazepine-induced severe cutaneous adverse reactions and HLA genotypes in Koreans.
Kim SH, Lee KW, Song WJ, Kim SH, Jee YK, Lee SM, Kang HR, Park HW, Cho SH, Park SH, Min KU, Chang YS; Adverse Drug Reaction Research Group in Korea. Kim SH, et al. Epilepsy Res. 2011 Nov;97(1-2):190-7. doi: 10.1016/j.eplepsyres.2011.08.010. Epub 2011 Sep 13. Epilepsy Res. 2011. PMID: 21917426
The frequencies of B*1511 in carbamazepine-SJS and A*3101 in carbamazepine-HSS/SCAR were significantly higher than those in the general population. CONCLUSIONS: HLA-B*1502 does not seem to be an effective predictive marker for carbamazepine-induced SCAR, while HLA-B*1511 a …
The frequencies of B*1511 in carbamazepine-SJS and A*3101 in carbamazepine-HSS/SCAR were significantly higher than those in the general popu …
Genetic variation in CFH predicts phenytoin-induced maculopapular exanthema in European-descent patients.
McCormack M, Gui H, Ingason A, Speed D, Wright GEB, Zhang EJ, Secolin R, Yasuda C, Kwok M, Wolking S, Becker F, Rau S, Avbersek A, Heggeli K, Leu C, Depondt C, Sills GJ, Marson AG, Auce P, Brodie MJ, Francis B, Johnson MR, Koeleman BPC, Striano P, Coppola A, Zara F, Kunz WS, Sander JW, Lerche H, Klein KM, Weckhuysen S, Krenn M, Gudmundsson LJ, Stefánsson K, Krause R, Shear N, Ross CJD, Delanty N; EPIGEN Consortium;; Pirmohamed M, Carleton BC; Canadian Pharmacogenomics Network for Drug Safety;; Cendes F, Lopes-Cendes I, Liao WP, O'Brien TJ, Sisodiya SM; EpiPGX Consortium;; Cherny S, Kwan P, Baum L; International League Against Epilepsy Consortium on Complex Epilepsies;; Cavalleri GL. McCormack M, et al. Neurology. 2018 Jan 23;90(4):e332-e341. doi: 10.1212/WNL.0000000000004853. Epub 2017 Dec 29. Neurology. 2018. PMID: 29288229 Free PMC article.
OBJECTIVE: To characterize, among European and Han Chinese populations, the genetic predictors of maculopapular exanthema (MPE), a cutaneous adverse drug reaction common to antiepileptic drugs. ...We did not identify significant genetic associations with MPE among Han Chin …
OBJECTIVE: To characterize, among European and Han Chinese populations, the genetic predictors of maculopapular exanthema (MPE), a cu …
A nested sequence-specific primer-polymerase chain reaction for the detection of HLA-B*15:02.
Virakul S, Kupatawintu P, Nakkuntod J, Kangwanshiratada O, Vilaivan T, Hirankarn N. Virakul S, et al. Tissue Antigens. 2012 Apr;79(4):295-301. doi: 10.1111/j.1399-0039.2012.01836.x. Epub 2012 Jan 28. Tissue Antigens. 2012. PMID: 22283394
In this study, we reported a new technique in detecting HLA-B*15:02 by using a nested sequence-specific primer-polymerase chain reaction (SSP-PCR) that can be used on genomic DNA and whole blood for carbamazepine hypersensitivity prediction. We tested a total of 200 blind …
In this study, we reported a new technique in detecting HLA-B*15:02 by using a nested sequence-specific primer-polymerase chain reaction (SS …
Genetic analysis of microsomal epoxide hydrolase in patients with carbamazepine hypersensitivity.
Green VJ, Pirmohamed M, Kitteringham NR, Gaedigk A, Grant DM, Boxer M, Burchell B, Park BK. Green VJ, et al. Biochem Pharmacol. 1995 Oct 26;50(9):1353-9. doi: 10.1016/0006-2952(95)02009-8. Biochem Pharmacol. 1995. PMID: 7503783
The aim of this study was to determine whether a single genetic mutation or pattern of mutations could be used to predict individual susceptibility to carbamazepine-hypersensitivity. ...
The aim of this study was to determine whether a single genetic mutation or pattern of mutations could be used to predict individual …
Eosinophilic leukemoid reaction associated with carbamazepine hypersensitivity.
Laad G, Miranda MF. Laad G, et al. Indian J Dermatol Venereol Leprol. 2005 Jan-Feb;71(1):35-7. doi: 10.4103/0378-6323.13784. Indian J Dermatol Venereol Leprol. 2005. PMID: 16394359
Several adverse drug reactions have been described during the course of carbamazepine administration, including exanthemata and hematological reactions. ...
Several adverse drug reactions have been described during the course of carbamazepine administration, including exanthemata and hemat …
Validation of a novel real-time PCR assay for detection of HLA-B*15:02 allele for prevention of carbamazepine - Induced Stevens-Johnson syndrome/Toxic Epidermal Necrolysis in individuals of Asian ancestry.
Nguyen DV, Vidal C, Chu HC, Do NT, Tran TT, Le HT, Fulton RB, Li J, Fernando SL. Nguyen DV, et al. Hum Immunol. 2016 Dec;77(12):1140-1146. doi: 10.1016/j.humimm.2016.08.010. Epub 2016 Aug 17. Hum Immunol. 2016. PMID: 27544047
The assay has a sensitivity of 100% (95% CI: 76.84-100.0%), a specificity of 100% (95% CI: 96.61-100%), a positive predictive value of 100% (95% CI: 76.84-100%) and a negative predictive value of 100.0% (95% CI: 96.61-100.0%), respectively. ...
The assay has a sensitivity of 100% (95% CI: 76.84-100.0%), a specificity of 100% (95% CI: 96.61-100%), a positive predictive value o …