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1975 3
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617 results

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Quoted phrase not found in phrase index: "Cardiomyopathy, mitochondrial"
Page 1
Basic Mechanisms of Diabetic Heart Disease.
Ritchie RH, Abel ED. Ritchie RH, et al. Circ Res. 2020 May 22;126(11):1501-1525. doi: 10.1161/CIRCRESAHA.120.315913. Epub 2020 May 21. Circ Res. 2020. PMID: 32437308 Free PMC article. Review.
Diabetes mellitus predisposes affected individuals to a significant spectrum of cardiovascular complications, one of the most debilitating in terms of prognosis is heart failure. Indeed, the increasing global prevalence of diabetes mellitus and an aging population has give …
Diabetes mellitus predisposes affected individuals to a significant spectrum of cardiovascular complications, one of the most debilitating i …
Heart Failure in Type 2 Diabetes Mellitus.
Kenny HC, Abel ED. Kenny HC, et al. Circ Res. 2019 Jan 4;124(1):121-141. doi: 10.1161/CIRCRESAHA.118.311371. Circ Res. 2019. PMID: 30605420 Free PMC article. Review.
Beyond the structural and functional changes that characterize diabetic cardiomyopathy, a complex underlying, and interrelated pathophysiology exists. ...Dysregulation of many cellular mechanisms in multiple models of diabetic cardiomyopathy and in human hearts have …
Beyond the structural and functional changes that characterize diabetic cardiomyopathy, a complex underlying, and interrelated pathop …
Mitochondrial cardiomyopathy: pathophysiology, diagnosis, and management.
Meyers DE, Basha HI, Koenig MK. Meyers DE, et al. Tex Heart Inst J. 2013;40(4):385-94. Tex Heart Inst J. 2013. PMID: 24082366 Free PMC article. Review.
Mitochondrial disease is a heterogeneous group of multisystemic diseases that develop consequent to mutations in nuclear or mitochondrial DNA. ...In this review, we describe the complex pathophysiology of mitochondrial disease and its clinical features. We fo …
Mitochondrial disease is a heterogeneous group of multisystemic diseases that develop consequent to mutations in nuclear or mitoch …
Mitochondrial ROS in myocardial ischemia reperfusion and remodeling.
Bugger H, Pfeil K. Bugger H, et al. Biochim Biophys Acta Mol Basis Dis. 2020 Jul 1;1866(7):165768. doi: 10.1016/j.bbadis.2020.165768. Epub 2020 Mar 12. Biochim Biophys Acta Mol Basis Dis. 2020. PMID: 32173461 Free article. Review.
Both during ischemia reperfusion (IR) in the acute setting of MI, as well as in the chronic remodeling process following MI, oxidative stress substantially contributes to cardiac damage. Reactive oxygen species (ROS) generated within mitochondria are particular drivers of …
Both during ischemia reperfusion (IR) in the acute setting of MI, as well as in the chronic remodeling process following MI, oxidative stres …
Expert consensus document: Mitochondrial function as a therapeutic target in heart failure.
Brown DA, Perry JB, Allen ME, Sabbah HN, Stauffer BL, Shaikh SR, Cleland JG, Colucci WS, Butler J, Voors AA, Anker SD, Pitt B, Pieske B, Filippatos G, Greene SJ, Gheorghiade M. Brown DA, et al. Nat Rev Cardiol. 2017 Apr;14(4):238-250. doi: 10.1038/nrcardio.2016.203. Epub 2016 Dec 22. Nat Rev Cardiol. 2017. PMID: 28004807 Free PMC article. Review.
Mitochondrial abnormalities include impaired mitochondrial electron transport chain activity, increased formation of reactive oxygen species, shifted metabolic substrate utilization, aberrant mitochondrial dynamics, and altered ion homeostasis. In this Consen …
Mitochondrial abnormalities include impaired mitochondrial electron transport chain activity, increased formation of reactive …
Pearson syndrome: a multisystem mitochondrial disease with bone marrow failure.
Yoshimi A, Ishikawa K, Niemeyer C, Grünert SC. Yoshimi A, et al. Orphanet J Rare Dis. 2022 Oct 17;17(1):379. doi: 10.1186/s13023-022-02538-9. Orphanet J Rare Dis. 2022. PMID: 36253820 Free PMC article. Review.
Pearson syndrome (PS) is a rare fatal mitochondrial disorder caused by single large-scale mitochondrial DNA deletions (SLSMDs). ...In the absence of curative therapy, the prognosis of patients with PS is dismal. Most patients die of acute lactic acidosis and …
Pearson syndrome (PS) is a rare fatal mitochondrial disorder caused by single large-scale mitochondrial DNA deletions (SLSMDs) …
Congenital Titinopathy: Comprehensive characterization and pathogenic insights.
Oates EC, Jones KJ, Donkervoort S, Charlton A, Brammah S, Smith JE 3rd, Ware JS, Yau KS, Swanson LC, Whiffin N, Peduto AJ, Bournazos A, Waddell LB, Farrar MA, Sampaio HA, Teoh HL, Lamont PJ, Mowat D, Fitzsimons RB, Corbett AJ, Ryan MM, O'Grady GL, Sandaradura SA, Ghaoui R, Joshi H, Marshall JL, Nolan MA, Kaur S, Punetha J, Töpf A, Harris E, Bakshi M, Genetti CA, Marttila M, Werlauff U, Streichenberger N, Pestronk A, Mazanti I, Pinner JR, Vuillerot C, Grosmann C, Camacho A, Mohassel P, Leach ME, Foley AR, Bharucha-Goebel D, Collins J, Connolly AM, Gilbreath HR, Iannaccone ST, Castro D, Cummings BB, Webster RI, Lazaro L, Vissing J, Coppens S, Deconinck N, Luk HM, Thomas NH, Foulds NC, Illingworth MA, Ellard S, McLean CA, Phadke R, Ravenscroft G, Witting N, Hackman P, Richard I, Cooper ST, Kamsteeg EJ, Hoffman EP, Bushby K, Straub V, Udd B, Ferreiro A, North KN, Clarke NF, Lek M, Beggs AH, Bönnemann CG, MacArthur DG, Granzier H, Davis MR, Laing NG. Oates EC, et al. Ann Neurol. 2018 Jun;83(6):1105-1124. doi: 10.1002/ana.25241. Ann Neurol. 2018. PMID: 29691892 Free PMC article.
Cardiac involvement was present in 46% of patients. Relatives of 2 patients had dilated cardiomyopathy. Creatine kinase levels were normal to moderately elevated. ...One-third of patients had 1 mutation predicted to impact exons present in fetal skeletal muscle, but …
Cardiac involvement was present in 46% of patients. Relatives of 2 patients had dilated cardiomyopathy. Creatine kinase levels were n …
Pathogenetic mechanisms of septic cardiomyopathy.
Wang R, Xu Y, Fang Y, Wang C, Xue Y, Wang F, Cheng J, Ren H, Wang J, Guo W, Liu L, Zhang M. Wang R, et al. J Cell Physiol. 2022 Jan;237(1):49-58. doi: 10.1002/jcp.30527. Epub 2021 Jul 18. J Cell Physiol. 2022. PMID: 34278573 Review.
It is an important cause of death in critically ill patients who suffered an infection. Sepsis cardiomyopathy is a common complication that exacerbates the prognosis of patients. ...This article reviews mitochondrial dysfunction, mitophagy, oxidation stress, …
It is an important cause of death in critically ill patients who suffered an infection. Sepsis cardiomyopathy is a common complicatio …
Identification of Crucial Genes and Key Functions in Type 2 Diabetic Hearts by Bioinformatic Analysis.
Huang X, Zhang KJ, Jiang JJ, Jiang SY, Lin JB, Lou YJ. Huang X, et al. Front Endocrinol (Lausanne). 2022 Feb 15;13:801260. doi: 10.3389/fendo.2022.801260. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 35242109 Free PMC article.
There were 74 overlapping homologous DEGs among all datasets. Mitochondria inner membrane and serine-type endopeptidase activity were further identified as the top-10 GO events for overlapping DEGs. ...Therefore, attenuated cardiac CAPNS1 transcription in T2D patients with …
There were 74 overlapping homologous DEGs among all datasets. Mitochondria inner membrane and serine-type endopeptidase activity were …
Inflammation and metabolic cardiomyopathy.
Nishida K, Otsu K. Nishida K, et al. Cardiovasc Res. 2017 Mar 15;113(4):389-398. doi: 10.1093/cvr/cvx012. Cardiovasc Res. 2017. PMID: 28395010 Review.
In the early stage of metabolic cardiomyopathy, metabolic disturbance is not accompanied by substantial changes in myocardial structure and cardiac function. ...This review discusses some recent advances in understanding involvement of inflammation in metabolic cardiomy …
In the early stage of metabolic cardiomyopathy, metabolic disturbance is not accompanied by substantial changes in myocardial structu …
617 results