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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1980 1
1982 2
1983 1
1985 1
1986 1
1987 3
1988 1
1989 2
1990 1
1991 3
1992 3
1993 1
1994 3
1995 2
1996 3
1997 2
1998 5
1999 3
2000 8
2001 8
2002 8
2003 7
2004 14
2005 2
2006 7
2007 7
2008 9
2009 16
2010 8
2011 12
2012 12
2013 14
2014 10
2015 5
2016 18
2017 18
2018 8
2019 16
2020 13
2021 16
2022 18
2023 19
2024 9

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280 results

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Page 1
METTL3-mediated m6A modification of ATG7 regulates autophagy-GATA4 axis to promote cellular senescence and osteoarthritis progression.
Chen X, Gong W, Shao X, Shi T, Zhang L, Dong J, Shi Y, Shen S, Qin J, Jiang Q, Guo B. Chen X, et al. Ann Rheum Dis. 2022 Jan;81(1):87-99. doi: 10.1136/annrheumdis-2021-221091. Epub 2021 Oct 27. Ann Rheum Dis. 2022. PMID: 34706873
Re-establishment of autophagy reversed the senescent phenotype by suppressing GATA4. Further, we observed for the first time that excessive m(6)A modification negatively regulated autophagy in OA-FLS. ...Intra-articular injection of synovium-targeted METTL3 siRNA suppresse …
Re-establishment of autophagy reversed the senescent phenotype by suppressing GATA4. Further, we observed for the first time that exc …
Biomarkers for the diagnosis and treatment of rheumatoid arthritis - a systematic review.
Abdelhafiz D, Baker T, Glascow DA, Abdelhafiz A. Abdelhafiz D, et al. Postgrad Med. 2023 Apr;135(3):214-223. doi: 10.1080/00325481.2022.2052626. Epub 2022 Mar 16. Postgrad Med. 2023. PMID: 35275765 Review.
Anti-CCP, CRP 0.3 mg/dL, and RF predicted bone erosion and cartilage destruction. Combination of high 14-3-3eta protein with RF and CRP improved the prediction of rapid erosion progression (REP). ...The MBDA score was able to differentiate betwe …
Anti-CCP, CRP 0.3 mg/dL, and RF predicted bone erosion and cartilage destruction. Combination of high 14-3-3eta protein …
Gsmtx4 Alleviated Osteoarthritis through Piezo1/Calcineurin/NFAT1 Signaling Axis under Excessive Mechanical Strain.
Ren X, Zhuang H, Li B, Jiang F, Zhang Y, Zhou P. Ren X, et al. Int J Mol Sci. 2023 Feb 16;24(4):4022. doi: 10.3390/ijms24044022. Int J Mol Sci. 2023. PMID: 36835440 Free PMC article.
Excessive mechanical strain is the prominent risk factor for osteoarthritis (OA), causing cartilage destruction and degeneration. However, the underlying molecular mechanism contributing to mechanical signaling transduction remains unclear in OA. ...In vivo, Gsmtx4, …
Excessive mechanical strain is the prominent risk factor for osteoarthritis (OA), causing cartilage destruction and degenerati …
Development and validation of cuproptosis-related genes in synovitis during osteoarthritis progress.
Chang B, Hu Z, Chen L, Jin Z, Yang Y. Chang B, et al. Front Immunol. 2023 Feb 2;14:1090596. doi: 10.3389/fimmu.2023.1090596. eCollection 2023. Front Immunol. 2023. PMID: 36817415 Free PMC article.
Osteoarthritis (OA) is one of the most common refractory degenerative joint diseases worldwide. Synovitis is believed to drive joint cartilage destruction during OA pathogenesis. Cuproptosis is a novel form of copper-induced cell death. ...The expression of CRGs dif …
Osteoarthritis (OA) is one of the most common refractory degenerative joint diseases worldwide. Synovitis is believed to drive joint cart …
Nanotherapeutics relieve rheumatoid arthritis.
Yang M, Feng X, Ding J, Chang F, Chen X. Yang M, et al. J Control Release. 2017 Apr 28;252:108-124. doi: 10.1016/j.jconrel.2017.02.032. Epub 2017 Feb 28. J Control Release. 2017. PMID: 28257989 Review.
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease associated with persistent multiarticular synovitis, cartilage destruction, and even loss of joint function. Although remarkable progress has been made in the clinical treatment of RA, long-term …
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease associated with persistent multiarticular synovitis, cartilage …
Clinical prediction models of rheumatoid arthritis and its complications: focus on cardiovascular disease and interstitial lung disease.
Shao Y, Zhang H, Shi Q, Wang Y, Liang Q. Shao Y, et al. Arthritis Res Ther. 2023 Sep 1;25(1):159. doi: 10.1186/s13075-023-03140-5. Arthritis Res Ther. 2023. PMID: 37658422 Free PMC article. Review.
Its basic pathological changes are the formation of synovitis, and patients gradually develop destruction of articular cartilage destruction and bone erosion, which eventually leads to joint deformity, disability, and various extra-articular manifestations. Clinical …
Its basic pathological changes are the formation of synovitis, and patients gradually develop destruction of articular cartilage d …
Serpins in cartilage and osteoarthritis: what do we know?
Wilkinson DJ. Wilkinson DJ. Biochem Soc Trans. 2021 Apr 30;49(2):1013-1026. doi: 10.1042/BST20201231. Biochem Soc Trans. 2021. PMID: 33843993 Free PMC article. Review.
This breakdown of the cartilage is driven by the metalloproteinases, and it has long been established that an imbalance of metalloproteinases to their inhibitors is of critical importance. More recently, a role for serine proteinases in cartilage destruction is emer …
This breakdown of the cartilage is driven by the metalloproteinases, and it has long been established that an imbalance of metalloproteinase …
Vitamin D Deficiency and Rheumatoid Arthritis.
Ishikawa LLW, Colavite PM, Fraga-Silva TFC, Mimura LAN, França TGD, Zorzella-Pezavento SFG, Chiuso-Minicucci F, Marcolino LD, Penitenti M, Ikoma MRV, Sartori A. Ishikawa LLW, et al. Clin Rev Allergy Immunol. 2017 Jun;52(3):373-388. doi: 10.1007/s12016-016-8577-0. Clin Rev Allergy Immunol. 2017. PMID: 27484684 Review.
Rheumatoid arthritis (RA) is a chronic inflammatory systemic autoimmune disease that compromises the joints, causing cartilage destruction and bone erosion. RA treatment usually consists of combined therapies that generally suppress the entire immune response leadin …
Rheumatoid arthritis (RA) is a chronic inflammatory systemic autoimmune disease that compromises the joints, causing cartilage des …
Osteopontin: A Bone-Derived Protein Involved in Rheumatoid Arthritis and Osteoarthritis Immunopathology.
Martín-Márquez BT, Sandoval-García F, Corona-Meraz FI, Martínez-García EA, Sánchez-Hernández PE, Salazar-Páramo M, Fletes-Rayas AL, González-Inostroz D, Vazquez-Del Mercado M. Martín-Márquez BT, et al. Biomolecules. 2023 Mar 9;13(3):502. doi: 10.3390/biom13030502. Biomolecules. 2023. PMID: 36979437 Free PMC article. Review.
Therefore, it is an effector molecule that promotes joint and cartilage destruction observed in clinical studies, in vitro assays, and animal models of RA and OA. ...This review aims to provide evidence of the OPN's multifaceted role in promoting joint and …
Therefore, it is an effector molecule that promotes joint and cartilage destruction observed in clinical studies, in vi …
5-aminosalicylic acid suppresses osteoarthritis through the OSCAR-PPARγ axis.
Kim J, Ryu G, Seo J, Go M, Kim G, Yi S, Kim S, Lee H, Lee JY, Kim HS, Park MC, Shin DH, Shim H, Kim W, Lee SY. Kim J, et al. Nat Commun. 2024 Feb 3;15(1):1024. doi: 10.1038/s41467-024-45174-6. Nat Commun. 2024. PMID: 38310093 Free PMC article.
Osteoarthritis (OA) is a progressive and irreversible degenerative joint disease that is characterized by cartilage destruction, osteophyte formation, subchondral bone remodeling, and synovitis. ...Intra-articular 5-ASA injections ameliorate OA generated by surgery- …
Osteoarthritis (OA) is a progressive and irreversible degenerative joint disease that is characterized by cartilage destruction …
280 results