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Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1963 1
1967 4
1968 2
1970 1
1971 3
1972 1
1973 3
1974 1
1975 6
1976 5
1977 7
1978 10
1979 7
1980 10
1981 11
1982 13
1983 12
1984 16
1985 18
1986 18
1987 22
1988 20
1989 26
1990 25
1991 29
1992 29
1993 25
1994 27
1995 26
1996 30
1997 44
1998 45
1999 45
2000 41
2001 59
2002 62
2003 76
2004 88
2005 80
2006 73
2007 92
2008 112
2009 116
2010 123
2011 144
2012 147
2013 162
2014 162
2015 152
2016 133
2017 178
2018 190
2019 166
2020 172
2021 187
2022 182
2023 151
2024 55

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Search Results

3,205 results

Results by year

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Page 1
Caplacizumab Treatment for Acquired Thrombotic Thrombocytopenic Purpura.
Scully M, Cataland SR, Peyvandi F, Coppo P, Knöbl P, Kremer Hovinga JA, Metjian A, de la Rubia J, Pavenski K, Callewaert F, Biswas D, De Winter H, Zeldin RK; HERCULES Investigators. Scully M, et al. N Engl J Med. 2019 Jan 24;380(4):335-346. doi: 10.1056/NEJMoa1806311. Epub 2019 Jan 9. N Engl J Med. 2019. PMID: 30625070 Free article. Clinical Trial.
Key secondary outcomes included a composite of TTP-related death, recurrence of TTP, or a thromboembolic event during the trial treatment period; recurrence of TTP at any time during the trial; refractory TTP; and normalization of organ-damage markers. ...One patien …
Key secondary outcomes included a composite of TTP-related death, recurrence of TTP, or a thromboembolic event during the trial treat …
Effectiveness of Lumbar Cerebrospinal Fluid Drain Among Patients With Aneurysmal Subarachnoid Hemorrhage: A Randomized Clinical Trial.
Wolf S, Mielke D, Barner C, Malinova V, Kerz T, Wostrack M, Czorlich P, Salih F, Engel DC, Ehlert A, Staykov D, Alturki AY, Sure U, Bardutzky J, Schroeder HWS, Schürer L, Beck J, Juratli TA, Fritsch M, Lemcke J, Pohrt A, Meyer B, Schwab S, Rohde V, Vajkoczy P; EARLYDRAIN Study Group. Wolf S, et al. JAMA Neurol. 2023 Aug 1;80(8):833-842. doi: 10.1001/jamaneurol.2023.1792. JAMA Neurol. 2023. PMID: 37330974 Free PMC article. Clinical Trial.
DESIGN, SETTING, AND PARTICIPANTS: The EARLYDRAIN trial was a pragmatic, multicenter, parallel-group, open-label randomized clinical trial with blinded end point evaluation conducted at 19 centers in Germany, Switzerland, and Canada. ...A total of 20 …
DESIGN, SETTING, AND PARTICIPANTS: The EARLYDRAIN trial was a pragmatic, multicenter, parallel-group, open-label randomized …
Seizures, Status Epilepticus, and Continuous EEG in the Intensive Care Unit.
Rosenthal ES. Rosenthal ES. Continuum (Minneap Minn). 2021 Oct 1;27(5):1321-1343. doi: 10.1212/CON.0000000000001012. Continuum (Minneap Minn). 2021. PMID: 34618762 Review.
However, accepted definitions of seizures and nonconvulsive status epilepticus encourage a treatment trial when the diagnosis on EEG is indeterminate because of periodic or rhythmic patterns or uncertain clinical correlation. ...EEG has additionally been validated a …
However, accepted definitions of seizures and nonconvulsive status epilepticus encourage a treatment trial when the diagnosis on EEG …
A Comparison Between Enteral and Intravenous Nimodipine in Subarachnoid Hemorrhage: A Systematic Review and Network Meta-Analysis.
Geraldini F, De Cassai A, Diana P, Correale C, Boscolo A, Zampirollo S, Disarò L, Carere A, Cacco N, Navalesi P, Munari M. Geraldini F, et al. Neurocrit Care. 2022 Jun;36(3):1071-1079. doi: 10.1007/s12028-022-01493-4. Epub 2022 Apr 13. Neurocrit Care. 2022. PMID: 35419702 Review.
No language or publication date restrictions were applied. Ten studies were finally included, with a total of 1527 randomly assigned patients. Oral and intravenous nimodipine were both effective in preventing poor outcome, delayed cerebral ischemia, and delay …
No language or publication date restrictions were applied. Ten studies were finally included, with a total of 1527 randomly assigned …
Perioperative neuroprotection.
Klein KU, Engelhard K. Klein KU, et al. Best Pract Res Clin Anaesthesiol. 2010 Dec;24(4):535-49. doi: 10.1016/j.bpa.2010.10.008. Epub 2010 Nov 29. Best Pract Res Clin Anaesthesiol. 2010. PMID: 21619865 Review.
The endpoint of all cerebral injuries like stroke, global cerebral ischemia during cardiac arrest, cardiac, vascular, or brain surgery or head trauma is the inadequate supply of the brain with oxygen and glucose, which triggers a characteristic pathophysiologic casc …
The endpoint of all cerebral injuries like stroke, global cerebral ischemia during cardiac arrest, cardiac, vascular, or brain …
Neuroprotective therapy.
Hickenbottom SL, Grotta J. Hickenbottom SL, et al. Semin Neurol. 1998;18(4):485-92. doi: 10.1055/s-2008-1040901. Semin Neurol. 1998. PMID: 9932619 Review.
The phenomenon of the "ischemic cascade" has been described, and each step along this cascade provides a target for therapeutic intervention. In animal models of global and focal cerebral ischemia, numerous preclinical studies have demonstrated various agents to be …
The phenomenon of the "ischemic cascade" has been described, and each step along this cascade provides a target for therapeutic intervention …
Extracranial-intracranial bypass surgery for stroke prevention in hemodynamic cerebral ischemia: the Carotid Occlusion Surgery Study randomized trial.
Powers WJ, Clarke WR, Grubb RL Jr, Videen TO, Adams HP Jr, Derdeyn CP; COSS Investigators. Powers WJ, et al. JAMA. 2011 Nov 9;306(18):1983-92. doi: 10.1001/jama.2011.1610. JAMA. 2011. PMID: 22068990 Free PMC article. Clinical Trial.
CONTEXT: Patients with symptomatic atherosclerotic internal carotid artery occlusion (AICAO) and hemodynamic cerebral ischemia are at high risk for subsequent stroke when treated medically. OBJECTIVE: To test the hypothesis that extracranial-intracranial (EC-IC) byp …
CONTEXT: Patients with symptomatic atherosclerotic internal carotid artery occlusion (AICAO) and hemodynamic cerebral ischemia …
Prophylactic Therapies for Morbidity and Mortality After Aneurysmal Subarachnoid Hemorrhage: A Systematic Review and Network Meta-Analysis of Randomized Trials.
Dayyani M, Sadeghirad B, Grotta JC, Zabihyan S, Ahmadvand S, Wang Y, Guyatt GH, Amin-Hanjani S. Dayyani M, et al. Stroke. 2022 Jun;53(6):1993-2005. doi: 10.1161/STROKEAHA.121.035699. Epub 2022 Mar 31. Stroke. 2022. PMID: 35354302
Compared to placebo, clazosentan (10 mg/kg; OR, 0.39 [95% CI, 0.22-0.68]; high certainty; ARR, -16.65%), nicardipine (OR, 0.48 [95% CI, 0.24-0.94]; moderate certainty; ARR, -13.70%), fasudil (OR, 0.55 [95% CI, 0.31-0.98]; moderate certainty; ARR, -11.54%), and magnesium (OR, 0.66 …
Compared to placebo, clazosentan (10 mg/kg; OR, 0.39 [95% CI, 0.22-0.68]; high certainty; ARR, -16.65%), nicardipine (OR, 0.48 [95% CI, 0.24 …
Sphingosine 1-Phosphate Receptors in Cerebral Ischemia.
Gaire BP, Choi JW. Gaire BP, et al. Neuromolecular Med. 2021 Mar;23(1):211-223. doi: 10.1007/s12017-020-08614-2. Epub 2020 Sep 10. Neuromolecular Med. 2021. PMID: 32914259 Review.
In particular, some of the S1P receptors, including S1P(1), S1P(2), and S1P(3), have been identified as pathogenic players in cerebral ischemia. Other than these receptors, S1P itself and S1P-producing enzymes have been shown to play certain roles in cerebral …
In particular, some of the S1P receptors, including S1P(1), S1P(2), and S1P(3), have been identified as pathogenic players in cerebral …
Phenytoin revisited.
Finkel MJ. Finkel MJ. Clin Ther. 1984;6(5):577-91. Clin Ther. 1984. PMID: 6383610 Review.
Clinical trials of phenytoin in most of these disorders are ongoing or are contemplated. ...Based on phenytoin's pharmacologic effects in animals, controlled trials of the drug appear to be warranted in cerebral ischemia and stroke, spinal cord injury, angina …
Clinical trials of phenytoin in most of these disorders are ongoing or are contemplated. ...Based on phenytoin's pharmacologic effect …
3,205 results