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Quoted phrase not found in phrase index: "Cerebral amyloid angiopathy, APP-related"
Page 1
Presymptomatic Dutch-Type Hereditary Cerebral Amyloid Angiopathy-Related Blood Metabolite Alterations.
Chatterjee P, Fagan AM, Xiong C, McKay M, Bhatnagar A, Wu Y, Singh AK, Taddei K, Martins I, Gardener SL, Molloy MP, Multhaup G, Masters CL, Schofield PR, Benzinger TLS, Morris JC, Bateman RJ, Greenberg SM, Wermer MJH, van Buchem MA, Sohrabi HR, Martins RN; Dominantly Inherited Alzheimer Network. Chatterjee P, et al. J Alzheimers Dis. 2021;79(2):895-903. doi: 10.3233/JAD-201267. J Alzheimers Dis. 2021. PMID: 33361604 Free PMC article.

RESULTS: 275 metabolites were measured in the plasma, 22 of which were observed to be significantly lower in theD-CAAMCs compared to D-CAA NCs, following adjustment for potential confounding factors age, sex, and APOE epsilon4 (p < 00.05). ...Plasma spermidine was also

…
RESULTS: 275 metabolites were measured in the plasma, 22 of which were observed to be significantly lower in theD-CAAMCs compared to …
Cerebral Amyloid Angiopathy With Vascular Iron Accumulation and Calcification.
Bulk M, Moursel LG, van der Graaf LM, van Veluw SJ, Greenberg SM, van Duinen SG, van Buchem MA, van Rooden S, van der Weerd L. Bulk M, et al. Stroke. 2018 Sep;49(9):2081-2087. doi: 10.1161/STROKEAHA.118.021872. Stroke. 2018. PMID: 30354978
This study aimed at defining the underlying pathology associated with the in vivo observed striped pattern. Methods- Formalin-fixed postmortem brain material including the occipital lobe of 4 hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D) cases and 6 …
This study aimed at defining the underlying pathology associated with the in vivo observed striped pattern. Methods- Formalin-fixed p …
Temporal Ordering of Biomarkers in Dutch-Type Hereditary Cerebral Amyloid Angiopathy.
Koemans EA, Rasing I, Voigt S, van Harten TW, van der Zwet RGJ, Kaushik K, Schipper MR, van der Weerd N, van Zwet EW, van Etten ES, van Osch MJP, Kuiperij B, Verbeek MM, Terwindt GM, Greenberg SM, van Walderveen MAA, Wermer MJH. Koemans EA, et al. Stroke. 2024 Apr;55(4):954-962. doi: 10.1161/STROKEAHA.123.044688. Epub 2024 Mar 6. Stroke. 2024. PMID: 38445479 Free PMC article.
Markers of nonhemorrhagic injury (>20 enlarged perivascular spaces in the centrum semiovale and white matter hyperintensities Fazekas score, 2, present in 83% [n=54]) and markers of impaired cerebrovascular reactivity (abnormal BOLD amplitude, time to peak and time to b …
Markers of nonhemorrhagic injury (>20 enlarged perivascular spaces in the centrum semiovale and white matter hyperintensities Fazekas …
Osteopontin and phospho-SMAD2/3 are associated with calcification of vessels in D-CAA, an hereditary cerebral amyloid angiopathy.
Grand Moursel L, van der Graaf LM, Bulk M, van Roon-Mom WMC, van der Weerd L. Grand Moursel L, et al. Brain Pathol. 2019 Nov;29(6):793-802. doi: 10.1111/bpa.12721. Epub 2019 Apr 4. Brain Pathol. 2019. PMID: 30868685 Free PMC article.
In severe forms of cerebral amyloid angiopathy (CAA) pathology, vascular calcification has been observed in the cerebral cortex, both in vivo on MRI and CT, and post-mortem using histopathology. ...This was independently of the vessel size, including capillaries in the mos …
In severe forms of cerebral amyloid angiopathy (CAA) pathology, vascular calcification has been observed in the cerebral cortex, both …
Innovative Magnetic Resonance Imaging Markers of Hereditary Cerebral Amyloid Angiopathy at 7 Tesla.
Koemans EA, van Etten ES, van Opstal AM, Labadie G, Terwindt GM, Wermer MJH, Webb AG, Gurol EM, Greenberg SM, van Buchem MA, van der Grond J, van Rooden S. Koemans EA, et al. Stroke. 2018 Jun;49(6):1518-1520. doi: 10.1161/STROKEAHA.117.020302. Epub 2018 Apr 25. Stroke. 2018. PMID: 29695466 Free PMC article.
BACKGROUND AND PURPOSE: The aim of the present study is to explore whether using 7 Tesla magnetic resonance imaging, additional brain changes can be observed in hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D) patients as compared with the established m …
BACKGROUND AND PURPOSE: The aim of the present study is to explore whether using 7 Tesla magnetic resonance imaging, additional brain change …
Tissue transglutaminase colocalizes with extracellular matrix proteins in cerebral amyloid angiopathy.
de Jager M, van der Wildt B, Schul E, Bol JG, van Duinen SG, Drukarch B, Wilhelmus MM. de Jager M, et al. Neurobiol Aging. 2013 Apr;34(4):1159-69. doi: 10.1016/j.neurobiolaging.2012.10.005. Epub 2012 Oct 31. Neurobiol Aging. 2013. PMID: 23122413 Free article.
Here, we investigated the distribution pattern, cellular source, and activity of tTG in CAA in control, AD, and HCHWA-D cases. We observed increased tTG immunoreactivity and colocalization with Abeta in the vessel wall in early stage CAA, whereas in later CAA stages, tTG a …
Here, we investigated the distribution pattern, cellular source, and activity of tTG in CAA in control, AD, and HCHWA-D cases. We observe …
TGFβ pathway deregulation and abnormal phospho-SMAD2/3 staining in hereditary cerebral hemorrhage with amyloidosis-Dutch type.
Grand Moursel L, Munting LP, van der Graaf LM, van Duinen SG, Goumans MTH, Ueberham U, Natté R, van Buchem MA, van Roon-Mom WMC, van der Weerd L. Grand Moursel L, et al. Brain Pathol. 2018 Jul;28(4):495-506. doi: 10.1111/bpa.12533. Epub 2017 Jun 12. Brain Pathol. 2018. PMID: 28557134 Free PMC article.
We graded pSMAD2/3 accumulation in angiopathic vessels and found a positive correlation with the CAA load independent of the brain area. We also observed pSMAD2/3 granules in a halo surrounding occipital vessels, which was specific for HCHWA-D. ...
We graded pSMAD2/3 accumulation in angiopathic vessels and found a positive correlation with the CAA load independent of the brain area. We …