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126 results

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Page 1
Circulating biomarkers in familial cerebral cavernous malformation.
Lazzaroni F, Meessen JMTA, Sun Y, Lanfranconi S, Scola E, D'Alessandris QG, Tassi L, Carriero MR, Castori M, Marino S, Blanda A, Nicolis EB, Novelli D, Calabrese R, Agnelli NM, Bottazzi B, Leone R, Mazzola S, Besana S, Catozzi C, Nezi L, Lampugnani MG, Malinverno M, Grdseloff N, Rödel CJ, Rezai Jahromi B, Bolli N, Passamonti F, Magnusson PU, Abdelilah-Seyfried S, Dejana E, Latini R. Lazzaroni F, et al. EBioMedicine. 2024 Jan;99:104914. doi: 10.1016/j.ebiom.2023.104914. Epub 2023 Dec 18. EBioMedicine. 2024. PMID: 38113759 Free PMC article.
BACKGROUND: Cerebral Cavernous Malformation (CCM) is a rare cerebrovascular disease, characterized by the presence of multiple vascular malformations that may result in intracerebral hemorrhages (ICHs), seizure(s), or focal neurological deficits (FND). ...GDF …
BACKGROUND: Cerebral Cavernous Malformation (CCM) is a rare cerebrovascular disease, characterized by the presence of m …
Clinical characteristics and long-term outcome of cerebral cavernous malformations-related epilepsy.
Shih YC, Chou CC, Peng SJ, Yu HY, Hsu SPC, Lin CF, Lee CC, Yang HC, Chen YC, Kwan SY, Chen C, Wang SJ, Lin CJ, Lirng JF, Shih YH, Yen DJ, Liu YT. Shih YC, et al. Epilepsia. 2022 Aug;63(8):2056-2067. doi: 10.1111/epi.17309. Epub 2022 Jun 14. Epilepsia. 2022. PMID: 35593439

The most common lesion site in the DRE group was the mesiotemporal lobe (50%). Multiple CCMs were more frequently observed in the CRE (29.2%) than the NE (11.5%) group (p < .05). In patients with CRE, multiple lesions were associated with a higher rebleeding rate (odds

The most common lesion site in the DRE group was the mesiotemporal lobe (50%). Multiple CCMs were more frequently observed in the CRE …
Multiple cerebral cavernous malformations: Clinical course of confirmed, assumed and non-familial disease.
Santos AN, Rauschenbach L, Saban D, Chen B, Darkwah Oppong M, Herten A, Gull HH, Rieß C, Deuschl C, Schmidt B, Jabbarli R, Wrede KH, Zhu Y, Frank B, Sure U, Dammann P. Santos AN, et al. Eur J Neurol. 2022 May;29(5):1427-1434. doi: 10.1111/ene.15253. Epub 2022 Feb 3. Eur J Neurol. 2022. PMID: 35060255
BACKGROUND AND PURPOSE: Analyze and compare the natural course of confirmed familial cerebral cavernous malformation (FCCM), assumed FCCM and non-familial multiple cerebral cavernous malformation (CCM) disease over a 5-year period. ...Uni …
BACKGROUND AND PURPOSE: Analyze and compare the natural course of confirmed familial cerebral cavernous malformation (F …
Genetics of cerebral cavernous malformations: current status and future prospects.
Choquet H, Pawlikowska L, Lawton MT, Kim H. Choquet H, et al. J Neurosurg Sci. 2015 Sep;59(3):211-20. Epub 2015 Apr 22. J Neurosurg Sci. 2015. PMID: 25900426 Free PMC article. Review.
Understanding the genetic architecture of CCM is essential for an earlier diagnosis of the disease, predictive testing of at-risk patients, and design of targeted medical therapies of which there are currently none available....
Understanding the genetic architecture of CCM is essential for an earlier diagnosis of the disease, predictive testing of at-risk pat …
Cerebral cavernous malformation: Management and outcome during pregnancy and puerperium. A systematic review of literature.
Merlino L, Del Prete F, Titi L, Piccioni MG. Merlino L, et al. J Gynecol Obstet Hum Reprod. 2021 Jan;50(1):101927. doi: 10.1016/j.jogoh.2020.101927. Epub 2020 Oct 6. J Gynecol Obstet Hum Reprod. 2021. PMID: 33035718
The puerperium is a critical time for the woman with cavernomas for the possibility of bleeding and clinical observation must be continued. CONCLUSION: The patients with a diagnosis of a CCMs can have a pregnancy without any particular risk to themselves and the fetus but …
The puerperium is a critical time for the woman with cavernomas for the possibility of bleeding and clinical observation must be cont …
Cerebral cavernous malformation remnants after surgery: a single-center series with long-term bleeding risk analysis.
Fontanella MM, Agosti E, Zanin L, di Bergamo LT, Doglietto F. Fontanella MM, et al. Neurosurg Rev. 2021 Oct;44(5):2639-2645. doi: 10.1007/s10143-020-01436-7. Epub 2020 Nov 19. Neurosurg Rev. 2021. PMID: 33211201 Free PMC article. Review.
The aim of this work is to investigate the long-term bleeding risk of cerebral cavernous malformation (CCM) remnants. A review of clinical, radiological, operative, and post-operative data of a cerebral cavernous malformation (CCMs) prosp …
The aim of this work is to investigate the long-term bleeding risk of cerebral cavernous malformation (CCM) remnants. A …
Intracranial Hemorrhage Rate and Lesion Burden in Patients With Familial Cerebral Cavernous Malformation.
Weinsheimer S, Nelson J, Abla AA, Ko NU, Tsang C, Okoye O, Zabramski JM, Akers A, Zafar A, Mabray MC, Hart BL, Morrison L, McCulloch CE, Kim H; Brain Vascular Malformation Consortium Cerebral Cavernous Malformation Investigator Group *. Weinsheimer S, et al. J Am Heart Assoc. 2023 Feb 7;12(3):e027572. doi: 10.1161/JAHA.122.027572. Epub 2023 Jan 25. J Am Heart Assoc. 2023. PMID: 36695309 Free PMC article.
In addition, total CCM lesion burden is significantly associated with increased risk of subsequent symptomatic ICH; hence lesion burden may be an important predictor of patient outcome and aid patient risk stratification....
In addition, total CCM lesion burden is significantly associated with increased risk of subsequent symptomatic ICH; hence lesion burden may …
Bleeding risk evaluation in cerebral cavernous malformation, the role of medications, and hemorrhagic factors: a case-control study.
Scerrati A, Mantovani G, Travaglini F, Bradaschia L, De Bonis P, Farneti M, Cavallo MA, Dones F, Flacco ME, Auricchio AM, Benato A, Albanese A, Sturiale CL. Scerrati A, et al. Neurosurg Focus. 2023 Oct;55(4):E15. doi: 10.3171/2023.7.FOCUS23355. Neurosurg Focus. 2023. PMID: 37778034
METHOD: This was a multicenter retrospective observational study. The authors collected imaging, clinical status, and therapy data on patients with bleeding and nonbleeding CCMs. ...Antithrombotic agents and propranolol seem to have a protective role against the bleeding e …
METHOD: This was a multicenter retrospective observational study. The authors collected imaging, clinical status, and therapy data on …
Clinical characteristics of familial and sporadic pediatric cerebral cavernous malformations and outcomes.
Jaman E, Abdallah HM, Zhang X, Greene S. Jaman E, et al. J Neurosurg Pediatr. 2023 Jul 21;32(4):506-513. doi: 10.3171/2023.5.PEDS22397. Print 2023 Oct 1. J Neurosurg Pediatr. 2023. PMID: 37503918
OBJECTIVE: Cerebral cavernous malformation (CCM) is a subtype of the vascular malformations found within the cerebral cortex. ...Familial etiology of the disease and larger average lesion volume were independent, significant predictors of disease progr …
OBJECTIVE: Cerebral cavernous malformation (CCM) is a subtype of the vascular malformations found within the cerebral c …
Editome landscape of CCM-derived endothelial cells.
Scimone C, Alibrandi S, Donato L, Alafaci C, Germanò A, Vinci SL, D'Angelo R, Sidoti A. Scimone C, et al. RNA Biol. 2022 Jan;19(1):852-865. doi: 10.1080/15476286.2022.2091306. RNA Biol. 2022. PMID: 35771000 Free PMC article.
RNA editing dysregulation can affect RNA molecule half-life, coding/noncoding RNA interaction, alternative splicing, and circular RNA biogenesis. Impaired RNA editing has been observed in several pathological conditions, including cancer and Alzheimer's disease. No data ha …
RNA editing dysregulation can affect RNA molecule half-life, coding/noncoding RNA interaction, alternative splicing, and circular RNA biogen …
126 results