Etiopathogenic role of ERK5 signaling in sarcoma: prognostic and therapeutic implications.
Sánchez-Fdez A, Matilla-Almazán S, Del Carmen S, Abad M, Arconada-Luque E, Jiménez-Suárez J, Chinchilla-Tábora LM, Ruíz-Hidalgo MJ, Sánchez-Prieto R, Pandiella A, Esparís-Ogando A.
Sánchez-Fdez A, et al.
Exp Mol Med. 2023 Jun;55(6):1247-1257. doi: 10.1038/s12276-023-01008-x. Epub 2023 Jun 19.
Exp Mol Med. 2023.
PMID: 37332046
Free PMC article.
By developing a mouse model engineered to express a constitutively active form of MEK5, we demonstrate that the exclusive activation of the MEK5/ERK5 pathway can promote sarcomagenesis. Histopathological analyses identified these tumors as undifferentiated pleomorphic …
By developing a mouse model engineered to express a constitutively active form of MEK5, we demonstrate that the exclusive activation of the …