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Chlormethine Gel for the Treatment of Skin Lesions in All Stages of Mycosis Fungoides Cutaneous T-Cell Lymphoma: A Narrative Review and International Experience.
Geskin LJ, Bagot M, Hodak E, Kim EJ. Geskin LJ, et al. Dermatol Ther (Heidelb). 2021 Aug;11(4):1085-1106. doi: 10.1007/s13555-021-00539-3. Epub 2021 May 21. Dermatol Ther (Heidelb). 2021. PMID: 34021485 Free PMC article. Review.
While chlormethine is an efficacious therapy, its usage may be complicated by the development of cutaneous reactions at the sites of application. Herein, we discuss the supportive guidelines for MF and the suitability of chlormethine as a therapeutic option in patie …
While chlormethine is an efficacious therapy, its usage may be complicated by the development of cutaneous reactions at the sites of …
Chlormethine gel in combination with other therapies for treatment of mycosis fungoides: a review with patient cases.
Ardigò M, Nikbakht N, Teoli M, Gleason L, Crisan L, Querfeld C. Ardigò M, et al. Front Med (Lausanne). 2024 Jan 11;10:1308491. doi: 10.3389/fmed.2023.1308491. eCollection 2023. Front Med (Lausanne). 2024. PMID: 38274457 Free PMC article. Review.
However, there are no treatment guidelines on the use of combination regimens with chlormethine gel. To provide real-world evidence and guidance on the use of chlormethine gel combination regimens, several cases of patients treated with chlormethine gel combi …
However, there are no treatment guidelines on the use of combination regimens with chlormethine gel. To provide real-world evidence a …
The optimal use of chlormethine gel for mycosis fungoides: An expert consensus from Germany, Austria and Switzerland (DACH region).
Assaf C, Booken N, Dippel E, Guenova E, Jonak C, Klemke CD, Nicolay JP, Schlaak M, Wobser M, Trautinger F. Assaf C, et al. J Dtsch Dermatol Ges. 2022 May;20(5):579-586. doi: 10.1111/ddg.14688. Epub 2022 Apr 15. J Dtsch Dermatol Ges. 2022. PMID: 35429108 Review.
BACKGROUND: In Europe chlormethine gel is licensed for the management of patients with mycosis fungoides of all stages. ...CONCLUSIONS: The use of chlormethine gel in the management of mycosis fungoides is often limited by a concomitant contact dermatitis. ...
BACKGROUND: In Europe chlormethine gel is licensed for the management of patients with mycosis fungoides of all stages. ...CONCLUSION …
Chlormethine Gel is Efficient and Safe in Mycosis Fungoides Skin Lesions.
Koumourtzis M, Lampadaki K, Dalamaga M, Papadavid E. Koumourtzis M, et al. Acta Derm Venereol. 2022 Jun 9;102:adv00730. doi: 10.2340/actadv.v102.1095. Acta Derm Venereol. 2022. PMID: 35199177 Free PMC article.
Chlormethine is a bifunctional cytotoxic alkylating agent that binds to DNA, resulting in cell death (apoptosis). Chlormethine (also known as mechlorethamine) gel (CL gel) was approved in the European Union in 2017 and was first used in 2019. ...
Chlormethine is a bifunctional cytotoxic alkylating agent that binds to DNA, resulting in cell death (apoptosis). Chlormethine …
Mechanism of action of chlormethine gel in mycosis fungoides.
Guenova E, Ortiz-Romero PL, Poligone B, Querfeld C. Guenova E, et al. J Eur Acad Dermatol Venereol. 2023 Sep;37(9):1739-1748. doi: 10.1111/jdv.19237. Epub 2023 Jul 1. J Eur Acad Dermatol Venereol. 2023. PMID: 37262305 Review.
International consensus guidelines recommend skin-directed therapies (SDTs) as first-line treatment for early-stage disease, and SDTs combined with systemic therapy for advanced stages. Chlormethine (CL), also known as mechlorethamine, chlorethazine, mustine, HN2, caryolys …
International consensus guidelines recommend skin-directed therapies (SDTs) as first-line treatment for early-stage disease, and SDTs combin …
Chlormethine Gel for Patients with Mycosis Fungoides Cutaneous T Cell Lymphoma: A Review of Efficacy and Safety in Clinical Trial and Real-World Settings.
Wehkamp U, Ardigò M, Papadavid E, Querfeld C, Nikbakht N. Wehkamp U, et al. Adv Ther. 2022 Sep;39(9):3979-4002. doi: 10.1007/s12325-022-02219-w. Epub 2022 Jul 19. Adv Ther. 2022. PMID: 35852707 Free PMC article. Review.
Mycosis fungoides (MF) is a rare disease and is the most common form of cutaneous T cell lymphoma. Topical chlormethine (CL) gel is the first cytotoxic chemotherapy gel that was specifically developed for treatment of MF. ...
Mycosis fungoides (MF) is a rare disease and is the most common form of cutaneous T cell lymphoma. Topical chlormethine (CL) gel is t …
Topical chlormethine gel in the treatment of mycosis fungoides: A single-center real-life experience and systematic review of the literature.
Laghi A, Franceschini C, Mandel VD, Teoli M, Musicco F, Sansone M, La Malfa AM, Ardigò M. Laghi A, et al. Dermatol Ther. 2022 Sep;35(9):e15683. doi: 10.1111/dth.15683. Epub 2022 Jul 27. Dermatol Ther. 2022. PMID: 35778940 Review.
Gel formulation of chlormethine (CG) has gained a preeminent role among therapies available for mycosis fungoides (MF). ...MEDLINE (PubMed), Scopus, and Web of Science were each queried from their date of inception with the following terms: "mechlorethamine gel", "chlor …
Gel formulation of chlormethine (CG) has gained a preeminent role among therapies available for mycosis fungoides (MF). ...MEDLINE (P …
Chlormethine Gel (Ledaga): CADTH Reimbursement Recommendation: Indication: The topical treatment of stage IA and IB mycosis fungoides-type cutaneous T-cell lymphoma in adult patients who have received prior skin-directed therapy.
[No authors listed] [No authors listed] Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2021 Dec. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2021 Dec. PMID: 37616425 Free Books & Documents. Review.
Although evidence from a clinical trial found that Ledaga was not inferior to chlormethine ointment, chlormethine ointment is not used in Canada. There was no evidence to show whether Ledaga works better than or similar to treatments for MF-CTCL that are currently u …
Although evidence from a clinical trial found that Ledaga was not inferior to chlormethine ointment, chlormethine ointment is …
Chlormethine gel is effective for the treatment of skin lesions in patients with early- and late-stage mycosis fungoides in clinical practice.
Papadavid E, Koumourtzis M, Nikolaou V, Lampadaki K, Marinos L, Patsatsi A, Georgiou E, Dalamaga M, Stratigos A. Papadavid E, et al. J Eur Acad Dermatol Venereol. 2022 Oct;36(10):1751-1757. doi: 10.1111/jdv.18183. Epub 2022 May 12. J Eur Acad Dermatol Venereol. 2022. PMID: 35470483 Clinical Trial.
BACKGROUND: Chlormethine gel is a skin-directed therapy used for patients with mycosis fungoides (MF) that showed a favourable risk/benefit profile in a randomized clinical trial. Currently, data on chlormethine gel use in real-world settings are limited. OBJECTIVES …
BACKGROUND: Chlormethine gel is a skin-directed therapy used for patients with mycosis fungoides (MF) that showed a favourable risk/b …
88 results