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Quoted phrase not found in phrase index: "Chronic Lymphocytic Leukemia with Immunoglobulin Heavy Chain Variable-Region Gene Somatic Hypermutation"
Page 1
What do somatic hypermutation and class switch recombination teach us about chronic lymphocytic leukaemia pathogenesis?
Oppezzo P, Dighiero G. Oppezzo P, et al. Curr Top Microbiol Immunol. 2005;294:71-89. doi: 10.1007/3-540-29933-5_5. Curr Top Microbiol Immunol. 2005. PMID: 16323428 Review.
Interestingly, the presence or absence of somatic hypermutation (SHM) process is associated with the use of particular VH genes. ...In CLL with mutated Ig genes, the proliferating B cell may have transited through germinal centres, the ph …
Interestingly, the presence or absence of somatic hypermutation (SHM) process is associated with the use of particular VH g …
Genome-wide mutational signatures revealed distinct developmental paths for human B cell lymphomas.
Ye X, Ren W, Liu D, Li X, Li W, Wang X, Meng FL, Yeap LS, Hou Y, Zhu S, Casellas R, Zhang H, Wu K, Pan-Hammarström Q. Ye X, et al. J Exp Med. 2021 Feb 1;218(2):e20200573. doi: 10.1084/jem.20200573. J Exp Med. 2021. PMID: 33136155 Free PMC article.
Dysregulation of these processes has been linked to B cell lymphomagenesis. Here we performed an in-depth analysis of diffuse large B cell lymphoma (DLBCL) and follicular lymphoma (FL) genomes. ...Similar patterns were also observed in chroni …
Dysregulation of these processes has been linked to B cell lymphomagenesis. Here we performed an in-depth analysis of diffuse …
Pathology consultation on evaluating prognosis in incidental monoclonal lymphocytosis and chronic lymphocytic leukemia.
Siddon AJ, Rinder HM; Education Committee of the Academy of Clinical Laboratory Physicians and Scientists. Siddon AJ, et al. Am J Clin Pathol. 2013 Jun;139(6):708-12. doi: 10.1309/AJCPLIR4GZWX3XKA. Am J Clin Pathol. 2013. PMID: 23690112 Review.
Chronic lymphocytic leukemia (CLL) is a monoclonal B-cell lymphoproliferative disorder generally characterized by an indolent clinical course. ...Laboratory studies include surface CD38 and intracellular ZAP-70 expression by flow cytometry, seru …
Chronic lymphocytic leukemia (CLL) is a monoclonal B-cell lymphoproliferative disorder generally characte …
Immunoglobulin gene rearrangements and mutational status in argentinian patients with chronic lymphocytic leukemia.
Stanganelli C, Travella A, Bezares R, Slavutsky I. Stanganelli C, et al. Clin Lymphoma Myeloma Leuk. 2013 Aug;13(4):447-457.e2. doi: 10.1016/j.clml.2013.02.019. Epub 2013 May 9. Clin Lymphoma Myeloma Leuk. 2013. PMID: 23665144
BACKGROUND: Chronic lymphocytic leukemia (CLL) is a clinically heterogeneous disease. The mutational status of the immunoglobulin heavy chain variable (IGHV) region represents one of the best prognostic markers and defines 2 disease subgr …
BACKGROUND: Chronic lymphocytic leukemia (CLL) is a clinically heterogeneous disease. The mutational status of the i …
Chronic Lymphocytic Leukemia with Mutated IGHV4-34 Receptors: Shared and Distinct Immunogenetic Features and Clinical Outcomes.
Xochelli A, Baliakas P, Kavakiotis I, Agathangelidis A, Sutton LA, Minga E, Ntoufa S, Tausch E, Yan XJ, Shanafelt T, Plevova K, Boudjogra M, Rossi D, Davis Z, Navarro A, Sandberg Y, Vojdeman FJ, Scarfo L, Stavroyianni N, Sudarikov A, Veronese S, Tzenou T, Karan-Djurasevic T, Catherwood M, Kienle D, Chatzouli M, Facco M, Bahlo J, Pott C, Pedersen LB, Mansouri L, Smedby KE, Chu CC, Giudicelli V, Lefranc MP, Panagiotidis P, Juliusson G, Anagnostopoulos A, Vlahavas I, Antic D, Trentin L, Montillo M, Niemann C, Döhner H, Langerak AW, Pospisilova S, Hallek M, Campo E, Chiorazzi N, Maglaveras N, Oscier D, Gaidano G, Jelinek DF, Stilgenbauer S, Chouvarda I, Darzentas N, Belessi C, Davi F, Hadzidimitriou A, Rosenquist R, Ghia P, Stamatopoulos K. Xochelli A, et al. Clin Cancer Res. 2017 Sep 1;23(17):5292-5301. doi: 10.1158/1078-0432.CCR-16-3100. Epub 2017 May 23. Clin Cancer Res. 2017. PMID: 28536306
Purpose: We sought to investigate whether B cell receptor immunoglobulin (BcR IG) stereotypy is associated with particular clinicobiological features among chronic lymphocytic leukemia (CLL) patients expressing mutated BcR IG (M-CLL) enco …
Purpose: We sought to investigate whether B cell receptor immunoglobulin (BcR IG) stereotypy is associated with particu …
Comprehensive characterization of immunoglobulin gene rearrangements in patients with chronic lymphocytic leukaemia.
René C, Prat N, Thuizat A, Broctawik M, Avinens O, Eliaou JF. René C, et al. J Cell Mol Med. 2014 Jun;18(6):979-90. doi: 10.1111/jcmm.12215. Epub 2014 Apr 11. J Cell Mol Med. 2014. PMID: 24725733 Free PMC article.
Previous studies have suggested a geographical pattern of immunoglobulin rearrangement in chronic lymphocytic leukaemia (CLL), which could be as a result of a genetic background or an environmental antigen. However, the characteristics of Ig rearrangem …
Previous studies have suggested a geographical pattern of immunoglobulin rearrangement in chronic lymphocytic leukae …
Prognostic usage of V(H) gene mutation status and its surrogate markers and the role of antigen selection in chronic lymphocytic leukemia.
Tobin G, Rosenquist R. Tobin G, et al. Med Oncol. 2005;22(3):217-28. doi: 10.1385/MO:22:3:217. Med Oncol. 2005. PMID: 16110132 Review.
B-cell chronic lymphocytic leukemia (CLL) is a clinically heterogeneous disease with many patients surviving for decades with minimal or no treatment, whereas others succumb rapidly to their disease despite therapy. ...Intriguingly, the V(H)3-21 …
B-cell chronic lymphocytic leukemia (CLL) is a clinically heterogeneous disease with many patients surviv …
Different spectra of recurrent gene mutations in subsets of chronic lymphocytic leukemia harboring stereotyped B-cell receptors.
Sutton LA, Young E, Baliakas P, Hadzidimitriou A, Moysiadis T, Plevova K, Rossi D, Kminkova J, Stalika E, Pedersen LB, Malcikova J, Agathangelidis A, Davis Z, Mansouri L, Scarfò L, Boudjoghra M, Navarro A, Muggen AF, Yan XJ, Nguyen-Khac F, Larrayoz M, Panagiotidis P, Chiorazzi N, Niemann CU, Belessi C, Campo E, Strefford JC, Langerak AW, Oscier D, Gaidano G, Pospisilova S, Davi F, Ghia P, Stamatopoulos K, Rosenquist R; ERIC, the European Research Initiative on CLL. Sutton LA, et al. Haematologica. 2016 Aug;101(8):959-67. doi: 10.3324/haematol.2016.141812. Epub 2016 May 19. Haematologica. 2016. PMID: 27198719 Free PMC article.
We report on markedly different frequencies of genetic lesions within subsets of chronic lymphocytic leukemia patients carrying mutated or unmutated stereotyped B-cell receptor immunoglobulins in the largest cohort (n=565) studied for this purpo …
We report on markedly different frequencies of genetic lesions within subsets of chronic lymphocytic leukemia patients …
IGHV gene usage and mutational status in follicular lymphoma: Correlations with prognosis and patient age.
Berget E, Molven A, Løkeland T, Helgeland L, Vintermyr OK. Berget E, et al. Leuk Res. 2015 Jul;39(7):702-8. doi: 10.1016/j.leukres.2015.03.003. Epub 2015 Mar 19. Leuk Res. 2015. PMID: 25900812 Free article.
Follicular lymphoma (FL) is a heterogeneous disease with some patients developing progressively or transformed disease early, whereas others follow an indolent clinical course. We evaluated the prognostic value of immunoglobulin heavy chain variable (IGHV) …
Follicular lymphoma (FL) is a heterogeneous disease with some patients developing progressively or transformed disease early, whereas others …
Evidence of canonical somatic hypermutation in hairy cell leukemia.
Arons E, Roth L, Sapolsky J, Suntum T, Stetler-Stevenson M, Kreitman RJ. Arons E, et al. Blood. 2011 May 5;117(18):4844-51. doi: 10.1182/blood-2010-11-316737. Epub 2011 Mar 2. Blood. 2011. PMID: 21368287 Free PMC article.
To compare hairy cell leukemia (HCL) with chronic lymphocytic leukemia (CLL) and normal B cells with respect to their B-cell receptors, somatic hypermutation (SHM) features in HCL were examined in a series of 130 immunogl …
To compare hairy cell leukemia (HCL) with chronic lymphocytic leukemia (CLL) and normal B cells with respect to …
30 results