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Page 1
Chronic neutrophilic leukemia preceded by myelodysplastic syndromes.
Baba Y, Nakamaki T, Sakai H, Fukuchi K, Kabasawa N, Hattori N, Harada H. Baba Y, et al. Int J Hematol. 2023 Nov;118(5):636-641. doi: 10.1007/s12185-023-03636-5. Epub 2023 Jul 13. Int J Hematol. 2023. PMID: 37439996
Chronic neutrophilic leukemia (CNL) is primarily diagnosed by excluding myelodysplastic syndromes (MDS). ...At the time of MDS diagnosis, U2AF1 Q157P and SETBP1 D868N were dominant and additional mutation of ASXL1 1934_insG was observed. CSF3R T618I an …
Chronic neutrophilic leukemia (CNL) is primarily diagnosed by excluding myelodysplastic syndromes (MDS). ...At the time …
Genomic landscape of neutrophilic leukemias of ambiguous diagnosis.
Zhang H, Wilmot B, Bottomly D, Dao KT, Stevens E, Eide CA, Khanna V, Rofelty A, Savage S, Reister Schultz A, Long N, White L, Carlos A, Henson R, Lin C, Searles R, Collins RH, DeAngelo DJ, Deininger MW, Dunn T, Hein T, Luskin MR, Medeiros BC, Oh ST, Pollyea DA, Steensma DP, Stone RM, Druker BJ, McWeeney SK, Maxson JE, Gotlib JR, Tyner JW. Zhang H, et al. Blood. 2019 Sep 12;134(11):867-879. doi: 10.1182/blood.2019000611. Epub 2019 Jul 31. Blood. 2019. PMID: 31366621 Free PMC article.
Chronic neutrophilic leukemia (CNL), atypical chronic myeloid leukemia (aCML), and myelodysplastic/myeloproliferative neoplasms, unclassifiable (MDS/MPN-U) are a group of rare and heterogeneous myeloid disorders. ...We, therefore, performed whole-exome and RN …
Chronic neutrophilic leukemia (CNL), atypical chronic myeloid leukemia (aCML), and myelodysplastic/myeloproliferative n …
Efficacy of Ruxolitinib in Patients With Chronic Neutrophilic Leukemia and Atypical Chronic Myeloid Leukemia.
Dao KT, Gotlib J, Deininger MMN, Oh ST, Cortes JE, Collins RH Jr, Winton EF, Parker DR, Lee H, Reister A, Schultz, Savage S, Stevens, Brockett C, Subbiah N, Press RD, Raess PW, Cascio M, Dunlap J, Chen Y, Degnin C, Maxson JE, Tognon CE, Macey T, Druker BJ, Tyner JW. Dao KT, et al. J Clin Oncol. 2020 Apr 1;38(10):1006-1018. doi: 10.1200/JCO.19.00895. Epub 2019 Dec 27. J Clin Oncol. 2020. PMID: 31880950 Free PMC article. Clinical Trial.
PURPOSE: Colony-stimulating factor-3 receptor (CSF3R)-T618I is a recurrent activating mutation in chronic neutrophilic leukemia (CNL) and to a lesser extent in atypical chronic myeloid leukemia (aCML) resulting in constitutive JAK-STAT signaling. ...The most …
PURPOSE: Colony-stimulating factor-3 receptor (CSF3R)-T618I is a recurrent activating mutation in chronic neutrophilic leuk …
Chronic neutrophilic leukaemia and plasma cell-related neutrophilic leukaemoid reactions.
Bain BJ, Ahmad S. Bain BJ, et al. Br J Haematol. 2015 Nov;171(3):400-10. doi: 10.1111/bjh.13600. Epub 2015 Jul 27. Br J Haematol. 2015. PMID: 26218186 Free article. Review.
We have analysed all accessible reported cases to clarify the likely diagnosis and to ascertain whether toxic granulation, Dohle bodies and an increased neutrophil alkaline phosphatase score were useful in making a distinction between chronic neutrophilic leukaemia and a n …
We have analysed all accessible reported cases to clarify the likely diagnosis and to ascertain whether toxic granulation, Dohle bodies and …
Chronic neutrophilic leukemia: 2018 update on diagnosis, molecular genetics and management.
Elliott MA, Tefferi A. Elliott MA, et al. Am J Hematol. 2018 Aug;93(4):578-587. doi: 10.1002/ajh.24983. Am J Hematol. 2018. PMID: 29512199 Free article. Review.

DISEASE OVERVIEW AND DIAGNOSIS: Chronic neutrophilic leukemia (CNL) is a potentially aggressive myeloproliferative neoplasm, for which current WHO diagnostic criteria include leukocytosis of 25 x 10(9) /L of which 80% are neutrophils, with < 10% circulatin

…
DISEASE OVERVIEW AND DIAGNOSIS: Chronic neutrophilic leukemia (CNL) is a potentially aggressive myeloproliferative neop …
Chronic neutrophilic leukaemia.
Gan GG, Pasagna JF, Eow GI, Nadarajan VS. Gan GG, et al. Singapore Med J. 2007 Mar;48(3):e74-6. Singapore Med J. 2007. PMID: 17342275 Free article.
He had splenomegaly, a raised vitamin B12 level, serum uric acid and neutrophil alkaline phosphatase score. Cytogenetic study of the marrow was normal and peripheral blood for BCR-ABL gene transcript was not detectable. ...
He had splenomegaly, a raised vitamin B12 level, serum uric acid and neutrophil alkaline phosphatase score. Cytogenetic study of the …
ASXL1 mutations are frequent and prognostically detrimental in CSF3R-mutated chronic neutrophilic leukemia.
Elliott MA, Pardanani A, Hanson CA, Lasho TL, Finke CM, Belachew AA, Tefferi A. Elliott MA, et al. Am J Hematol. 2015 Jul;90(7):653-6. doi: 10.1002/ajh.24031. Am J Hematol. 2015. PMID: 25850813 Free article.
Colony stimulating factor 3 receptor gene (CSF3R) mutations have recently been associated with chronic neutrophilic leukemia (CNL). Fourteen patients with CSF3R-mutated CNL (median age 67 years; 57% males) were screened for additional mutations; 8 (57%) and 5 …
Colony stimulating factor 3 receptor gene (CSF3R) mutations have recently been associated with chronic neutrophilic leukemi …
Neutrophil function and cytokine-specific signaling in chronic neutrophilic leukemia.
Uemura Y, Taguchi T, Kubota T, Saito T, Bandobashi K, Yokoyama A. Uemura Y, et al. Int J Lab Hematol. 2009 Feb;31(1):36-47. doi: 10.1111/j.1751-553X.2007.01000.x. Epub 2008 Jan 30. Int J Lab Hematol. 2009. PMID: 18241214
We diagnosed an 86-year-old woman with chronic neutrophilic leukemia (CNL) because she showed sustained leukocytosis dominated by mature neutrophils, hepatosplenomegaly, high neutrophilic alkaline phosphatase score, absence of the Ph chromosome, low se …
We diagnosed an 86-year-old woman with chronic neutrophilic leukemia (CNL) because she showed sustained leukocytosis do …
Coexistence of chronic neutrophilic leukemia with multiple myeloma.
Dinçol G, Nalçaci M, Doğan O, Aktan M, Küçükkaya R, Ağan M, Dinçol K. Dinçol G, et al. Leuk Lymphoma. 2002 Mar;43(3):649-51. doi: 10.1080/10428190290012218. Leuk Lymphoma. 2002. PMID: 12002774 Review.
A case report of simultaneous presentation of chronic neutrophilic leukemia and multiple myeloma (IgG kappa) in a 71-year-old male is described. ...The patient died of severe bronchopneumonia after the transformation of chronic neutrophilic l …
A case report of simultaneous presentation of chronic neutrophilic leukemia and multiple myeloma (IgG kappa) in a 71-ye …
Chronic neutrophilic leukemia--report of a case and review of the literature.
Wang JS, Ho CH, Lin CK. Wang JS, et al. Zhonghua Yi Xue Za Zhi (Taipei). 1990 Aug;46(2):109-12. Zhonghua Yi Xue Za Zhi (Taipei). 1990. PMID: 2177362 Review.
A male patient, aged 78, was found with chronic neutrophilic leukemia (CNL). The patient showed sustained mature neutrophilic leukocytosis, splenomegaly, a high leukocyte alkaline phosphatase score, elevated serum vitamin B12 and uric acid, myeloid hyp …
A male patient, aged 78, was found with chronic neutrophilic leukemia (CNL). The patient showed sustained mature neutro …
43 results