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Clobazam.
[No authors listed] [No authors listed] 2017 Jan 25. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. 2017 Jan 25. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. PMID: 31644172 Free Books & Documents. Review.
Clobazam is a benzodiazepine that is used as an anticonvulsant in the therapy of severe childhood epilepsy. Therapy with clobazam has not been associated with serum aminotransferase elevations, and clinically apparent liver injury from clobazam has yet to be …
Clobazam is a benzodiazepine that is used as an anticonvulsant in the therapy of severe childhood epilepsy. Therapy with clobazam …
Clobazam Therapy and CYP2C19 Genotype.
Dean L. Dean L. 2019 Sep 23. In: Pratt VM, Scott SA, Pirmohamed M, Esquivel B, Kattman BL, Malheiro AJ, editors. Medical Genetics Summaries [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2012–. 2019 Sep 23. In: Pratt VM, Scott SA, Pirmohamed M, Esquivel B, Kattman BL, Malheiro AJ, editors. Medical Genetics Summaries [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2012–. PMID: 31550100 Free Books & Documents. Review.
Clobazam (brand names Onfi, Sympazan) is approved by the FDA to treat seizures associated with Lennox-Gastaut syndrome (LGS) in patients aged 2 years and older (1). ...Clobazam is a 1,5-benzodiazepine that acts as a positive allosteric modulator of GABA(A) receptors …
Clobazam (brand names Onfi, Sympazan) is approved by the FDA to treat seizures associated with Lennox-Gastaut syndrome (LGS) in patie …
Clobazam.
Humayun MJ, Samanta D, Carson RP. Humayun MJ, et al. 2023 Dec 3. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. 2023 Dec 3. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 31082087 Free Books & Documents.
Clobazam was synthesized in the 1960s with the primary goal of providing greater efficacy with fewer benzodiazepine-related side effects. ...This activity reviews indications, mechanism of action, administration, contraindications, monitoring, and toxicity associated with …
Clobazam was synthesized in the 1960s with the primary goal of providing greater efficacy with fewer benzodiazepine-related side effe …
Clobazam add-on therapy for drug-resistant epilepsy.
Bresnahan R, Martin-McGill KJ, Williamson J, Michael BD, Marson AG. Bresnahan R, et al. Cochrane Database Syst Rev. 2019 Oct 22;10(10):CD004154. doi: 10.1002/14651858.CD004154.pub5. Cochrane Database Syst Rev. 2019. PMID: 31638272 Free PMC article. Review.
This review is an updated version of the original Cochrane Review, first published in 2008, and examines the most current literature regarding clobazam as an add-on for drug-resistant epilepsy. OBJECTIVES: To assess the efficacy, effectiveness and tolerability of clobaz …
This review is an updated version of the original Cochrane Review, first published in 2008, and examines the most current literature regardi …
Clobazam monotherapy for focal or generalized seizures.
Arya R, Giridharan N, Anand V, Garg SK. Arya R, et al. Cochrane Database Syst Rev. 2018 Jul 11;7(7):CD009258. doi: 10.1002/14651858.CD009258.pub3. Cochrane Database Syst Rev. 2018. PMID: 29995989 Free PMC article. Review.
There was low-quality evidence that clobazam led to better retention compared with phenytoin (RR 1.43, 95% CI 1.08 to 1.90). ...AUTHORS' CONCLUSIONS: We found no advantage for clobazam over carbamazepine for retention at 12 months in drug-naive children and a slight …
There was low-quality evidence that clobazam led to better retention compared with phenytoin (RR 1.43, 95% CI 1.08 to 1.90). ...AUTHO …
Clobazam.
Ng YT, Collins SD. Ng YT, et al. Neurotherapeutics. 2007 Jan;4(1):138-44. doi: 10.1016/j.nurt.2006.11.002. Neurotherapeutics. 2007. PMID: 17199029 Free PMC article. Review.
This review will explore the use of clobazam in the treatment of epilepsy, particularly with regard to its potential benefit in LGS. ...A phase 2 study will be completed in late 2006 to investigate the safety and efficacy of clobazam as adjunctive therapy in 68 pedi …
This review will explore the use of clobazam in the treatment of epilepsy, particularly with regard to its potential benefit in LGS. …
Clobazam and Its Use in Epilepsy.
Pernea M, Sutcliffe AG. Pernea M, et al. Pediatr Rep. 2016 Jun 15;8(2):6516. doi: 10.4081/pr.2016.6516. eCollection 2016 Jun 15. Pediatr Rep. 2016. PMID: 27433306 Free PMC article. Review.
Clobazam (CLB) is an older anti-epileptic drug, with a slightly different chemical structure from that of the classic benzodiazepines currently used in the treatment of epilepsy, which confers less sedative properties in terms of negative adverse effects. ...
Clobazam (CLB) is an older anti-epileptic drug, with a slightly different chemical structure from that of the classic benzodiazepines …
Corticosteroids versus clobazam in epileptic encephalopathy with ESES: a European multicentre randomised controlled clinical trial (RESCUE ESES*).
van den Munckhof B, Arzimanoglou A, Perucca E, van Teeseling HC, Leijten FSS, Braun KPJ, Jansen FE; RESCUE ESES study group. van den Munckhof B, et al. Trials. 2020 Nov 23;21(1):957. doi: 10.1186/s13063-020-04874-2. Trials. 2020. PMID: 33228736 Free PMC article. Clinical Trial.
Based on mostly small and retrospective studies, corticosteroids and clobazam are regarded by many clinicians as the most effective pharmacological treatments. This European multicentre randomised controlled trial is designed to compare the effects of corticosteroids and …
Based on mostly small and retrospective studies, corticosteroids and clobazam are regarded by many clinicians as the most effective p …
Clobazam monotherapy for partial-onset or generalized-onset seizures.
Arya R, Anand V, Garg SK, Michael BD. Arya R, et al. Cochrane Database Syst Rev. 2014 Oct 4;(10):CD009258. doi: 10.1002/14651858.CD009258.pub2. Cochrane Database Syst Rev. 2014. PMID: 25280512 Updated. Review.
There was low quality evidence that clobazam led to better retention compared with phenytoin (RR 1.43, 95% CI 1.08 to 1.90). ...AUTHORS' CONCLUSIONS: We found no advantage for clobazam over carbamazepine for retention at 12 months in drug-naive children and a slight …
There was low quality evidence that clobazam led to better retention compared with phenytoin (RR 1.43, 95% CI 1.08 to 1.90). ...AUTHO …
Clobazam for treatment of epilepsy.
Giarratano M, Standley K, Benbadis SR. Giarratano M, et al. Expert Opin Pharmacother. 2012 Feb;13(2):227-33. doi: 10.1517/14656566.2012.647686. Epub 2012 Jan 13. Expert Opin Pharmacother. 2012. PMID: 22242724 Review.
With this paper, readers will gain a better understanding of the limits of Lennox-Gastaut syndrome and how it evolves with age and what clobazam can contribute to its treatment. EXPERT OPINION: Clobazam offers a new treatment option for patients with refractory epil …
With this paper, readers will gain a better understanding of the limits of Lennox-Gastaut syndrome and how it evolves with age and what c …
1,254 results