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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1970 1
1971 3
1972 2
1973 9
1974 24
1975 49
1976 70
1977 62
1978 54
1979 50
1980 52
1981 30
1982 35
1983 50
1984 54
1985 39
1986 59
1987 48
1988 65
1989 95
1990 127
1991 145
1992 218
1993 265
1994 363
1995 378
1996 419
1997 390
1998 409
1999 460
2000 421
2001 424
2002 406
2003 436
2004 459
2005 485
2006 480
2007 506
2008 488
2009 428
2010 446
2011 489
2012 470
2013 493
2014 480
2015 464
2016 543
2017 526
2018 511
2019 560
2020 587
2021 682
2022 637
2023 598
2024 266

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14,991 results

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Page 1
Clozapine-induced agranulocytosis.
Mijovic A, MacCabe JH. Mijovic A, et al. Ann Hematol. 2020 Nov;99(11):2477-2482. doi: 10.1007/s00277-020-04215-y. Epub 2020 Aug 20. Ann Hematol. 2020. PMID: 32815018 Free PMC article. Review.
Wider use of clozapine, one of the most effective antipshychotic drugs, is precluded by its propensity to cause agranulocytosis. ...With a significant proportion of clozapine recipients in Western hemisphere being Black, we comment on the importance of recognizing b …
Wider use of clozapine, one of the most effective antipshychotic drugs, is precluded by its propensity to cause agranulocytosis. ...W …
Pharmacokinetics and pharmacodynamics of clozapine.
Jann MW, Grimsley SR, Gray EC, Chang WH. Jann MW, et al. Clin Pharmacokinet. 1993 Feb;24(2):161-76. doi: 10.2165/00003088-199324020-00005. Clin Pharmacokinet. 1993. PMID: 8453823 Review.
Clozapine is metabolised via the hepatic microsomal enzyme system into 2 principle metabolites: demethyl-clozapine and clozapine N-oxide. Urine samples have reported the ratio of clozapine:demethyl:N-oxide to be 1:1:2. The clozapine N-oxide bind …
Clozapine is metabolised via the hepatic microsomal enzyme system into 2 principle metabolites: demethyl-clozapine and cloz …
A Rational Use of Clozapine Based on Adverse Drug Reactions, Pharmacokinetics, and Clinical Pharmacopsychology.
de Leon J, Ruan CJ, Schoretsanitis G, De Las Cuevas C. de Leon J, et al. Psychother Psychosom. 2020;89(4):200-214. doi: 10.1159/000507638. Epub 2020 Apr 14. Psychother Psychosom. 2020. PMID: 32289791 Free PMC article. Review.
In the absence of data on COVID-19 in clozapine patients, clozapine possibly impairs immunological mechanisms and may increase pneumonia risk in infected patients. Psychiatrists should call their clozapine patients and families and explain to them that if the …
In the absence of data on COVID-19 in clozapine patients, clozapine possibly impairs immunological mechanisms and may increase …
Clozapine use in geriatric patients- Challenges.
Mukku SSR, Sivakumar PT, Varghese M. Mukku SSR, et al. Asian J Psychiatr. 2018 Mar;33:63-67. doi: 10.1016/j.ajp.2018.03.008. Epub 2018 Mar 3. Asian J Psychiatr. 2018. PMID: 29529421 Review.
Clozapine is the first second generation antipsychotic with different receptor profile of action. ...There is paucity of literature with respect to clozapine use in late life. In this narrative review, we discuss clozapine use in elderly and challenges associ …
Clozapine is the first second generation antipsychotic with different receptor profile of action. ...There is paucity of literature w …
Clinical Experience With Intramuscular Clozapine.
Munzar B, Nemets B. Munzar B, et al. Cureus. 2021 Sep 25;13(9):e18267. doi: 10.7759/cureus.18267. eCollection 2021 Sep. Cureus. 2021. PMID: 34589377 Free PMC article. Review.
The use of IM clozapine has been reported in older studies on clozapine's adverse effects. ...IM clozapine has been used at approximately of the dose of oral clozapine due to pharmacokinetic considerations. ...
The use of IM clozapine has been reported in older studies on clozapine's adverse effects. ...IM clozapine has been use …
Clozapine rechallenge and initiation despite neutropenia- a practical, step-by-step guide.
Silva E, Higgins M, Hammer B, Stephenson P. Silva E, et al. BMC Psychiatry. 2020 Jun 5;20(1):279. doi: 10.1186/s12888-020-02592-2. BMC Psychiatry. 2020. PMID: 32503471 Free PMC article. Review.
Clozapine remains the only drug treatment likely to benefit patients with treatment resistant schizophrenia. Its use is complicated by an increased risk of neutropenia and so there are stringent monitoring requirements and restrictions in those with previous neutropenia fr …
Clozapine remains the only drug treatment likely to benefit patients with treatment resistant schizophrenia. Its use is complicated b …
Clozapine-induced seizure.
Borah AJ, Kalita A, Dutta SK. Borah AJ, et al. Indian J Pharmacol. 2019 Nov-Dec;51(6):410-412. doi: 10.4103/ijp.IJP_403_18. Epub 2020 Jan 16. Indian J Pharmacol. 2019. PMID: 32029964 Free PMC article.
There are very few reports which suggest an association between antipsychotic clozapine low dose and seizure. We report a case in which intial titration of low dose clozapine developed seizure. ...Later, clozapine was maintained on 250 mg/day, with no recurre …
There are very few reports which suggest an association between antipsychotic clozapine low dose and seizure. We report a case in whi …
Clozapine, a fast-off-D2 antipsychotic.
Seeman P. Seeman P. ACS Chem Neurosci. 2014 Jan 15;5(1):24-9. doi: 10.1021/cn400189s. Epub 2013 Nov 18. ACS Chem Neurosci. 2014. PMID: 24219174 Free PMC article. Review.
The chemical structure of clozapine facilitates a relatively rapid dissociation from D2 receptors. ...Clozapine's transient occupation of D2 receptors permits patients to move easily and comfortably....
The chemical structure of clozapine facilitates a relatively rapid dissociation from D2 receptors. ...Clozapine's transient oc …
Clozapine.
Launer M. Launer M. Br J Hosp Med. 1993 Jan 6-19;49(1):56-8. Br J Hosp Med. 1993. PMID: 8431727 Review.
Clozapine is an atypical agent for intractable schizophrenia which was introduced into the UK at the beginning of 1990. ...
Clozapine is an atypical agent for intractable schizophrenia which was introduced into the UK at the beginning of 1990. ...
Clozapine.
[No authors listed] [No authors listed] Lancet. 1989 Dec 16;2(8677):1430-2. Lancet. 1989. PMID: 2574365 Review. No abstract available.
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