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Mexiletine in spinal and bulbar muscular atrophy: a randomized controlled trial.
Yamada S, Hashizume A, Hijikata Y, Inagaki T, Ito D, Kishimoto Y, Kinoshita F, Hirakawa A, Shimizu S, Nakamura T, Katsuno M. Yamada S, et al. Ann Clin Transl Neurol. 2022 Nov;9(11):1702-1714. doi: 10.1002/acn3.51667. Epub 2022 Oct 8. Ann Clin Transl Neurol. 2022. PMID: 36208052 Free PMC article. Clinical Trial.
There were no serious adverse events throughout the study period. INTERPRETATION: Cold paresis is common and associated with prolongation of distal latency in SBMA. The results of the phase II clinical trial revealed that mexiletine showed short-term s …
There were no serious adverse events throughout the study period. INTERPRETATION: Cold paresis is common and associated with p …
Study protocol for the MEXiletine hydrochloride administration trial: a placebo-controlled, randomised, double-blind, multicentre, crossover study of its efficacy and safety in spinal and bulbar muscular atrophy (MEXPRESS).
Yamada S, Hashizume A, Hijikata Y, Inagaki T, Ito D, Kinoshita F, Nakatochi M, Kobayashi Y, Hirakawa A, Nakamura T, Katsuno M. Yamada S, et al. BMJ Open. 2018 Sep 11;8(9):e023041. doi: 10.1136/bmjopen-2018-023041. BMJ Open. 2018. PMID: 30206090 Free PMC article.
Although mexiletine hydrochloride administration has been shown to be effective for the treatment of several muscular diseases, its effectiveness in SBMA has not been validated to date. The trial will test it as a symptomatic drug for cold paresis. This study …
Although mexiletine hydrochloride administration has been shown to be effective for the treatment of several muscular diseases, its effectiv …
Is cold paresis related to axonal depolarization?
Franssen H, Gebbink TA, Wokke JH, van den Berg LH, van Schelven LJ. Franssen H, et al. J Peripher Nerv Syst. 2010 Sep;15(3):227-37. doi: 10.1111/j.1529-8027.2010.00275.x. J Peripher Nerv Syst. 2010. PMID: 21040145
Cold paresis may occur in multifocal motor neuropathy and lower motor neuron disease. ...
Cold paresis may occur in multifocal motor neuropathy and lower motor neuron disease. ...