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98 results

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Quoted phrase not found in phrase index: "Collagen Fibrosis of the Bone Marrow"
Page 1
Primary myelofibrosis: 2023 update on diagnosis, risk-stratification, and management.
Tefferi A. Tefferi A. Am J Hematol. 2023 May;98(5):801-821. doi: 10.1002/ajh.26857. Epub 2023 Feb 6. Am J Hematol. 2023. PMID: 36680511 Free article. Review.
DISEASE OVERVIEW: Primary myelofibrosis (PMF) is a myeloproliferative neoplasm (MPN) characterized by stem cell-derived clonal myeloproliferation that is often but not always accompanied by JAK2, CALR, or MPL mutations; additional features include bone marrow reticu …
DISEASE OVERVIEW: Primary myelofibrosis (PMF) is a myeloproliferative neoplasm (MPN) characterized by stem cell-derived clonal myeloprolifer …
Fra-2-expressing macrophages promote lung fibrosis in mice.
Ucero AC, Bakiri L, Roediger B, Suzuki M, Jimenez M, Mandal P, Braghetta P, Bonaldo P, Paz-Ares L, Fustero-Torre C, Ximenez-Embun P, Hernandez AI, Megias D, Wagner EF. Ucero AC, et al. J Clin Invest. 2019 May 28;129(8):3293-3309. doi: 10.1172/JCI125366. J Clin Invest. 2019. PMID: 31135379 Free PMC article.
The AP-1 transcription factor Fra-2 is upregulated in IPF lung sections and Fra-2 transgenic mice (Fra-2tg) exhibit spontaneous lung fibrosis. Here we show that Bleomycin-induced lung fibrosis is attenuated upon myeloid-inactivation of Fra-2 and aggravated in Fra-2t …
The AP-1 transcription factor Fra-2 is upregulated in IPF lung sections and Fra-2 transgenic mice (Fra-2tg) exhibit spontaneous lung fibr …
Pharmacotherapy of Myelofibrosis.
Tremblay D, Marcellino B, Mascarenhas J. Tremblay D, et al. Drugs. 2017 Sep;77(14):1549-1563. doi: 10.1007/s40265-017-0797-y. Drugs. 2017. PMID: 28791654 Review.
Myelofibrosis (MF) is a myeloproliferative neoplasm that is pathologically characterized by bone marrow myeloproliferation, reticulin and collagen fibrosis, and extramedullary hematopoiesis. ...Additionally, ruxolitinib does not appear to affect the ma …
Myelofibrosis (MF) is a myeloproliferative neoplasm that is pathologically characterized by bone marrow myeloproliferation, re …
Myeloid-specific deletion of chitinase-3-like 1 protein ameliorates murine diet-induced steatohepatitis progression.
Kim AD, Kui L, Kaufmann B, Kim SE, Leszczynska A, Feldstein AE. Kim AD, et al. J Mol Med (Berl). 2023 Jul;101(7):813-828. doi: 10.1007/s00109-023-02325-4. Epub 2023 May 11. J Mol Med (Berl). 2023. PMID: 37166517 Free PMC article.
Chitinase-3-like 1 protein (CHI3L1) is a secreted glycoprotein, strongly correlated with fibrosis severity in chronic liver diseases including non-alcoholic steatohepatitis (NASH). ...In vitro studies were performed stimulating bone marrow derived macrophages …
Chitinase-3-like 1 protein (CHI3L1) is a secreted glycoprotein, strongly correlated with fibrosis severity in chronic liver diseases …
A Phase Ib Trial of AVID200, a TGFbeta 1/3 Trap, in Patients with Myelofibrosis.
Mascarenhas J, Migliaccio AR, Kosiorek H, Bhave R, Palmer J, Kuykendall A, Mesa R, Rampal RK, Gerds AT, Yacoub A, Pettit K, Talpaz M, Komrokji R, Kremyanskaya M, Gonzalez A, Fabris F, Johnson K, Dougherty M, McGovern E, Arango Ossa J, Domenico D, Farnoud N, Weinberg RS, Kong A, Najfeld V, Vannucchi AM, Arciprete F, Zingariello M, Falchi M, Salama ME, Mead-Harvey C, Dueck A, Varricchio L, Hoffman R. Mascarenhas J, et al. Clin Cancer Res. 2023 Sep 15;29(18):3622-3632. doi: 10.1158/1078-0432.CCR-23-0276. Clin Cancer Res. 2023. PMID: 37439808 Free PMC article. Clinical Trial.
PURPOSE: Myelofibrosis (MF) is a clonal myeloproliferative neoplasm characterized by systemic symptoms, cytopenias, organomegaly, and bone marrow fibrosis. JAK2 inhibitors afford symptom and spleen burden reduction but do not alter the disease course and freq …
PURPOSE: Myelofibrosis (MF) is a clonal myeloproliferative neoplasm characterized by systemic symptoms, cytopenias, organomegaly, and bon …
Metabolism of N-nitrosodimethylamine, methylation of macromolecules, and development of hepatic fibrosis in rodent models.
George J, Tsuchishima M, Tsutsumi M. George J, et al. J Mol Med (Berl). 2020 Sep;98(9):1203-1213. doi: 10.1007/s00109-020-01950-7. Epub 2020 Jul 14. J Mol Med (Berl). 2020. PMID: 32666246 Review.
The hallmark of fibrosis and cirrhosis is inordinate synthesis and deposition of fibril forming collagens in the extracellular matrix of the liver leading to nodule formation and loss of normal architecture. Hepatic stellate cells play a crucial role in the pathogen …
The hallmark of fibrosis and cirrhosis is inordinate synthesis and deposition of fibril forming collagens in the extracellular …
Liver fibrosis and hepatic stellate cells: Etiology, pathological hallmarks and therapeutic targets.
Zhang CY, Yuan WG, He P, Lei JH, Wang CX. Zhang CY, et al. World J Gastroenterol. 2016 Dec 28;22(48):10512-10522. doi: 10.3748/wjg.v22.i48.10512. World J Gastroenterol. 2016. PMID: 28082803 Free PMC article. Review.
Importantly, hepatic stellate cells (HSCs) play a key role in the initiation, progression, and regression of liver fibrosis by secreting fibrogenic factors that encourage portal fibrocytes, fibroblasts, and bone marrow-derived myofibroblasts to produce col …
Importantly, hepatic stellate cells (HSCs) play a key role in the initiation, progression, and regression of liver fibrosis by secret …
Can we remove scar and fibrosis from adult human myocardium?
Vazir A, Fox K, Westaby J, Evans MJ, Westaby S. Vazir A, et al. Eur Heart J. 2019 Mar 21;40(12):960-966. doi: 10.1093/eurheartj/ehy503. Eur Heart J. 2019. PMID: 30203057 Free article. Review.
Both animal studies and clinical trials support the concept that, as in infancy, cellular processes can be triggered to remove collagen and regenerate injured myocardium. The molecular mechanisms likely involve anti-fibrotic cytokines growth factors and matrix-metal …
Both animal studies and clinical trials support the concept that, as in infancy, cellular processes can be triggered to remove col …
Impact of bone marrow pathology on the clinical management of Philadelphia chromosome-negative myeloproliferative neoplasms.
Pozdnyakova O, Hasserjian RP, Verstovsek S, Orazi A. Pozdnyakova O, et al. Clin Lymphoma Myeloma Leuk. 2015 May;15(5):253-61. doi: 10.1016/j.clml.2014.11.002. Epub 2014 Nov 18. Clin Lymphoma Myeloma Leuk. 2015. PMID: 25515354 Review.
Moreover, the evaluation of bone marrow pathology has become very important in the new era of disease-modifying agents. ...Follow-up for up to 5 years of patients who participated in a phase 1/2 study of ruxolitinib, revealed stabilization or reversal of bone …
Moreover, the evaluation of bone marrow pathology has become very important in the new era of disease-modifying agents. ...Fol …
Anti-fibrotic potential of erythropoietin signaling on bone marrow derived fibrotic cell.
Iwata Y, Sakai N, Nakajima Y, Oshima M, Nakagawa-Yoneda S, Ogura H, Sato K, Minami T, Kitajima S, Toyama T, Yamamura Y, Miyagawa T, Hara A, Shimizu M, Furuichi K, Wada T. Iwata Y, et al. BMC Nephrol. 2021 May 31;22(1):203. doi: 10.1186/s12882-021-02411-0. BMC Nephrol. 2021. PMID: 34059008 Free PMC article.
INTRODUCTION: The number of patients with end stage kidney disease (ESKD) are increasing world-side. While interstitial fibrosis (IF) is a common step for the progression to ESKD, therapeutic options for IF is still limited in clinical settings. We have reported tha …
INTRODUCTION: The number of patients with end stage kidney disease (ESKD) are increasing world-side. While interstitial fibrosis (IF) …
98 results