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Quoted phrase not found in phrase index: "Combined oxidative phosphorylation deficiency 22"
Page 1
BCL-2 Inhibition as Treatment for Chronic Lymphocytic Leukemia.
Perini GF, Feres CCP, Teixeira LLC, Hamerschlak N. Perini GF, et al. Curr Treat Options Oncol. 2021 Jun 10;22(8):66. doi: 10.1007/s11864-021-00862-z. Curr Treat Options Oncol. 2021. PMID: 34110507 Review.
At the end of the 1990s, with the advent of imatinib for chronic myeloid leukemia and rituximab for B cell lymphoproliferative diseases with CD20 expression, there was a great conceptual evolution in the treatment of onco-hematological diseases. ...Molecular and gen …
At the end of the 1990s, with the advent of imatinib for chronic myeloid leukemia and rituximab for B cell lymphoproliferative diseases …
Machine learning compensates fold-change method and highlights oxidative phosphorylation in the brain transcriptome of Alzheimer's disease.
Cheng J, Liu HP, Lin WY, Tsai FJ. Cheng J, et al. Sci Rep. 2021 Jul 1;11(1):13704. doi: 10.1038/s41598-021-93085-z. Sci Rep. 2021. PMID: 34211065 Free PMC article.
To harness the AD mechanism's knowledge from the expression profiles of postmortem prefrontal cortex samples of 310 AD and 157 controls, we used seven predictive operators or combinations of RapidMiner Studio operators to establish predictive models from the …
To harness the AD mechanism's knowledge from the expression profiles of postmortem prefrontal cortex samples of 310 AD and 157 controls, we …
Preliminary study of Bim on the early diagnosis and prognosis of the elderly uremia with gastrointestinal nutrition combined with dialysis.
Yang M, Bai YH, Wang JS, Jiang HY, Hu SL. Yang M, et al. Eur Rev Med Pharmacol Sci. 2018 Jul;22(14):4598-4603. doi: 10.26355/eurrev_201807_15517. Eur Rev Med Pharmacol Sci. 2018. PMID: 30058698 Free article.
Mitochondrial protein Bim plays an essential role in regulating inflammation, restraining oxidative stress, and maintaining the balance of the mitochondrial membrane potential and energy production. This study aims to investigate the effect of Bim on the earl …
Mitochondrial protein Bim plays an essential role in regulating inflammation, restraining oxidative stress, and maintaining th …
YKL-40 and the Cellular Metabolic Profile in Parkinson's Disease.
Gevezova M, Kazakova M, Trenova A, Sarafian V. Gevezova M, et al. Int J Mol Sci. 2023 Nov 14;24(22):16297. doi: 10.3390/ijms242216297. Int J Mol Sci. 2023. PMID: 38003487 Free PMC article.
Patients were diagnosed according to the MDS-PD, the UPDRS, and the Hoen-Yahr scales. Mitochondrial activity was measured by a metabolic analyzer on isolated PBMCs from PD patients. ...These observations suggest an interplay between YKL-40 and mitochondrial function …
Patients were diagnosed according to the MDS-PD, the UPDRS, and the Hoen-Yahr scales. Mitochondrial activity was measured by a metabo …
Exercise training improves mitochondrial respiration and is associated with an altered intramuscular phospholipid signature in women with obesity.
Mendham AE, Goedecke JH, Zeng Y, Larsen S, George C, Hauksson J, Fortuin-de Smidt MC, Chibalin AV, Olsson T, Chorell E. Mendham AE, et al. Diabetologia. 2021 Jul;64(7):1642-1659. doi: 10.1007/s00125-021-05430-6. Epub 2021 Mar 26. Diabetologia. 2021. PMID: 33770195 Free PMC article. Clinical Trial.
AIMS/HYPOTHESIS: We sought to determine putative relationships among improved mitochondrial respiration, insulin sensitivity and altered skeletal muscle lipids and metabolite signature in response to combined aerobic and resistance training in women with obesity. .. …
AIMS/HYPOTHESIS: We sought to determine putative relationships among improved mitochondrial respiration, insulin sensitivity and alte …
Drug-induced liver injury through mitochondrial dysfunction: mechanisms and detection during preclinical safety studies.
Labbe G, Pessayre D, Fromenty B. Labbe G, et al. Fundam Clin Pharmacol. 2008 Aug;22(4):335-53. doi: 10.1111/j.1472-8206.2008.00608.x. Fundam Clin Pharmacol. 2008. PMID: 18705745 Review.
Several in vitro and in vivo investigations can be performed to determine if newly developed drugs disturb mitochondrial fatty acid oxidation (FAO) and the oxidative phosphorylation (OXPHOS) process, deplete hepatic mitochondrial DNA (mtDNA), or trigge …
Several in vitro and in vivo investigations can be performed to determine if newly developed drugs disturb mitochondrial fatty acid o …
Is oxidative stress a therapeutic target in cardiovascular disease?
Münzel T, Gori T, Bruno RM, Taddei S. Münzel T, et al. Eur Heart J. 2010 Nov;31(22):2741-8. doi: 10.1093/eurheartj/ehq396. Epub 2010 Oct 25. Eur Heart J. 2010. PMID: 20974801 Review.
Superoxide produced by the nicotinamide dinucleotide phosphate (NADPH) oxidase, mitochondrial sources, or the xanthine oxidase may react with NO, thereby resulting in excessive formation of peroxynitrite, a reactive nitrogen species that has been demonstrated to accelerate …
Superoxide produced by the nicotinamide dinucleotide phosphate (NADPH) oxidase, mitochondrial sources, or the xanthine oxidase may re …
Olaparib Is a Mitochondrial Complex I Inhibitor That Kills Temozolomide-Resistant Human Glioblastoma Cells.
Zampieri LX, Sboarina M, Cacace A, Grasso D, Thabault L, Hamelin L, Vazeille T, Dumon E, Rossignol R, Frédérick R, Sonveaux E, Lefranc F, Sonveaux P. Zampieri LX, et al. Int J Mol Sci. 2021 Nov 3;22(21):11938. doi: 10.3390/ijms222111938. Int J Mol Sci. 2021. PMID: 34769368 Free PMC article.
Rather, fitter mitochondria in TMZ-resistant glioblastoma cells are a direct cause of chemoresistance that can be targeted by inhibiting oxidative phosphorylation and/or autophagy/mitophagy. Unexpectedly, we found that PARP inhibitor olaparib, but not talazoparib, i …
Rather, fitter mitochondria in TMZ-resistant glioblastoma cells are a direct cause of chemoresistance that can be targeted by inhibiting …
Most Influential Physicochemical and In Vitro Assay Descriptors for Hepatotoxicity and Nephrotoxicity Prediction.
Rana P, Kogut S, Wen X, Akhlaghi F, Aleo MD. Rana P, et al. Chem Res Toxicol. 2020 Jul 20;33(7):1780-1790. doi: 10.1021/acs.chemrestox.0c00040. Epub 2020 May 8. Chem Res Toxicol. 2020. PMID: 32338883
In silico physicochemical property calculations and in vitro assays have been utilized separately in the early stages of the drug discovery and development process to predict drug safety. In this study, we combined physicochemical properties and in vitro cytotoxicit …
In silico physicochemical property calculations and in vitro assays have been utilized separately in the early stages of the drug discovery …
Sec6/8 regulates Bcl-2 and Mcl-1, but not Bcl-xl, in malignant peripheral nerve sheath tumor cells.
Tanaka T, Kikuchi N, Goto K, Iino M. Tanaka T, et al. Apoptosis. 2016 May;21(5):594-608. doi: 10.1007/s10495-016-1230-9. Apoptosis. 2016. PMID: 26892009
Given the vital roles of the exocyst complex in cellular and developmental processes, the disruption of its function may be closely related to various diseases such as cancer, diabetes, and neuronal disorders. Malignant peripheral nerve sheath tumors (MPNSTs) have high mal …
Given the vital roles of the exocyst complex in cellular and developmental processes, the disruption of its function may be closely related …
31 results