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Quoted phrase not found in phrase index: "Complement component 4b deficiency"
Page 1
Complement factor I: Regulatory nexus, driver of immunopathology, and therapeutic.
Hallam TM, Sharp SJ, Andreadi A, Kavanagh D. Hallam TM, et al. Immunobiology. 2023 Sep;228(5):152410. doi: 10.1016/j.imbio.2023.152410. Epub 2023 Jun 5. Immunobiology. 2023. PMID: 37478687 Free article.
Complement factor I (FI) is the nexus for classical, lectin and alternative pathway complement regulation. FI is an 88 kDa plasma protein that circulates in an inactive configuration until it forms a trimolecular complex with its cofactor and substrate whereupon a s …
Complement factor I (FI) is the nexus for classical, lectin and alternative pathway complement regulation. FI is an 88 kDa pla …
CD46: expanding beyond complement regulation.
Riley-Vargas RC, Gill DB, Kemper C, Liszewski MK, Atkinson JP. Riley-Vargas RC, et al. Trends Immunol. 2004 Sep;25(9):496-503. doi: 10.1016/j.it.2004.07.004. Trends Immunol. 2004. PMID: 15324743 Review.
During the 1980s CD46 was discovered in a search for C3b binding proteins of human peripheral blood cells. Its role as an inactivator of C3b and C4b deposited on self-tissue is highlighted by the observation that partial deficiency of CD46 is a predisposing f …
During the 1980s CD46 was discovered in a search for C3b binding proteins of human peripheral blood cells. Its role as an inactivator of C3b …
7th International Immunoglobulin Conference: Mechanisms of action.
Basta M, Branch DR. Basta M, et al. Clin Exp Immunol. 2014 Dec;178 Suppl 1(Suppl 1):87-8. doi: 10.1111/cei.12523. Clin Exp Immunol. 2014. PMID: 25546774 Free PMC article.
However, the beneficial effect of IVIg encompasses multiple mechanisms of action. One of these is scavenging of activated complement fragments, such as C3a, C5a, C3b and C4b, by infused Ig molecules. This interaction prevents binding of complement fragments t …
However, the beneficial effect of IVIg encompasses multiple mechanisms of action. One of these is scavenging of activated complement …
The intricate role of complement component C4 in human systemic lupus erythematosus.
Yang Y, Chung EK, Zhou B, Lhotta K, Hebert LA, Birmingham DJ, Rovin BH, Yu CY. Yang Y, et al. Curr Dir Autoimmun. 2004;7:98-132. doi: 10.1159/000075689. Curr Dir Autoimmun. 2004. PMID: 14719377 Review.
Complete deficiencies of complement components C4A and C4B, albeit rare in human populations, are among the strongest genetic risk factors for SLE or lupus-like disease, across HLA haplotypes and racial backgrounds. ...On the other hand, Spanish, Mexican, Aus …
Complete deficiencies of complement components C4A and C4B, albeit rare in human populations, are among the strongest g …
Diagnosing protein S deficiency: analytical considerations.
Persson KE, Dahlbäck B, Hillarp A. Persson KE, et al. Clin Lab. 2003;49(3-4):103-10. Clin Lab. 2003. PMID: 12705691 Review.
In plasma, approximately 70% of circulating protein S is bound to the complement regulatory C4b-binding protein. Deficiency of protein S is an established risk factor for thrombosis, but diagnosing such a condition is not a trivial task. ...Development of new …
In plasma, approximately 70% of circulating protein S is bound to the complement regulatory C4b-binding protein. Deficiency …
Impact of Homozygous C4A Deficiency on Clinical Presentation of Systemic Lupus Erythematosus.
Ansari AA, Tipu HN, Ahmad D, Farhan M. Ansari AA, et al. J Coll Physicians Surg Pak. 2020 Aug;30(8):790-795. doi: 10.29271/jcpsp.2020.08.790. J Coll Physicians Surg Pak. 2020. PMID: 32893787
Approval from the Institutional Ethical Review Board was taken. C4A and C4B null alleles were determined in 66 SLE patients and 40 age- and gender-matched healthy controls by polymerase chain reaction (PCR) using sequence-specific primers (PCR-SSP). ...Knowledge of C4A nul …
Approval from the Institutional Ethical Review Board was taken. C4A and C4B null alleles were determined in 66 SLE patients and 40 ag …
CipA mediates complement resistance of Acinetobacter baumannii by formation of a factor I-dependent quadripartite assemblage.
Ries JI, Heß M, Nouri N, Wichelhaus TA, Göttig S, Falcone FH, Kraiczy P. Ries JI, et al. Front Immunol. 2022 Jul 26;13:942482. doi: 10.3389/fimmu.2022.942482. eCollection 2022. Front Immunol. 2022. PMID: 35958553 Free PMC article.
Previously, we identified CipA as a plasminogen-binding and complement-inhibitory protein. Here we show that CipA inhibits all three complement activation pathways and interacts with key complement components C3, C3b, C4b, C5, Factor B, Factor D, and i …
Previously, we identified CipA as a plasminogen-binding and complement-inhibitory protein. Here we show that CipA inhibits all three …
Clinical Isolates of Acinetobacter spp. Are Highly Serum Resistant Despite Efficient Recognition by the Complement System.
Magda M, Bettoni S, Laabei M, Fairley D, Russo TA, Riesbeck K, Blom AM. Magda M, et al. Front Immunol. 2022 Jan 31;13:814193. doi: 10.3389/fimmu.2022.814193. eCollection 2022. Front Immunol. 2022. PMID: 35173727 Free PMC article.
Interestingly, we could not detect any significant concentration of deposited C1q, despite observing C4b deposition that was abolished in C1q-deficient serum, indicating transient binding of C1q to bacteria. Moreover, several isolates were recognized by MBL, …
Interestingly, we could not detect any significant concentration of deposited C1q, despite observing C4b deposition that was a …
Increased frequency of complement C4B deficiency in rheumatoid arthritis.
Rigby WF, Wu YL, Zan M, Zhou B, Rosengren S, Carlson C, Hilton W, Yu CY. Rigby WF, et al. Arthritis Rheum. 2012 May;64(5):1338-44. doi: 10.1002/art.33472. Arthritis Rheum. 2012. PMID: 22076784 Free PMC article.
OBJECTIVE: To assess the copy number variation of complement C4A and C4B genes in patients with rheumatoid arthritis (RA). ...C4B deficiency was more frequent in seropositive RA patients than in seronegative RA patients (44% versus 31%). ...
OBJECTIVE: To assess the copy number variation of complement C4A and C4B genes in patients with rheumatoid arthritis (RA). ... …
The role of complement in the host's defense against Haemophilus influenzae.
Winkelstein JA, Moxon ER. Winkelstein JA, et al. J Infect Dis. 1992 Jun;165 Suppl 1:S62-5. doi: 10.1093/infdis/165-supplement_1-s62. J Infect Dis. 1992. PMID: 1588179 Review.
In vivo studies and observations in complement-deficient patients have established the biologic significance of complement in the host's defense against H. influenzae. ...More recently, a relatively common deficiency of one isotype of C4 (C4B …
In vivo studies and observations in complement-deficient patients have established the biologic significance of comp …
105 results