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Phenotypes of complement knockouts.
Holers VM. Holers VM. Immunopharmacology. 2000 Aug;49(1-2):125-31. doi: 10.1016/s0162-3109(00)80298-2. Immunopharmacology. 2000. PMID: 10904112 Review.
Although complete and partial complement deficiencies are well described in humans and several spontaneous animal models, many questions have remained regarding the exact role that these deficiency states play in the observed clinical manifestations. Likewise, many importa …
Although complete and partial complement deficiencies are well described in humans and several spontaneous animal models, many questions hav …
Genetic deficiencies of the complement system and association with disease--early components.
Kölble K, Reid KB. Kölble K, et al. Int Rev Immunol. 1993;10(1):17-36. doi: 10.3109/08830189309051169. Int Rev Immunol. 1993. PMID: 8340675 Review.
Genetic deficiency of one of the early components of the classical pathway of complement (C1q, C1r, C1s, C4 and C2) is often associated with clinical symptoms and immunochemical abnormalities common in idiopathic autoimmune diseases, such as lupus erythematosus, but also with an …
Genetic deficiency of one of the early components of the classical pathway of complement (C1q, C1r, C1s, C4 and C2) is often associated with …
A non-synonymous variant rs12614 of complement factor B associated with risk of chronic hepatitis B in a Korean population.
Seo JY, Shin JG, Youn BJ, Namgoong S, Cheong HS, Kim LH, Kim JO, Shin HD, Kim YJ. Seo JY, et al. BMC Med Genet. 2020 Dec 17;21(1):241. doi: 10.1186/s12881-020-01177-w. BMC Med Genet. 2020. PMID: 33334325 Free PMC article.
Additional linkage disequilibrium and conditional analysis confirmed that rs12614 had independent genetic effect on CHB susceptibility with previously identified CHB markers. The genetic risk scores (GRSs) were calculated and the CHB patients had higher GRSs than the popul …
Additional linkage disequilibrium and conditional analysis confirmed that rs12614 had independent genetic effect on CHB susceptibility with …
Complement deficiency ameliorates collagen-induced arthritis in mice.
Hietala MA, Jonsson IM, Tarkowski A, Kleinau S, Pekna M. Hietala MA, et al. J Immunol. 2002 Jul 1;169(1):454-9. doi: 10.4049/jimmunol.169.1.454. J Immunol. 2002. PMID: 12077276
A repeated bovine collagen type II exposure 3 wk after the initial immunization led to an increase in the Ab response in all mice and triggered arthritis also in the complement-deficient mice. Although the arthritic score of the C3(-/-) mice was low, the arthritis in FB(-/ …
A repeated bovine collagen type II exposure 3 wk after the initial immunization led to an increase in the Ab response in all mice and trigge …
Membrane protein Crry maintains homeostasis of the complement system.
Wu X, Spitzer D, Mao D, Peng SL, Molina H, Atkinson JP. Wu X, et al. J Immunol. 2008 Aug 15;181(4):2732-40. doi: 10.4049/jimmunol.181.4.2732. J Immunol. 2008. PMID: 18684964 Free PMC article.
The C3 and fB protein concentrations in Crry(-/-)C3(+/-) and Crry(-/-)fB(+/-) mice were substantially reduced for gene dosage secondary to enhanced AP turnover. Based on these observations, a breeding strategy featuring reduced maternal AP-activating capacity rescued the l …
The C3 and fB protein concentrations in Crry(-/-)C3(+/-) and Crry(-/-)fB(+/-) mice were substantially reduced for gene dosage secondary to e …
Hypocomplementemia in the absence of autoantibodies in women with recurrent pregnancy loss.
Micheloud D, Sarmiento E, Teijeiro R, Jensen J, Rodríguez Molina JJ, Fernández-Cruz E, Carbone J. Micheloud D, et al. Allergol Immunopathol (Madr). 2007 May-Jun;35(3):90-4. doi: 10.1157/13106775. Allergol Immunopathol (Madr). 2007. PMID: 17594871
In all, hypocomplementemia, in the absence of autoantibodies, was observed in 38 (18.9%) women with recurrent PL in a significantly higher frequency than controls (n = 2, p = 0.049). CONCLUSIONS: Hypocomplementemia, in the absence of autoantibodies was observed in a …
In all, hypocomplementemia, in the absence of autoantibodies, was observed in 38 (18.9%) women with recurrent PL in a significantly h …