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2012 1
2017 2
2021 1
2022 2
2024 0

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Deep learning identified pathological abnormalities predictive of graft loss in kidney transplant biopsies.
Yi Z, Salem F, Menon MC, Keung K, Xi C, Hultin S, Haroon Al Rasheed MR, Li L, Su F, Sun Z, Wei C, Huang W, Fredericks S, Lin Q, Banu K, Wong G, Rogers NM, Farouk S, Cravedi P, Shingde M, Smith RN, Rosales IA, O'Connell PJ, Colvin RB, Murphy B, Zhang W. Yi Z, et al. Kidney Int. 2022 Feb;101(2):288-298. doi: 10.1016/j.kint.2021.09.028. Epub 2021 Oct 30. Kidney Int. 2022. PMID: 34757124 Free PMC article.
The Interstitial and Tubular Abnormality Score (ITAS) in baseline samples was highly predictive of one-year graft loss, while a Composite Damage Score in 12-month post-transplant protocol biopsies predicted later graft loss. ITASs and Composite Damage …
The Interstitial and Tubular Abnormality Score (ITAS) in baseline samples was highly predictive of one-year graft loss, while …
Dietary fat composition shapes bile acid metabolism and severity of liver injury in a pig model of pediatric NAFLD.
Manjarín R, Dillard K, Coffin M, Hernandez GV, Smith VA, Noland-Lidell T, Gehani TR, Smart HJ, Wheeler K, Sprayberry KA, Edwards MS, Fanter RK, Glanz H, Immoos C, Santiago-Rodriguez TM, Blank JM, Burrin DG, Piccolo BD, Abo-Ismail M, La Frano MR, Maj M. Manjarín R, et al. Am J Physiol Endocrinol Metab. 2022 Sep 1;323(3):E187-E206. doi: 10.1152/ajpendo.00052.2022. Epub 2022 Jul 20. Am J Physiol Endocrinol Metab. 2022. PMID: 35858244 Free PMC article.
In addition, both COC and OLI reduced circulating fibroblast growth factor 19, increased hepatic necrosis, composite lesion score, and liver enzymes in serum, and upregulated genes involved in hepatocyte proliferation and DNA repair. ...
In addition, both COC and OLI reduced circulating fibroblast growth factor 19, increased hepatic necrosis, composite lesion …
A New Preclinical Paradigm for Testing Anti-Aging Therapeutics.
Ladiges W, Snyder JM, Wilkinson E, Imai DM, Snider T, Ge X, Ciol M, Pettan-Brewer C, Pillai SPS, Morton J, Quarles E, Rabinovitch P, Niedernhofer L, Liggitt D. Ladiges W, et al. J Gerontol A Biol Sci Med Sci. 2017 Jun 1;72(6):760-762. doi: 10.1093/gerona/glx019. J Gerontol A Biol Sci Med Sci. 2017. PMID: 28329081 Free PMC article.
A new paradigm, designated as the Geropathology Grading Platform (GGP), is based on a standardized set of guidelines developed to detect the presence or absence of low-impact histopathological lesions and to determine the level of severity of high-impact lesions in organs from ag …
A new paradigm, designated as the Geropathology Grading Platform (GGP), is based on a standardized set of guidelines developed to detect the …
Quantitative Assessment of Early [18F]Sodium Fluoride Positron Emission Tomography/Computed Tomography Response to Treatment in Men With Metastatic Prostate Cancer to Bone.
Harmon SA, Perk T, Lin C, Eickhoff J, Choyke PL, Dahut WL, Apolo AB, Humm JL, Larson SM, Morris MJ, Liu G, Jeraj R. Harmon SA, et al. J Clin Oncol. 2017 Aug 20;35(24):2829-2837. doi: 10.1200/JCO.2017.72.2348. Epub 2017 Jun 27. J Clin Oncol. 2017. PMID: 28654366 Free PMC article. Clinical Trial.
Global imaging metrics, including maximum standardized uptake value (SUV(max)) and total functional burden (SUV(total)), were extracted from composite lesion-level statistics for each patient and tracked throughout treatment. ...Total functional burden assessed afte …
Global imaging metrics, including maximum standardized uptake value (SUV(max)) and total functional burden (SUV(total)), were extracted from …
Preliminary clinical activity of a topical JAK1/2 inhibitor in the treatment of psoriasis.
Punwani N, Scherle P, Flores R, Shi J, Liang J, Yeleswaram S, Levy R, Williams W, Gottlieb A. Punwani N, et al. J Am Acad Dermatol. 2012 Oct;67(4):658-64. doi: 10.1016/j.jaad.2011.12.018. Epub 2012 Jan 24. J Am Acad Dermatol. 2012. PMID: 22281165 Clinical Trial.
RESULTS: Both the 1% and the 1.5% cream improved lesion thickness, erythema, and scaling and reduced lesion area compared with placebo. A composite lesion score decreased by greater than 50% with the efficacious doses of INCB018424 compared with 32% for vehic …
RESULTS: Both the 1% and the 1.5% cream improved lesion thickness, erythema, and scaling and reduced lesion area compared with placebo. A …