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58 results

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Page 1
Incidence and predictors of treatment-related conjugated hyperbilirubinemia during early treatment phases for children with acute lymphoblastic leukemia.
Hashmi SK, Navai SA, Chambers TM, Scheurer ME, Hicks MJ, Rau RE, Gramatges MM. Hashmi SK, et al. Pediatr Blood Cancer. 2020 Feb;67(2):e28063. doi: 10.1002/pbc.28063. Epub 2019 Nov 17. Pediatr Blood Cancer. 2020. PMID: 31736183 Free PMC article.
Conjugated hyperbilirubinemia (CHB) and liver transaminase elevation are known complications of acute lymphoblastic leukemia (ALL) therapy, but host risk factors are poorly understood. Among 373 children diagnosed with ALL between 2011 and 2016, clinically significa …
Conjugated hyperbilirubinemia (CHB) and liver transaminase elevation are known complications of acute lymphoblastic leukemia ( …
Acute liver failure due to DGUOK deficiency-is liver transplantation justified?
Jankowska I, Czubkowski P, Rokicki D, Lipiński P, Piekutowska-Abramczuk D, Ciara E, Płoski R, Kaliciński P, Szymczak M, Pawłowska J, Socha P. Jankowska I, et al. Clin Res Hepatol Gastroenterol. 2021 Jan;45(1):101408. doi: 10.1016/j.clinre.2020.02.018. Epub 2020 Apr 8. Clin Res Hepatol Gastroenterol. 2021. PMID: 32278775 Review.
In the current literature, there are only few reports regarding long-term observation of children with DGUOK deficiency. Liver transplantation (LTx) is controversial due to extrahepatic involvement and unpredictable outcome. ...RESULTS: In all children clinical symptoms de …
In the current literature, there are only few reports regarding long-term observation of children with DGUOK deficiency. Liver transp …
Biliary atresia: pathogenesis and treatment.
Bates MD, Bucuvalas JC, Alonso MH, Ryckman FC. Bates MD, et al. Semin Liver Dis. 1998;18(3):281-93. doi: 10.1055/s-2007-1007164. Semin Liver Dis. 1998. PMID: 9773428 Review.
Untreated, the resulting cholestasis leads to progressive conjugated hyperbilirubinemia, cirrhosis, and hepatic failure. Biliary atresia has an incidence of approximately one in 10,000 live births worldwide. ...Consequently, a prompt evaluation is indicated for any …
Untreated, the resulting cholestasis leads to progressive conjugated hyperbilirubinemia, cirrhosis, and hepatic failure. Bilia …
Conjugated Hyperbilirubinemia in Infants: Is There Still a Role for ERCP?
Stovicek J, Hlava S, Keil R, Drabek J, Lochmannova J, Koptová P, Wasserbauer M, Frybova B, Snajdauf J, Kotalova R, Rygl M. Stovicek J, et al. Can J Gastroenterol Hepatol. 2021 Jun 24;2021:9969825. doi: 10.1155/2021/9969825. eCollection 2021. Can J Gastroenterol Hepatol. 2021. PMID: 34258256 Free PMC article.
Our study has proved that ERCP is a safe and reliable method in this age group. Its high specificity and negative predictive value for extrahepatic biliary atresia can prevent unnecessary surgeries in patients with normal bile ducts or endoscopically treatable pathologies. …
Our study has proved that ERCP is a safe and reliable method in this age group. Its high specificity and negative predictive value fo …
Neonatal lupus: clinical features and management.
Lee LA. Lee LA. Paediatr Drugs. 2004;6(2):71-8. doi: 10.2165/00148581-200406020-00001. Paediatr Drugs. 2004. PMID: 15035648 Review.
Hepatobiliary disease occurs in about 10% of cases. Three types of hepatobiliary disease have been observed: liver failure occurring at birth or in utero, transient conjugated hyperbilirubinemia occurring in infants, or transient transaminase elevations occur …
Hepatobiliary disease occurs in about 10% of cases. Three types of hepatobiliary disease have been observed: liver failure occurring …
The canalicular multispecific organic anion transporter and conjugated hyperbilirubinemia in rat and man.
Paulusma CC, Oude Elferink RP. Paulusma CC, et al. J Mol Med (Berl). 1997 Jun;75(6):420-8. doi: 10.1007/s001090050127. J Mol Med (Berl). 1997. PMID: 9231882 Review.
The human Dubin-Johnson syndrome is an autosomal recessive liver disease characterized by a chronic conjugated hyperbilirubinemia. Patients have impaired hepatobiliary transport of many endogenous and xenobiotic compounds. ...A mutation in the cMOAT gene is responsi …
The human Dubin-Johnson syndrome is an autosomal recessive liver disease characterized by a chronic conjugated hyperbilirubinemia …
I index is not an accurate indicator of icteria in conjugated hyperbilirubinemia.
Nikolac Gabaj N, Miler M, Mihic R. Nikolac Gabaj N, et al. Clin Chim Acta. 2017 Oct;473:32-34. doi: 10.1016/j.cca.2017.08.013. Epub 2017 Aug 12. Clin Chim Acta. 2017. PMID: 28811238
RESULTS: In samples where percentage of direct bilirubin accounts for <50% of total bilirubin there was no statistically significant constant difference, while small proportional difference was observed (2.5%) between total bilirubin and I index. In samples where percen …
RESULTS: In samples where percentage of direct bilirubin accounts for <50% of total bilirubin there was no statistically significant cons …
Clinical Profile of Children With Cystic Fibrosis Surviving Through Adolescence and Beyond.
Kumar A, Aggarwal B, Bamal P, Jat KR, Lodha R, Kabra SK. Kumar A, et al. Indian Pediatr. 2022 Jan 15;59(1):43-45. Epub 2021 Sep 4. Indian Pediatr. 2022. PMID: 34480466 Free article.
Allergic bronchopulmonary aspergillosis (ABPA) and Cystic fibrosis-related diabetes (CFRD) were seen in 12 (28%) and 11 (26%) patients, respectively. Conjugated hyperbilirubinemia and distal intestinal obstruction syndrome (DIOS) were diagnosed in 15 (35%) and 6 (14 …
Allergic bronchopulmonary aspergillosis (ABPA) and Cystic fibrosis-related diabetes (CFRD) were seen in 12 (28%) and 11 (26%) patients, resp …
Predictors of irinotecan toxicity and efficacy in treatment of metastatic colorectal cancer.
Paulík A, Grim J, Filip S. Paulík A, et al. Acta Medica (Hradec Kralove). 2012;55(4):153-9. doi: 10.14712/18059694.2015.39. Acta Medica (Hradec Kralove). 2012. PMID: 23631285 Free article. Review.
The patients carrying the mutation of the gene encoding UGT1A enzyme lack the ability of bilirubin glucuronidation, and suffer from the inherited un-conjugated hyperbilirubinemia (Gilbert syndrome, Crigler-Najjar type 1 and 2 syndrome). ...The goal of the contempora …
The patients carrying the mutation of the gene encoding UGT1A enzyme lack the ability of bilirubin glucuronidation, and suffer from the inhe …
Abnormal liver transaminases and conjugated hyperbilirubinemia at presentation of acute lymphoblastic leukemia.
Segal I, Rassekh SR, Bond MC, Senger C, Schreiber RA. Segal I, et al. Pediatr Blood Cancer. 2010 Sep;55(3):434-9. doi: 10.1002/pbc.22549. Pediatr Blood Cancer. 2010. PMID: 20658613
Risk factors for elevated transaminases included a high WBC count at diagnosis, older age, bulky disease, and T-cell leukemia. Conjugated hyperbilirubinemia was observed in 3.4% of subjects. Of these cases, 60% received steroids prior to induction chemotherap …
Risk factors for elevated transaminases included a high WBC count at diagnosis, older age, bulky disease, and T-cell leukemia. Conjugated …
58 results