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Predict overall survival of spinal conventional chordoma: Development and assessment of a new predictive nomogram.
Lin K, Song K, Wang S, Jiang L, Wang H, Dong J. Lin K, et al. Clin Neurol Neurosurg. 2020 Oct;197:106174. doi: 10.1016/j.clineuro.2020.106174. Epub 2020 Aug 22. Clin Neurol Neurosurg. 2020. PMID: 32889324
OBJECTIVE: To predict the 5-year overall survival (OS) rate in patients with conventional chordoma of the spine PATIENTS AND METHODS: The Surveillance, Epidemiology, and End Results (SEER) Registry was used to identify patients with conventional chordoma
OBJECTIVE: To predict the 5-year overall survival (OS) rate in patients with conventional chordoma of the spine PATIENTS AND M …
Differences in stromal component of chordoma are associated with contrast enhancement in MRI and differential gene expression in RNA sequencing.
Park M, Park I, Hong CK, Kim SH, Cha YJ. Park M, et al. Sci Rep. 2022 Oct 3;12(1):16504. doi: 10.1038/s41598-022-20787-3. Sci Rep. 2022. PMID: 36192442 Free PMC article.
Here, we aimed to investigate the histologic, radiologic, and transcriptomic differences in conventional chordoma based on the stromal component. A total of 45 patients diagnosed with conventional chordoma were selected between May 2011 and March 2020 …
Here, we aimed to investigate the histologic, radiologic, and transcriptomic differences in conventional chordoma based on the …
Clinicopathological characteristics of chordoma: an institutional experience and a review of the literature.
Makhdoomi R, Ramzan A, Khursheed N, Bhat S, Baba K, Mohsin R, Basharat M, Yameen B, Ahmad R, Iqbal L, Maqbool M, Ajaz H, Farhat M. Makhdoomi R, et al. Turk Neurosurg. 2013;23(6):700-6. doi: 10.5137/1019-5149.JTN.5941-12.3. Turk Neurosurg. 2013. PMID: 24310451 Free article.
Sacrum was the commonest site involved. Histopathologically, the majority of cases were conventional chordoma with four cases of chondroid variety. There was a single case of dedifferentiated chordoma that presented with bone metastasis. ...
Sacrum was the commonest site involved. Histopathologically, the majority of cases were conventional chordoma with four cases …
Prognostic factors in the operative management of dedifferentiated sacral chordomas.
Kayani B, Sewell MD, Hanna SA, Saifuddin A, Aston W, Pollock R, Skinner J, Molloy S, Briggs TW. Kayani B, et al. Neurosurgery. 2014 Sep;75(3):269-75; discussion 275. doi: 10.1227/NEU.0000000000000423. Neurosurgery. 2014. PMID: 24867206
Tumor size >10 cm in diameter, amount of dedifferentiation within the conventional chordoma, sacroiliac joint infiltration, and inadequate resection margins were associated with increased risk of recurrence and reduced survival. ...
Tumor size >10 cm in diameter, amount of dedifferentiation within the conventional chordoma, sacroiliac joint infiltration, …
Treatment of dedifferentiated chordoma: a retrospective study from a large volume cancer center.
Nachwalter RN, Rothrock RJ, Katsoulakis E, Gounder MM, Boland PJ, Bilsky MH, Laufer I, Schmitt AM, Yamada Y, Higginson DS. Nachwalter RN, et al. J Neurooncol. 2019 Sep;144(2):369-376. doi: 10.1007/s11060-019-03239-3. Epub 2019 Jul 23. J Neurooncol. 2019. PMID: 31338785 Free PMC article.
CONCLUSION: DC patients exhibit significantly higher rates of both synchronous and metachronous metastases, as well as shorter overall survival rates compared to conventional chordoma. The relatively poor survival outcomes with conventional therapies indicate the ne …
CONCLUSION: DC patients exhibit significantly higher rates of both synchronous and metachronous metastases, as well as shorter overall survi …
Loss of H3K27 trimethylation in a distinct group of de-differentiated chordoma of the skull base.
Makise N, Shimoi T, Sunami K, Aoyagi Y, Kobayashi H, Tanaka S, Kawai A, Yonemori K, Ushiku T, Yoshida A. Makise N, et al. Histopathology. 2023 Feb;82(3):420-430. doi: 10.1111/his.14823. Epub 2022 Oct 26. Histopathology. 2023. PMID: 36217885
De-differentiated chordoma is defined as a high-grade sarcoma lacking notochordal differentiation, which arises in association with conventional chordoma. The mechanism underlying de-differentiation remains unclear. ...Five tumours retained H3K27me3, whereas four sh …
De-differentiated chordoma is defined as a high-grade sarcoma lacking notochordal differentiation, which arises in association with conve
Clinical and histopathologic features of chordomas in children and young adults.
Ridenour RV 3rd, Ahrens WA, Folpe AL, Miller DV. Ridenour RV 3rd, et al. Pediatr Dev Pathol. 2010 Jan-Feb;13(1):9-17. doi: 10.2350/09-01-0584.1. Pediatr Dev Pathol. 2010. PMID: 19348512
Histopathology ranged from low cellularity tumors with lobulated architecture and abundant myxoid matrix (conventional chordoma), to those with varying amounts of chondroid matrix (chondroid chordoma), to more cellular tumors (atypical chordoma), and finally to neop …
Histopathology ranged from low cellularity tumors with lobulated architecture and abundant myxoid matrix (conventional chordoma
Stereotactic radiosurgery in the management of skull base chordomas: a comprehensive systematic review and meta-analysis.
Maroufi SF, Fallahi MS, Sabahi M, Maroufi SP, Sheehan JP. Maroufi SF, et al. Neurosurg Focus. 2024 May;56(5):E10. doi: 10.3171/2024.2.FOCUS249. Neurosurg Focus. 2024. PMID: 38691855
Patients, predominantly male (57.37%) with a mean age of 46.54 years, exhibited a conventional chordoma subtype (74.77%) and primary lesions (77.91%), mainly in the clivus (98.04%). ...
Patients, predominantly male (57.37%) with a mean age of 46.54 years, exhibited a conventional chordoma subtype (74.77%) and p …