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Quoted phrase not found in phrase index: "Corneal dystrophy, Meesmann, 1"
Page 1
Photorefractive Keratectomy With Mitomycin C in Meesmann's Epithelial Corneal Dystrophy.
Ghanem RC, Piccinini AL, Ghanem VC. Ghanem RC, et al. J Refract Surg. 2017 Jan 1;33(1):53-55. doi: 10.3928/1081597X-20161027-03. J Refract Surg. 2017. PMID: 28068448
PURPOSE: To describe a case of Meesmann's epithelial corneal dystrophy that underwent photorefractive keratectomy (PRK) with mitomycin C. ...Biomicroscopy revealed bilateral micro-cystic epithelial lesions and a diagnosis of Meesmann's …
PURPOSE: To describe a case of Meesmann's epithelial corneal dystrophy that underwent photorefractive keratectom …
Severe Meesmann's epithelial corneal dystrophy phenotype due to a missense mutation in the helix-initiation motif of keratin 12.
Hassan H, Thaung C, Ebenezer ND, Larkin G, Hardcastle AJ, Tuft SJ. Hassan H, et al. Eye (Lond). 2013 Mar;27(3):367-73. doi: 10.1038/eye.2012.261. Epub 2012 Dec 7. Eye (Lond). 2013. PMID: 23222558 Free PMC article.
PURPOSE: To describe a severe phenotype of Meesmann's epithelial corneal dystrophy (MECD) and to determine the underlying molecular cause. ...In some individuals, the cornea became superficially vascularized, a change accompanied by the loss of clinica …
PURPOSE: To describe a severe phenotype of Meesmann's epithelial corneal dystrophy (MECD) and to determine the u …
Keratin 12 missense mutation induces the unfolded protein response and apoptosis in Meesmann epithelial corneal dystrophy.
Allen EH, Courtney DG, Atkinson SD, Moore JE, Mairs L, Poulsen ET, Schiroli D, Maurizi E, Cole C, Hickerson RP, James J, Murgatroyd H, Smith FJ, MacEwen C, Enghild JJ, Nesbit MA, Leslie Pedrioli DM, McLean WH, Moore CB. Allen EH, et al. Hum Mol Genet. 2016 Mar 15;25(6):1176-91. doi: 10.1093/hmg/ddw001. Epub 2016 Jan 11. Hum Mol Genet. 2016. PMID: 26758872 Free PMC article.
Meesmann epithelial corneal dystrophy (MECD) is a rare autosomal dominant disorder caused by dominant-negative mutations within the KRT3 or KRT12 genes, which encode the cytoskeletal protein keratins K3 and K12, respectively. ...Although the most sever …
Meesmann epithelial corneal dystrophy (MECD) is a rare autosomal dominant disorder caused by dominant-negative m …
In vivo histology and p.L132V mutation in KRT12 gene in Japanese patients with Meesmann corneal dystrophy.
Nishino T, Kobayashi A, Mori N, Masaki T, Yokogawa H, Fujiki K, Yanagawa A, Murakami A, Sugiyama K. Nishino T, et al. Jpn J Ophthalmol. 2019 Jan;63(1):46-55. doi: 10.1007/s10384-018-00643-6. Epub 2018 Dec 7. Jpn J Ophthalmol. 2019. PMID: 30535821
This is the first study to confirm this genetic mutation in Japanese Meesmann corneal dystrophy patients. This mutation has been independently reported in an American Meesmann corneal dystrophy patient, confirming its pathogenicity. AS-OC …
This is the first study to confirm this genetic mutation in Japanese Meesmann corneal dystrophy patients. This mutation …
Identification of presumed pathogenic KRT3 and KRT12 gene mutations associated with Meesmann corneal dystrophy.
Chen JL, Lin BR, Gee KM, Gee JA, Chung DW, Frausto RF, Deng SX, Aldave AJ. Chen JL, et al. Mol Vis. 2015 Dec 31;21:1378-86. eCollection 2015. Mol Vis. 2015. PMID: 26788030 Free PMC article.
PURPOSE: To report potentially pathogenic mutations in the keratin 3 (KRT3) and keratin 12 (KRT12) genes in two individuals with clinically diagnosed Meesmann corneal dystrophy (MECD). METHODS: Slit-lamp examination was performed on the probands and available …
PURPOSE: To report potentially pathogenic mutations in the keratin 3 (KRT3) and keratin 12 (KRT12) genes in two individuals with clinically …
KRT12 mutations and in vivo confocal microscopy in two Japanese families with Meesmann corneal dystrophy.
Ogasawara M, Matsumoto Y, Hayashi T, Ohno K, Yamada H, Kawakita T, Dogru M, Shimazaki J, Tsubota K, Tsuneoka H. Ogasawara M, et al. Am J Ophthalmol. 2014 Jan;157(1):93-102.e1. doi: 10.1016/j.ajo.2013.08.008. Epub 2013 Oct 5. Am J Ophthalmol. 2014. PMID: 24099278
PURPOSE: To identify genetic mutations and study the corneal epithelium in Japanese patients with Meesmann corneal dystrophy. ...CONCLUSIONS: We identified a novel missense mutation of the KRT12 gene in Meesmann corneal dystrophy. …
PURPOSE: To identify genetic mutations and study the corneal epithelium in Japanese patients with Meesmann corneal d …
Molecular genetics of Meesmann's corneal dystrophy: ancestral and novel mutations in keratin 12 (K12) and complete sequence of the human KRT12 gene.
Corden LD, Swensson O, Swensson B, Smith FJ, Rochels R, Uitto J, McLEAN WH. Corden LD, et al. Exp Eye Res. 2000 Jan;70(1):41-9. doi: 10.1006/exer.1999.0769. Exp Eye Res. 2000. PMID: 10644419
Recently, we identified the first mutations in corneal keratins K3 and K12 in families with Meesmann's corneal dystrophy (MCD). ...A novel mutation was detected in an American kindred, 410T-->C, which predicts the amino acid substitution M129 …
Recently, we identified the first mutations in corneal keratins K3 and K12 in families with Meesmann's corneal dystr …
siRNA silencing of the mutant keratin 12 allele in corneal limbal epithelial cells grown from patients with Meesmann's epithelial corneal dystrophy.
Courtney DG, Atkinson SD, Allen EH, Moore JE, Walsh CP, Pedrioli DM, MacEwen CJ, Pellegrini G, Maurizi E, Serafini C, Fantacci M, Liao H, Irvine AD, McLean WH, Moore CB. Courtney DG, et al. Invest Ophthalmol Vis Sci. 2014 May 6;55(5):3352-60. doi: 10.1167/iovs.13-12957. Invest Ophthalmol Vis Sci. 2014. PMID: 24801514
PURPOSE: The aim of this study is to further assess our previously reported keratin 12 (K12)-Leu132Pro specific siRNA in silencing the mutant allele in Meesmann's Epithelial Corneal Dystrophy (MECD) in experimental systems more akin to the in vivo situ …
PURPOSE: The aim of this study is to further assess our previously reported keratin 12 (K12)-Leu132Pro specific siRNA in silencing the mutan …
Novel mutations in the helix termination motif of keratin 3 and keratin 12 in 2 Taiwanese families with Meesmann corneal dystrophy.
Chen YT, Tseng SH, Chao SC. Chen YT, et al. Cornea. 2005 Nov;24(8):928-32. doi: 10.1097/01.ico.0000159732.29930.26. Cornea. 2005. PMID: 16227835
PURPOSE: To analyze mutations of the keratin 3 gene (KRT3) and keratin 12 gene (KRT12) in 2 Taiwanese families with Meesmann corneal dystrophy (MCD). METHODS: Diagnosis of MCD was confirmed by slit-lamp examination of the cornea in 4 members of family 1 …
PURPOSE: To analyze mutations of the keratin 3 gene (KRT3) and keratin 12 gene (KRT12) in 2 Taiwanese families with Meesmann corne …
Microcysts: clinical significance and differential diagnosis.
Keay L, Jalbert I, Sweeney DF, Holden BA. Keay L, et al. Optometry. 2001 Jul;72(7):452-60. Optometry. 2001. PMID: 11486940 Review.
They should not be confused with cyst-like inclusions that occur in conditions such as Meesmann's dystrophy, bullous keratopathy, and Cogan's microcystic dystrophy, or with mucin balls, vacuoles, microcystic edema, and infiltrates. ...CONCLUSIONS: Microcysts …
They should not be confused with cyst-like inclusions that occur in conditions such as Meesmann's dystrophy, bullous keratopat …
13 results