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Quoted phrase not found in phrase index: "Coronary artery disease, autosomal dominant 2"
Page 1
Aortic valve and arterial calcification in patients with familial hypercholesterolemia.
Waluś-Miarka M, Polus A, Idzior-Waluś B. Waluś-Miarka M, et al. Kardiol Pol. 2024;82(2):144-155. doi: 10.33963/v.phj.98945. Epub 2024 Feb 13. Kardiol Pol. 2024. PMID: 38348620 Free article. Review.
Heterozygous familial hypercholesterolemia (heFH) is an autosomal dominant lipid metabolism disorder. Its prevalence is 1:250-1:300 people in the population. Patients with heFH have an up to 13-fold increased risk of premature coronary artery diseas …
Heterozygous familial hypercholesterolemia (heFH) is an autosomal dominant lipid metabolism disorder. Its prevalence is 1:250- …
Pediatric Drug Development Studies for Familial Hypercholesterolemia Submitted to the US Food and Drug Administration Between 2007 and 2020.
Park K, Vishnevetskaya K, Vaidyanathan J, Burckart GJ, Green DJ. Park K, et al. J Clin Pharmacol. 2022 Mar;62(3):397-408. doi: 10.1002/jcph.1973. Epub 2021 Oct 19. J Clin Pharmacol. 2022. PMID: 34562277 Review.
Familial hypercholesterolemia (FH) is an autosomal dominant genetic disorder of lipoprotein metabolism that leads to an increased risk of developing atherosclerosis and coronary artery disease. ...Most of the trials included pediatric patients 1 …
Familial hypercholesterolemia (FH) is an autosomal dominant genetic disorder of lipoprotein metabolism that leads to an increa …
The genetics of autosomal dominant familial hypercholesterolemia.
Anderson S, Botti C. Anderson S, et al. J Am Assoc Nurse Pract. 2024 Feb 1;36(2):136-142. doi: 10.1097/JXX.0000000000000930. J Am Assoc Nurse Pract. 2024. PMID: 37624754
Affected individuals are unable to metabolize cholesterol due to inherited changes in the low-density lipoprotein (LDL) receptor, which impairs the ability to metabolize cholesterol, resulting in extremely high levels of cholesterol that leads to premature coronary arte …
Affected individuals are unable to metabolize cholesterol due to inherited changes in the low-density lipoprotein (LDL) receptor, which impa …
New data on familial hypercholesterolaemia and acute coronary syndromes: The promise of PCSK9 monoclonal antibodies in the light of recent clinical trials.
Ellis KL, Pang J, Schultz CJ, Watts GF. Ellis KL, et al. Eur J Prev Cardiol. 2017 Jul;24(11):1200-1205. doi: 10.1177/2047487317708890. Epub 2017 May 9. Eur J Prev Cardiol. 2017. PMID: 28482694 Review.
Methods The purpose of this commentary is to provide a brief update on recent data investigating several key aspects of FH in patients with acute coronary syndromes, including prevalence, risk of coronary artery disease, molecular diagnosis, cardiac im …
Methods The purpose of this commentary is to provide a brief update on recent data investigating several key aspects of FH in patients with …
Prevalence, clinical features and prognosis of familial hypercholesterolemia in Chinese Han patients with acute coronary syndrome after a coronary event: a retrospective observational study.
Kou H, Wang H, Liu P, Wang X, Zhu W, Jiang W, Hu X, Deng J. Kou H, et al. BMC Cardiovasc Disord. 2024 Mar 5;24(1):144. doi: 10.1186/s12872-024-03803-4. BMC Cardiovasc Disord. 2024. PMID: 38443803 Free PMC article.
BACKGROUND: Familial hypercholesterolemia (FH) is an autosomal semi-dominant disease, characterized by markedly elevated levels of low-density lipoprotein cholesterol (LDL-c) from conception and accelerated atherosclerotic cardiovascular disease, often …
BACKGROUND: Familial hypercholesterolemia (FH) is an autosomal semi-dominant disease, characterized by markedly elevate …
The efficacy of colesevelam HCl in the treatment of heterozygous familial hypercholesterolemia in pediatric and adult patients.
Davidson M. Davidson M. Clin Ther. 2013 Aug;35(8):1247-52. doi: 10.1016/j.clinthera.2013.06.014. Epub 2013 Jul 31. Clin Ther. 2013. PMID: 23916045 Review.
BACKGROUND: Familial hypercholesterolemia (FH) is a common autosomal co-dominant genetic disorder that results in severely increased levels of LDL-C. Patients with FH are at an increased risk for premature coronary artery disease. Expert panels …
BACKGROUND: Familial hypercholesterolemia (FH) is a common autosomal co-dominant genetic disorder that results in severely inc …
Acute coronary syndrome in an 8-year-old child with familial hypercholesterolemia: a case report.
Wang N, Wei Y, Zhou G, Zhang Y, Song J. Wang N, et al. J Med Case Rep. 2022 Jul 26;16(1):290. doi: 10.1186/s13256-022-03488-3. J Med Case Rep. 2022. PMID: 35879787 Free PMC article.
BACKGROUND: Familial hypercholesterolemia (FH) is the most commonly inherited metabolic disease and has an autosomal dominant mode of inheritance. Patients with FH usually present with high levels of low-density lipoprotein-cholesterol, xanthomas and early …
BACKGROUND: Familial hypercholesterolemia (FH) is the most commonly inherited metabolic disease and has an autosomal domina …
Suboptimal consideration and management of potential familial hypercholesterolaemia in patients with suspected premature coronary artery disease.
Yudi M, Omera L, McCubbery N, Dick S, Jayasinghe R, Hamilton-Craig I. Yudi M, et al. Singapore Med J. 2012 Mar;53(3):174-8. Singapore Med J. 2012. PMID: 22434290 Free article.
INTRODUCTION: Familial hypercholesterolaemia (FH) is caused by an autosomal dominant mutation of the low density lipoprotein (LDL) receptor gene, resulting in high levels of LDL cholesterol and premature coronary artery disease (P-CAD). ...Only …
INTRODUCTION: Familial hypercholesterolaemia (FH) is caused by an autosomal dominant mutation of the low density lipoprotein ( …
Characterization of Autosomal Dominant Hypercholesterolemia Caused by PCSK9 Gain of Function Mutations and Its Specific Treatment With Alirocumab, a PCSK9 Monoclonal Antibody.
Hopkins PN, Defesche J, Fouchier SW, Bruckert E, Luc G, Cariou B, Sjouke B, Leren TP, Harada-Shiba M, Mabuchi H, Rabès JP, Carrié A, van Heyningen C, Carreau V, Farnier M, Teoh YP, Bourbon M, Kawashiri MA, Nohara A, Soran H, Marais AD, Tada H, Abifadel M, Boileau C, Chanu B, Katsuda S, Kishimoto I, Lambert G, Makino H, Miyamoto Y, Pichelin M, Yagi K, Yamagishi M, Zair Y, Mellis S, Yancopoulos GD, Stahl N, Mendoza J, Du Y, Hamon S, Krempf M, Swergold GD. Hopkins PN, et al. Circ Cardiovasc Genet. 2015 Dec;8(6):823-31. doi: 10.1161/CIRCGENETICS.115.001129. Epub 2015 Sep 15. Circ Cardiovasc Genet. 2015. PMID: 26374825 Free PMC article. Clinical Trial.
BACKGROUND: Patients with PCSK9 gene gain of function (GOF) mutations have a rare form of autosomal dominant hypercholesterolemia. However, data examining their clinical characteristics and geographic distribution are lacking. ...Observational study: among 16 …
BACKGROUND: Patients with PCSK9 gene gain of function (GOF) mutations have a rare form of autosomal dominant hypercholesterole …
Hyperlipidemia patients carrying LDLR splicing mutation c.1187-2A>G respond favorably to rosuvastatin and PCSK9 inhibitor evolocumab.
Zhang X, Liu Q, Zhang H, Tan C, Zhu Q, Chen S, Du Y, Yang H, Li Q, Xu C, Wu C, Wang QK. Zhang X, et al. Mol Genet Genomics. 2022 May;297(3):833-841. doi: 10.1007/s00438-022-01892-4. Epub 2022 Apr 19. Mol Genet Genomics. 2022. PMID: 35441343
The goals of this study were to identify the genetic cause of a three-generation Chinese family affected with autosomal dominant FH, and to investigate the response of FH patients in the family to statin and evolocumab. ...A combination of life style modifications o …
The goals of this study were to identify the genetic cause of a three-generation Chinese family affected with autosomal dominant …
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