Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1983 1
1991 1
1996 1
1999 1
2002 1
2004 1
2006 1
2007 1
2008 2
2009 1
2010 4
2011 5
2012 3
2013 2
2014 3
2015 3
2018 1
2020 1
2021 4
2022 1
2023 3
2024 0

Text availability

Article attribute

Article type

Publication date

Search Results

36 results

Results by year

Filters applied: . Clear all
Quoted phrase not found in phrase index: "Decreased activity of mitochondrial complex I"
Page 1
Excessive O-GlcNAcylation Causes Heart Failure and Sudden Death.
Umapathi P, Mesubi OO, Banerjee PS, Abrol N, Wang Q, Luczak ED, Wu Y, Granger JM, Wei AC, Reyes Gaido OE, Florea L, Talbot CC Jr, Hart GW, Zachara NE, Anderson ME. Umapathi P, et al. Circulation. 2021 Apr 27;143(17):1687-1703. doi: 10.1161/CIRCULATIONAHA.120.051911. Epub 2021 Feb 17. Circulation. 2021. PMID: 33593071 Free PMC article.
Total levels of O-GlcNAcylation are determined by nutrient and metabolic flux, in addition to the net activity of 2 enzymes: O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA). ...Transcriptomic and functional studies revealed disrupted mitochondrial energetics with impairme …
Total levels of O-GlcNAcylation are determined by nutrient and metabolic flux, in addition to the net activity of 2 enzymes: O-GlcNAc …
The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity.
Cantó C, Houtkooper RH, Pirinen E, Youn DY, Oosterveer MH, Cen Y, Fernandez-Marcos PJ, Yamamoto H, Andreux PA, Cettour-Rose P, Gademann K, Rinsch C, Schoonjans K, Sauve AA, Auwerx J. Cantó C, et al. Cell Metab. 2012 Jun 6;15(6):838-47. doi: 10.1016/j.cmet.2012.04.022. Cell Metab. 2012. PMID: 22682224 Free PMC article.
As NAD(+) is a rate-limiting cosubstrate for the sirtuin enzymes, its modulation is emerging as a valuable tool to regulate sirtuin function and, consequently, oxidative metabolism. In line with this premise, decreased activity of PARP-1 or CD38-both NAD(+) consumer …
As NAD(+) is a rate-limiting cosubstrate for the sirtuin enzymes, its modulation is emerging as a valuable tool to regulate sirtuin function …
Combination of metformin/efavirenz/fluoxetine exhibits profound anticancer activity via a cancer cell-specific ROS amplification.
Kang BG, Shende M, Inci G, Park SH, Jung JS, Kim SB, Kim JH, Mo YW, Seo JH, Feng JH, Kim SC, Lim SS, Suh HW, Lee JY. Kang BG, et al. Cancer Biol Ther. 2023 Dec 31;24(1):20-32. doi: 10.1080/15384047.2022.2161803. Cancer Biol Ther. 2023. PMID: 36588385 Free PMC article.
The possible anticancer activity of combination (M + E + F) of metformin (M), efavirenz (E), and fluoxetine (F) was investigated in normal HDF cells and HCT116 human colon cancer cells. ...Transfection of si-FOXO3a into HCT116 reversed the metformin-induced cellular ROS in …
The possible anticancer activity of combination (M + E + F) of metformin (M), efavirenz (E), and fluoxetine (F) was investigated in n …
Parkinson's disease and mitochondrial complex I: a perspective on the Ndi1 therapy.
Marella M, Seo BB, Yagi T, Matsuno-Yagi A. Marella M, et al. J Bioenerg Biomembr. 2009 Dec;41(6):493-7. doi: 10.1007/s10863-009-9249-z. J Bioenerg Biomembr. 2009. PMID: 19904590 Free PMC article. Review.
Complex I dysfunction is translated to an increased production of reactive oxygen species and a decreased energy supply. In the brain, the dopaminergic neurons are one of the most susceptible cells. ...To overcome this problem a therapeutic candidate must be able to restor …
Complex I dysfunction is translated to an increased production of reactive oxygen species and a decreased energy supply. In the brain …
Phenylethynylbenzyl-modified biguanides inhibit pancreatic cancer tumor growth.
Hébert A, Parisotto M, Rowell MC, Doré A, Fernandez Ruiz A, Lefrançois G, Kalegari P, Ferbeyre G, Schmitzer AR. Hébert A, et al. Sci Rep. 2021 May 10;11(1):9854. doi: 10.1038/s41598-021-87993-3. Sci Rep. 2021. PMID: 33972583 Free PMC article.
We show that phenylethynyl biguanidium salts possess higher ability to cross hydrophobic barriers, improve mitochondrial accumulation and anticancer activity. Mechanistically, the most active compound, 1b, like metformin, activated AMPK, decreased the NAD(+)/NADH ra …
We show that phenylethynyl biguanidium salts possess higher ability to cross hydrophobic barriers, improve mitochondrial accumulation and an …
Dietary Oxalate Loading Impacts Monocyte Metabolism and Inflammatory Signaling in Humans.
Kumar P, Patel M, Oster RA, Yarlagadda V, Ambrosetti A, Assimos DG, Mitchell T. Kumar P, et al. Front Immunol. 2021 Feb 25;12:617508. doi: 10.3389/fimmu.2021.617508. eCollection 2021. Front Immunol. 2021. PMID: 33732242 Free PMC article.
Monocyte cellular bioenergetics, mitochondrial complex I activity, and plasma cytokine and chemokine levels were altered to varying degrees within the study cohort. ...Further studies are warranted to understand oxalate mediated mechanisms on circulati …
Monocyte cellular bioenergetics, mitochondrial complex I activity, and plasma cytokine and chemokine levels were …
Vitamin D3 actions on astrocyte cells: A target for therapeutic strategy in Parkinson's disease?
de Siqueira EA, Magalhães EP, de Menezes RRPPB, Sampaio TL, Lima DB, da Silva Martins C, Neves KRT, de Castro Brito GA, Martins AMC, de Barros Viana GS. de Siqueira EA, et al. Neurosci Lett. 2023 Jan 10;793:136997. doi: 10.1016/j.neulet.2022.136997. Epub 2022 Dec 2. Neurosci Lett. 2023. PMID: 36470505
PD patients' brains show neuroinflammation, oxidative stress, and mitochondrial dysfunction. The present study aims to evaluate the neuroprotective activity of VD3 on astrocytes after their exposure to rotenone (ROT) a natural pesticide known to exhibit neurotoxic potentia …
PD patients' brains show neuroinflammation, oxidative stress, and mitochondrial dysfunction. The present study aims to evaluate the neuropro …
Mitochondrial complex I defect induces ROS release and degeneration in trabecular meshwork cells of POAG patients: protection by antioxidants.
He Y, Leung KW, Zhang YH, Duan S, Zhong XF, Jiang RZ, Peng Z, Tombran-Tink J, Ge J. He Y, et al. Invest Ophthalmol Vis Sci. 2008 Apr;49(4):1447-58. doi: 10.1167/iovs.07-1361. Invest Ophthalmol Vis Sci. 2008. PMID: 18385062
Reactive oxygen species (ROS) level, determined by H(2)-DCF-DA, and cell death, measured by lactate dehydrogenase activity and Annexin V-FITC labeling, were also examined. RESULTS: GTM cells have higher endogenous ROS levels, lower ATP levels, and decreased Delta Ps …
Reactive oxygen species (ROS) level, determined by H(2)-DCF-DA, and cell death, measured by lactate dehydrogenase activity and Annexi …
The link between mitochondrial complex I and brain-derived neurotrophic factor in SH-SY5Y cells--The potential of JNX1001 as a therapeutic agent.
Kim HK, Mendonça KM, Howson PA, Brotchie JM, Andreazza AC. Kim HK, et al. Eur J Pharmacol. 2015 Oct 5;764:379-384. doi: 10.1016/j.ejphar.2015.07.013. Epub 2015 Jul 8. Eur J Pharmacol. 2015. PMID: 26164791
Mitochondrial complex I, which is the first member of the electron transport chain responsible for producing ATP, can produce reactive oxygen species and oxidative stress when it becomes dysfunctional. ...JNX1001, a clinical trial ready brain pe …
Mitochondrial complex I, which is the first member of the electron transport chain responsible for producing ATP, can p …
Neuromuscular electrical stimulation resistance training enhances oxygen uptake and ventilatory efficiency independent of mitochondrial complexes after spinal cord injury: a randomized clinical trial.
Gorgey AS, Lai RE, Khalil RE, Rivers J, Cardozo C, Chen Q, Lesnefsky EJ. Gorgey AS, et al. J Appl Physiol (1985). 2021 Jul 1;131(1):265-276. doi: 10.1152/japplphysiol.01029.2020. Epub 2021 May 13. J Appl Physiol (1985). 2021. PMID: 33982590 Free PMC article. Clinical Trial.
In conclusion, in persons with SCI, NMES-RT-induced skeletal muscle hypertrophy was accompanied by increased peak Vo(2) consumption which may partially be explained by enhanced activity of mitochondrial complex I.NEW & NOTEWORTHY Leg oxygen uptake …
In conclusion, in persons with SCI, NMES-RT-induced skeletal muscle hypertrophy was accompanied by increased peak Vo(2) consumption which ma …
36 results