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Interleukin 17 signaling supports clinical benefit of dual CTLA-4 and PD-1 checkpoint inhibition in melanoma.
Váraljai R, Zimmer L, Al-Matary Y, Kaptein P, Albrecht LJ, Shannan B, Brase JC, Gusenleitner D, Amaral T, Wyss N, Utikal J, Flatz L, Rambow F, Reinhardt HC, Dick J, Engel DR, Horn S, Ugurel S, Sondermann W, Livingstone E, Sucker A, Paschen A, Zhao F, Placke JM, Klose JM, Fendler WP, Thommen DS, Helfrich I, Schadendorf D, Roesch A. Váraljai R, et al. Nat Cancer. 2023 Sep;4(9):1292-1308. doi: 10.1038/s43018-023-00610-2. Epub 2023 Jul 31. Nat Cancer. 2023. PMID: 37525015 Free PMC article.
Here we identified an over-representation of interleukin (IL)-17-type 17 helper T (T(H)17) gene expression signatures (GES) in BRAF(V600)-mutated tumors. Moreover, high baseline IL-17 GES consistently predicted clinical responses in dual-ICI-treated patient cohorts but not …
Here we identified an over-representation of interleukin (IL)-17-type 17 helper T (T(H)17) gene expression signatures (GES) in BRAF(V600)-mu …
Combined multi-omics and network pharmacology approach reveals the role of Tripterygium Wilfordii Hook F in treating HIV immunological non-responders.
Liu X, Lin L, Lv T, Lu L, Li X, Han Y, Qiu Z, Li X, Li Y, Song X, Cao W, Li T. Liu X, et al. Phytomedicine. 2022 Jul;101:154103. doi: 10.1016/j.phymed.2022.154103. Epub 2022 Apr 17. Phytomedicine. 2022. PMID: 35468451 Free article.
The multi-omics analysis showed that the interferon (IFN)-signaling pathway was significantly inhibited after taking TwHF pills. The network pharmacology predicted the central role of the signal transducer and activator of transcription 1 (STAT1) in the 'TwHF-compounds-tar …
The multi-omics analysis showed that the interferon (IFN)-signaling pathway was significantly inhibited after taking TwHF pills. The network …
Costimulatory function of umbilical cord blood CD14+ and CD34+ derived dendritic cells.
Dilioglou S, Cruse JM, Lewis RE. Dilioglou S, et al. Exp Mol Pathol. 2003 Aug;75(1):18-33. doi: 10.1016/s0014-4800(03)00034-0. Exp Mol Pathol. 2003. PMID: 12834622
The surface expression of CD80 and CD86 was studied over the course of differentiation. Mixed lymphocyte reaction was employed to evaluate the two types of lineage-derived DCs. ...
The surface expression of CD80 and CD86 was studied over the course of differentiation. Mixed lymphocyte reaction was employed to eva …