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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1971 1
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1975 3
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1978 6
1979 4
1980 10
1981 7
1982 7
1983 11
1984 17
1985 13
1986 20
1987 16
1988 14
1989 20
1990 18
1991 16
1992 25
1993 17
1994 19
1995 29
1996 19
1997 18
1998 26
1999 31
2000 22
2001 29
2002 30
2003 27
2004 42
2005 24
2006 30
2007 30
2008 36
2009 24
2010 40
2011 44
2012 43
2013 39
2014 43
2015 43
2016 46
2017 64
2018 66
2019 60
2020 57
2021 51
2022 38
2023 40
2024 20

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1,248 results

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Quoted phrase not found in phrase index: "Decreased circulating antibody level"
Page 1
PCSK9 Inhibitors: Mechanism of Action, Efficacy, and Safety.
Roth EM, Davidson MH. Roth EM, et al. Rev Cardiovasc Med. 2018;19(S1):S31-S46. doi: 10.3909/ricm19S1S0002. Rev Cardiovasc Med. 2018. PMID: 30207556 Free article. Review.
Less LDL receptors result in increased LDL-C in the bloodstream but inhibiting or binding the circulating PCSK9 results in increased LDL receptors with the resultant decrease in serum LDL-C. Two PCSK9 inhibitors are currently approved for use: alirocumab and evolocu …
Less LDL receptors result in increased LDL-C in the bloodstream but inhibiting or binding the circulating PCSK9 results in increased …
Monoclonal antibody targeting BDCA2 ameliorates skin lesions in systemic lupus erythematosus.
Furie R, Werth VP, Merola JF, Stevenson L, Reynolds TL, Naik H, Wang W, Christmann R, Gardet A, Pellerin A, Hamann S, Auluck P, Barbey C, Gulati P, Rabah D, Franchimont N. Furie R, et al. J Clin Invest. 2019 Mar 1;129(3):1359-1371. doi: 10.1172/JCI124466. Epub 2019 Feb 18. J Clin Invest. 2019. PMID: 30645203 Free PMC article. Clinical Trial.
All subjects were monitored for adverse events. Serum BIIB059 concentrations, BDCA2 levels on pDCs, and IFN-responsive biomarkers in whole blood and skin biopsies were measured. ...BIIB059 administration led to BDCA2 internalization on pDCs, which correlated with …
All subjects were monitored for adverse events. Serum BIIB059 concentrations, BDCA2 levels on pDCs, and IFN-responsive biomarkers in …
IgG-cleaving endopeptidase enables in vivo gene therapy in the presence of anti-AAV neutralizing antibodies.
Leborgne C, Barbon E, Alexander JM, Hanby H, Delignat S, Cohen DM, Collaud F, Muraleetharan S, Lupo D, Silverberg J, Huang K, van Wittengerghe L, Marolleau B, Miranda A, Fabiano A, Daventure V, Beck H, Anguela XM, Ronzitti G, Armour SM, Lacroix-Desmazes S, Mingozzi F. Leborgne C, et al. Nat Med. 2020 Jul;26(7):1096-1101. doi: 10.1038/s41591-020-0911-7. Epub 2020 Jun 1. Nat Med. 2020. PMID: 32483358 Free article.
In mice passively immunized with intravenous Ig, IdeS administration decreased anti-AAV antibodies and enabled efficient liver gene transfer. ...IdeS treatment before AAV vector infusion was safe and resulted in enhanced liver transduction, even in the setting of ve …
In mice passively immunized with intravenous Ig, IdeS administration decreased anti-AAV antibodies and enabled efficient liver …
PCSK9 inhibitors.
Gencer B, Lambert G, Mach F. Gencer B, et al. Swiss Med Wkly. 2015 Apr 9;145:w14094. doi: 10.4414/smw.2015.14094. eCollection 2015. Swiss Med Wkly. 2015. PMID: 25856746 Free article. Review.
The discovery of proprotein convertase subtilisin kexin 9 (PCSK9) has considerably changed the therapeutic options in the field of lipid management. PCSK9 reduces LDL receptor recycling, leading to a decrease of low-density lipoprotein cholesterol (LDL-C) receptors on the …
The discovery of proprotein convertase subtilisin kexin 9 (PCSK9) has considerably changed the therapeutic options in the field of lipid man …
Anti-IgE treatment in allergic rhinitis.
Bayar Muluk N, Bafaqeeh SA, Cingi C. Bayar Muluk N, et al. Int J Pediatr Otorhinolaryngol. 2019 Dec;127:109674. doi: 10.1016/j.ijporl.2019.109674. Epub 2019 Sep 10. Int J Pediatr Otorhinolaryngol. 2019. PMID: 31526939 Review.
RESULTS: Although the skin prick testing in patients suffering from AR is positive (indicating that antigen-specific Immunoglobulin E has been produced), there is no association with overall circulating IgE levels. Correlation was lacking between circulating …
RESULTS: Although the skin prick testing in patients suffering from AR is positive (indicating that antigen-specific Immunoglobulin E has be …
Treatment of primary Sjogren's syndrome with ianalumab (VAY736) targeting B cells by BAFF receptor blockade coupled with enhanced, antibody-dependent cellular cytotoxicity.
Dörner T, Posch MG, Li Y, Petricoul O, Cabanski M, Milojevic JM, Kamphausen E, Valentin MA, Simonett C, Mooney L, Hüser A, Gram H, Wagner FD, Oliver SJ. Dörner T, et al. Ann Rheum Dis. 2019 May;78(5):641-647. doi: 10.1136/annrheumdis-2018-214720. Epub 2019 Mar 2. Ann Rheum Dis. 2019. PMID: 30826774 Clinical Trial.
Laboratory-based measures included circulating leucocyte subsets and markers of B cell activity. RESULTS: A similar trend showing positive therapeutic effect by ianalumab was observed across the primary clinical outcome (ESSDAI) and all secondary clinical out …
Laboratory-based measures included circulating leucocyte subsets and markers of B cell activity. RESULTS: A similar trend showing pos …
Glycosylation-dependent antitumor therapeutic monoclonal antibodies.
Zhang Y, Fan C, Zhang L, Ma X. Zhang Y, et al. Prog Mol Biol Transl Sci. 2019;163:471-485. doi: 10.1016/bs.pmbts.2019.03.004. Epub 2019 Mar 25. Prog Mol Biol Transl Sci. 2019. PMID: 31030759 Review.
All MAbs typically have a single N-glycosylation site on each of the Fc region. The clinical efficacy of the MAbs depends on the N-glycan structures. Loss of N-glycosylation on the MAbs leads to the loss of the ability to activate complement, to bind to Fc receptors, and t …
All MAbs typically have a single N-glycosylation site on each of the Fc region. The clinical efficacy of the MAbs depends on the N-gl …
Dyslipidemia in systemic lupus erythematosus.
Szabó MZ, Szodoray P, Kiss E. Szabó MZ, et al. Immunol Res. 2017 Apr;65(2):543-550. doi: 10.1007/s12026-016-8892-9. Immunol Res. 2017. PMID: 28168401 Review.
Multiple pathogenetic mechanism is included, C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) can suppress HDL and increase TG, auto-antibodies can cause the injury of the endothelium, lipoprotein lipase (LPL) activity can be reduced by circulating …
Multiple pathogenetic mechanism is included, C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) can suppress HDL and increase …
Selective IgA deficiency.
Yel L. Yel L. J Clin Immunol. 2010 Jan;30(1):10-6. doi: 10.1007/s10875-009-9357-x. Epub 2010 Jan 26. J Clin Immunol. 2010. PMID: 20101521 Free PMC article. Review.
INTRODUCTION: Immunoglobulin A (IgA) deficiency is the most common primary immunodeficiency defined as decreased serum level of IgA in the presence of normal levels of other immunoglobulin isotypes. ...Subclass IgA1 in monomeric form is mainly found in the …
INTRODUCTION: Immunoglobulin A (IgA) deficiency is the most common primary immunodeficiency defined as decreased serum level o …
The Effects of Statin Therapy on Oxidized LDL and Its Antibodies: A Systematic Review and Meta-Analysis.
Jamialahmadi T, Baratzadeh F, Reiner Ž, Mannarino MR, Cardenia V, Simental-Mendía LE, Pirro M, Watts GF, Sahebkar A. Jamialahmadi T, et al. Oxid Med Cell Longev. 2022 Aug 1;2022:7850659. doi: 10.1155/2022/7850659. eCollection 2022. Oxid Med Cell Longev. 2022. PMID: 35958018 Free PMC article. Retracted. Review.
METHODS: PubMed, Scopus, Embase, and Web of Science were searched up to February 5th, 2021, for randomized controlled trials (RCT) evaluating the effect of statins on oxLDL and anti-oxLDL antibody levels. ...CONCLUSION: Statin therapy decreases serum o …
METHODS: PubMed, Scopus, Embase, and Web of Science were searched up to February 5th, 2021, for randomized controlled trials (RCT) ev …
1,248 results