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Quoted phrase not found in phrase index: "Decreased urinary uromodulin level"
Page 1
Mendelian randomization to assess causality between uromodulin, blood pressure and chronic kidney disease.
Ponte B, Sadler MC, Olinger E, Vollenweider P, Bochud M, Padmanabhan S, Hayward C, Kutalik Z, Devuyst O. Ponte B, et al. Kidney Int. 2021 Dec;100(6):1282-1291. doi: 10.1016/j.kint.2021.08.032. Epub 2021 Oct 9. Kidney Int. 2021. PMID: 34634361
UMOD variants associated with higher levels of urinary uromodulin (uUMOD) increase the risk of chronic kidney disease (CKD) and hypertension. ...We used Mendelian randomization to clarify causality between uUMOD levels, kidney function and blood …
UMOD variants associated with higher levels of urinary uromodulin (uUMOD) increase the risk of chronic kidney disease ( …
Uromodulin and microRNAs in Kidney Transplantation-Association with Kidney Graft Function.
Borštnar Š, Večerić-Haler Ž, Boštjančič E, Pipan Tkalec Ž, Kovač D, Lindič J, Kojc N. Borštnar Š, et al. Int J Mol Sci. 2020 Aug 5;21(16):5592. doi: 10.3390/ijms21165592. Int J Mol Sci. 2020. PMID: 32764335 Free PMC article. Clinical Trial.
The selected miRNAs were shown to be independent of kidney graft function, indicating their potential as biomarkers of associated kidney graft disease processes. In contrast, the serum uromodulin level depended entirely on kidney graft function and thus reflected fu …
The selected miRNAs were shown to be independent of kidney graft function, indicating their potential as biomarkers of associated kidney gra …
Associations of plasma uromodulin and genetic variants with blood pressure responses to dietary salt interventions.
Du MF, Yao S, Zou T, Mu JJ, Zhang XY, Hu GL, Chu C, Jia H, Liao YY, Chen C, Wang D, Ma Q, Yan Y, Wang KK, Sun Y, Niu ZJ, Yan RC, Zhang X, Zhou HW, Gao WH, Li H, Li CH, Gao K, Zhang J, Yang TL, Wang Y. Du MF, et al. J Clin Hypertens (Greenwich). 2021 Oct;23(10):1897-1906. doi: 10.1111/jch.14347. Epub 2021 Aug 7. J Clin Hypertens (Greenwich). 2021. PMID: 34363725 Free PMC article.
Daily urinary excretions of uromodulin were significantly decreased on a high-salt diet than on a low-salt diet (28.7 6.7 vs. 157.2 21.7 ng/ml). ...This study shows that dietary salt intake affects plasma and urinary uromodulin levels and …
Daily urinary excretions of uromodulin were significantly decreased on a high-salt diet than on a low-salt diet (28.7 6 …
Pregnancy-associated changes in urinary uromodulin excretion in chronic hypertension.
Mary S, Conti-Ramsden F, Boder P, Parveen H, Setjiadi D, Fleminger J, Brockbank A, Graham D, Bramham K, Chappell LC, Delles C. Mary S, et al. J Nephrol. 2024 Apr;37(3):597-610. doi: 10.1007/s40620-023-01830-6. Epub 2024 Jan 18. J Nephrol. 2024. PMID: 38236469 Free PMC article.
Here we study the role of urinary uromodulin excretion in hypertensive pregnancy. METHODS: Urinary uromodulin was measured by ELISA in 146 pregnant women with treated chronic hypertension (n = 118) and controls (n = 28). ...During pregnancy, the uri …
Here we study the role of urinary uromodulin excretion in hypertensive pregnancy. METHODS: Urinary uromodulin wa …
Decreased preoperative urinary uromodulin as a predictor of acute kidney injury and perioperative kidney dysfunction in patients undergoing cardiac surgery: A prospective cohort study.
Zhang H, Lang H, Ma M, Yu M, Chai H, Hu Y, Chen W, Chen X. Zhang H, et al. Clin Chim Acta. 2022 May 1;530:1-7. doi: 10.1016/j.cca.2022.02.008. Epub 2022 Feb 15. Clin Chim Acta. 2022. PMID: 35176269
BACKGROUND: Acute kidney injury (AKI) is a major complication following cardiac surgery that substantially increases mortality. We explored the clinical utility of urinary uromodulin (uUMOD), a marker of renal tubular reserve, for preoperative identification …
BACKGROUND: Acute kidney injury (AKI) is a major complication following cardiac surgery that substantially increases mortality. We explored …
Kidney Damage Biomarkers and Incident Chronic Kidney Disease During Blood Pressure Reduction: A Case-Control Study.
Zhang WR, Craven TE, Malhotra R, Cheung AK, Chonchol M, Drawz P, Sarnak MJ, Parikh CR, Shlipak MG, Ix JH; SPRINT Research Group. Zhang WR, et al. Ann Intern Med. 2018 Nov 6;169(9):610-618. doi: 10.7326/M18-1037. Epub 2018 Oct 23. Ann Intern Med. 2018. PMID: 30357395 Free PMC article. Clinical Trial.
Compared with case participants in the standard group, those in the intensive group had significantly greater decreases in ACR, beta2-microglobulin, alpha1-microglobulin, YKL-40, and uromodulin. ...CONCLUSION: Incident CKD in the setting of intensive SBP lowering wa …
Compared with case participants in the standard group, those in the intensive group had significantly greater decreases in ACR, beta2 …
Lime powder treatment reduces urinary excretion of total protein and transferrin but increases uromodulin excretion in patients with urolithiasis.
Tosukhowong P, Kulpradit P, Chaiyarit S, Ungjareonwattana W, Kalpongnukul N, Ratchanon S, Thongboonkerd V. Tosukhowong P, et al. Urolithiasis. 2018 Jun;46(3):257-264. doi: 10.1007/s00240-017-0986-x. Epub 2017 Jun 5. Urolithiasis. 2018. PMID: 28585182 Clinical Trial.
Total urinary protein excretion was significantly decreased by LP treatment, but unaffected by placebo. ...Among these, the decrease of transferrin and increase of uromodulin were validated by ELISA. ...
Total urinary protein excretion was significantly decreased by LP treatment, but unaffected by placebo. ...Among these, the …
Apoptosis induced by an uromodulin mutant C112Y and its suppression by topiroxostat.
Utami SB, Mahati E, Li P, Maharani N, Ikeda N, Bahrudin U, Munemura C, Hosoyamada M, Yamamoto Y, Yoshida A, Nakayama Y, Higaki K, Nanba E, Ninomiya H, Shirayoshi Y, Ichida K, Yamamoto K, Hosoya T, Hisatome I. Utami SB, et al. Clin Exp Nephrol. 2015 Aug;19(4):576-84. doi: 10.1007/s10157-014-1032-8. Epub 2014 Sep 20. Clin Exp Nephrol. 2015. PMID: 25239792
BACKGROUND: Familial juvenile hyperuricemic nephropathy (FJHN) is an autosomal dominant disorder caused by mutations in UMOD that encodes uromodulin. Topiroxostat, a novel non-purine analog, selectively inhibits xanthine oxidase and reduces the serum uric acid levels …
BACKGROUND: Familial juvenile hyperuricemic nephropathy (FJHN) is an autosomal dominant disorder caused by mutations in UMOD that encodes …
Clinical Risk Factors For Kidney Tubule Biomarker Abnormalities Among Hypertensive Adults With Reduced eGFR in the SPRINT Trial.
Ikeme JC, Katz R, Muiru AN, Estrella MM, Scherzer R, Garimella PS, Hallan SI, Peralta CA, Ix JH, Shlipak MG. Ikeme JC, et al. Am J Hypertens. 2022 Dec 8;35(12):1006-1013. doi: 10.1093/ajh/hpac102. Am J Hypertens. 2022. PMID: 36094158 Free PMC article.
Men had 31% higher levels of alpha-1 microglobulin and 16% higher levels of beta-2 microglobulin, reflecting worse tubule resorptive function. Black race was associated with significantly higher levels of neutrophil gelatinase-associated lipocalin (12%) and l …
Men had 31% higher levels of alpha-1 microglobulin and 16% higher levels of beta-2 microglobulin, reflecting worse tubule reso …
Which urinary proteins are decreased after angiotensin converting--enzyme inhibition?
Guidi E, Giglioni A, Cozzi MG, Minetti EE. Guidi E, et al. Ren Fail. 1998 Mar;20(2):243-8. doi: 10.3109/08860229809045108. Ren Fail. 1998. PMID: 9574449
After 2 months of ACE inhibition, blood pressure (BP), body weight, urinary output, heart rate, plasma glucose, plasma and urinary creatinine, urate and electrolytes, and creatinine clearance, were not different from baseline values. ...Both albumin and THP urina …
After 2 months of ACE inhibition, blood pressure (BP), body weight, urinary output, heart rate, plasma glucose, plasma and urinary …
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