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Deoxygedunin, a natural product with potent neurotrophic activity in mice.
Jang SW, Liu X, Chan CB, France SA, Sayeed I, Tang W, Lin X, Xiao G, Andero R, Chang Q, Ressler KJ, Ye K. Jang SW, et al. PLoS One. 2010 Jul 13;5(7):e11528. doi: 10.1371/journal.pone.0011528. PLoS One. 2010. PMID: 20644624 Free PMC article.
Deoxygedunin is orally available and activates TrkB in mouse brain in a BDNF-independent way. ...Hence, deoxygedunin imitates BDNF's biological activities through activating TrkB, providing a powerful therapeutic tool for treatment of various neurological diseases.. …
Deoxygedunin is orally available and activates TrkB in mouse brain in a BDNF-independent way. ...Hence, deoxygedunin imitates …
Small molecule TrkB agonist deoxygedunin protects nigrostriatal dopaminergic neurons from 6-OHDA and MPTP induced neurotoxicity in rodents.
Nie S, Xu Y, Chen G, Ma K, Han C, Guo Z, Zhang Z, Ye K, Cao X. Nie S, et al. Neuropharmacology. 2015 Dec;99:448-58. doi: 10.1016/j.neuropharm.2015.08.016. Epub 2015 Aug 14. Neuropharmacology. 2015. PMID: 26282118
Mice were given deoxygedunin 5 mg/kg (i.p.) for 2 weeks and administrated with MPTP twice at the dose of 20 mg/kg (i.p.) on day 7. ...Thus, our current study indicates that deoxygedunin, as a small molecule TrkB agonist, displays prominent neuroprotective properties …
Mice were given deoxygedunin 5 mg/kg (i.p.) for 2 weeks and administrated with MPTP twice at the dose of 20 mg/kg (i.p.) on day 7. .. …
[Effects of deoxygedunin on Alzheimer-like pathologic dysfunction induced by D-galactose combined with AlCl(3)].
Chen JG, Jiang QC, Wen B, Wang RY, Wu YG, Li X. Chen JG, et al. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2018 Jun 8;34(6):496-500. doi: 10.12047/j.cjap.5732.2018.111. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2018. PMID: 31032583 Free article. Chinese.
OBJECTIVE: To investigate the effects of Deoxygedunin on Abeta deposition, learning memory, and oxidative stress induced by D-galactose combined with AlCl(3) in model rats with Alzheimer's disease and its possible mechanism. ...CONCLUSIONS: Supplement of Deoxygedunin …
OBJECTIVE: To investigate the effects of Deoxygedunin on Abeta deposition, learning memory, and oxidative stress induced by D-galacto …
TrkB agonists prevent postischemic emergence of refractory neonatal seizures in mice.
Kipnis PA, Sullivan BJ, Carter BM, Kadam SD. Kipnis PA, et al. JCI Insight. 2020 Jun 18;5(12):e136007. doi: 10.1172/jci.insight.136007. JCI Insight. 2020. PMID: 32427585 Free PMC article.
Here, the antiseizure efficacy of TrkB agonists LM22A-4, HIOC, and deoxygedunin (DG) on PB-refractory seizures and postischemic TrkB pathway activation was investigated in a mouse model (CD-1, P7) of refractory neonatal seizures. ...
Here, the antiseizure efficacy of TrkB agonists LM22A-4, HIOC, and deoxygedunin (DG) on PB-refractory seizures and postischemic TrkB …
Small-molecule trkB agonists promote axon regeneration in cut peripheral nerves.
English AW, Liu K, Nicolini JM, Mulligan AM, Ye K. English AW, et al. Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16217-22. doi: 10.1073/pnas.1303646110. Epub 2013 Sep 16. Proc Natl Acad Sci U S A. 2013. PMID: 24043773 Free PMC article.
In mice in which the neurotrophin receptor trkB is knocked out selectively in neurons, axon regeneration is very weak, and topical treatment with 7,8 DHF had no effect on axon regeneration. Similar treatments with deoxygedunin had only a modest effect. In conditional BDNF …
In mice in which the neurotrophin receptor trkB is knocked out selectively in neurons, axon regeneration is very weak, and topical treatment …
Carapa guianensis Aublet (Andiroba) Seed Oil: Chemical Composition and Antileishmanial Activity of Limonoid-Rich Fractions.
Oliveira IDSDS, Moragas Tellis CJ, Chagas MDSDS, Behrens MD, Calabrese KDS, Abreu-Silva AL, Almeida-Souza F. Oliveira IDSDS, et al. Biomed Res Int. 2018 Sep 6;2018:5032816. doi: 10.1155/2018/5032816. eCollection 2018. Biomed Res Int. 2018. PMID: 30258850 Free PMC article.
All the C. guianensis seed oil samples analyzed exhibited the same pattern of fatty acids, while the limonoids 7-deacetoxy-7-hydroxygedunin, deacetyldihydrogedunin, deoxygedunin, andirobin, gedunin, 11beta-hydroxygedunin, 17-glycolyldeoxygedunin, 6alpha-acetoxygedunin, and …
All the C. guianensis seed oil samples analyzed exhibited the same pattern of fatty acids, while the limonoids 7-deacetoxy-7-hydroxygedunin, …