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Page 1
Cytogenetic and molecular genetic evolution of chronic myeloid leukemia.
Johansson B, Fioretos T, Mitelman F. Johansson B, et al. Acta Haematol. 2002;107(2):76-94. doi: 10.1159/000046636. Acta Haematol. 2002. PMID: 11919388 Review.
Chronic myeloid leukemia (CML) is genetically characterized by the presence of the reciprocal translocation t(9;22)(q34;q11), resulting in a BCR/ABL gene fusion on the derivative chromosome 22 called the Philadelphia (Ph) chromosome. In 2-10% of the cases, this chim …
Chronic myeloid leukemia (CML) is genetically characterized by the presence of the reciprocal translocation t(9;22)(q34;q11), resulting in a …
Complex karyotype with double Philadelphia chromosome and T315I mutation results in blastic phase and extensive extramedullary infiltration in a chronic myeloid leukemia patient.
Davulcu EA, Pekerbas M, Karaca E, Durmaz B, Özsan N, Akın H, Saydam G. Davulcu EA, et al. Cancer Genet. 2022 Aug;266-267:74-80. doi: 10.1016/j.cancergen.2022.07.002. Epub 2022 Jul 6. Cancer Genet. 2022. PMID: 35843036
Chromosomal abnormalities can be seen in almost all cases, the most known anomaly being Philadelphia (Ph) chromosome, a derivative chromosome resulting from a translocation between 9. and 22. chromosome. ...Although these findings are not very rare individually, coe …
Chromosomal abnormalities can be seen in almost all cases, the most known anomaly being Philadelphia (Ph) chromosome, a derivative …
Induction of chromosome-specific micronuclei and chromothripsis by centromere inactivation.
Lin YF, Hu Q, Guyer A, Fachinetti D, Ly P. Lin YF, et al. Methods Cell Biol. 2024;182:1-20. doi: 10.1016/bs.mcb.2022.10.009. Epub 2022 Nov 28. Methods Cell Biol. 2024. PMID: 38359973
Chromothripsis describes the catastrophic fragmentation of individual chromosomes followed by its haphazard reassembly into a derivative chromosome harboring complex rearrangements. This process can be initiated by mitotic cell division errors when one or more chrom …
Chromothripsis describes the catastrophic fragmentation of individual chromosomes followed by its haphazard reassembly into a derivative …
Deletions of the derivative chromosome 9 do not influence the response and the outcome of chronic myeloid leukemia in early chronic phase treated with imatinib mesylate: GIMEMA CML Working Party analysis.
Castagnetti F, Testoni N, Luatti S, Marzocchi G, Mancini M, Kerim S, Giugliano E, Albano F, Cuneo A, Abruzzese E, Martino B, Palandri F, Amabile M, Iacobucci I, Alimena G, Pane F, Martinelli G, Saglio G, Baccarani M, Rosti G. Castagnetti F, et al. J Clin Oncol. 2010 Jun 1;28(16):2748-54. doi: 10.1200/JCO.2009.26.7963. Epub 2010 May 3. J Clin Oncol. 2010. PMID: 20439635 Clinical Trial.
PURPOSE: Deletions of the derivative chromosome 9 [der(9)] have been associated with a poor prognosis in chronic myeloid leukemia (CML) across different treatment modalities. ...
PURPOSE: Deletions of the derivative chromosome 9 [der(9)] have been associated with a poor prognosis in chronic myeloid leuke …
Molecular cytogenetic study of derivative chromosome 9 deletion in chronic myeloid leukemia patients.
Bennour A, Ouahchi I, Ben Youssef Y, Zaier M, Laatiri MA, Harrabi I, Meddeb B, Elloumi M, Khelif A, Saad A, Sennana H. Bennour A, et al. Med Oncol. 2012 Jun;29(2):1151-60. doi: 10.1007/s12032-011-9918-8. Epub 2011 Apr 3. Med Oncol. 2012. PMID: 21461967
The aims of this study are to investigate the frequency of derivative chromosome 9 (der (9)) deletion in Tunisian patients with chronic myeloid leukemia (CML) and to assess the correlation between this deletion and the cytogenetic response for patients treated with …
The aims of this study are to investigate the frequency of derivative chromosome 9 (der (9)) deletion in Tunisian patients wit …
Imatinib improves but may not fully reverse the poor prognosis of patients with CML with derivative chromosome 9 deletions.
Huntly BJ, Guilhot F, Reid AG, Vassiliou G, Hennig E, Franke C, Byrne J, Brizard A, Niederwieser D, Freeman-Edward J, Cuthbert G, Bown N, Clark RE, Nacheva EP, Green AR, Deininger MW. Huntly BJ, et al. Blood. 2003 Sep 15;102(6):2205-12. doi: 10.1182/blood-2002-09-2763. Epub 2003 May 15. Blood. 2003. PMID: 12750153 Free article. Clinical Trial.
Deletions of the derivative chromosome 9 occur in a subset of patients with Philadelphia chromosome-positive chronic myeloid leukemia (CML) and are associated with a poor prognosis on standard drug therapy. ...
Deletions of the derivative chromosome 9 occur in a subset of patients with Philadelphia chromosome-positive chronic myeloid l …
Derivative 6 as an additional chromosomal abnormality along with t(15;17): A case report.
Dalvi RC, Mandava S, Pais AP, Kokate PP, Sinha N, Nath UK. Dalvi RC, et al. Indian J Cancer. 2022 Jul-Sep;59(3):419-421. doi: 10.4103/ijc.IJC_1066_20. Indian J Cancer. 2022. PMID: 36412315 Free article.
We report a rare finding of primary clone of t(15;17) followed by a sequential clonal evolution of additional derivative chromosome 6 formation by a two hit mechanism. Our case showed a good clinical response with a four years and nine months event free survi …
We report a rare finding of primary clone of t(15;17) followed by a sequential clonal evolution of additional derivative chromosom …
Localisation and distance between ABL and BCR genes in interphase nuclei of bone marrow cells of control donors and patients with chronic myeloid leukaemia.
Lukásová E, Kozubek S, Kozubek M, Kjeronská J, Rýznar L, Horáková J, Krahulcová E, Horneck G. Lukásová E, et al. Hum Genet. 1997 Oct;100(5-6):525-35. doi: 10.1007/s004390050547. Hum Genet. 1997. PMID: 9341866
Quantitative measurements of the nuclear localisation of the ABL and BCR genes and the distance between them were performed in randomly oriented bone marrow cells of control donors and patients with chronic myeloid leukaemia (CML). Most ABL and BCR genes (75%) are located …
Quantitative measurements of the nuclear localisation of the ABL and BCR genes and the distance between them were performed in randomly …
Prognostic impact of deletions of derivative chromosome 9 in patients with chronic myelogenous leukemia treated with nilotinib or dasatinib.
Quintás-Cardama A, Kantarjian H, Shan J, Jabbour E, Abruzzo LV, Verstovsek S, Garcia-Manero G, O'Brien S, Cortes J. Quintás-Cardama A, et al. Cancer. 2011 Nov 15;117(22):5085-93. doi: 10.1002/cncr.26147. Epub 2011 Apr 26. Cancer. 2011. PMID: 21523765 Free PMC article. Clinical Trial.
RESULTS: Deletion of derivative chromosome 9 status was determined in 245 (69%). Twenty-eight (11%) patients, 22 in chronic phase, 4 in accelerated phase, and 2 in blast phase, carried deletions of derivative chromosome 9, including 17 receiving niloti …
RESULTS: Deletion of derivative chromosome 9 status was determined in 245 (69%). Twenty-eight (11%) patients, 22 in chronic ph …
A model for random genetic damage directing selection of diploid or aneuploid tumours.
Bazeley PS, Nestor Kalinoski AL, Ways JA, Liu ST, Ramdath RS, Matsui SI, Allison DC. Bazeley PS, et al. Cell Prolif. 2011 Jun;44(3):212-23. doi: 10.1111/j.1365-2184.2011.00746.x. Cell Prolif. 2011. PMID: 21535262 Free PMC article.
Specific loss of heterozygosis (LOHs), chromosomal abnormalities (called derivative chromosomes) and numbers of normal homologues were identified by SNP and SKY analyses. Random gene losses were calculated under the assumption that bi-allelic MMR gene inactivation causes a …
Specific loss of heterozygosis (LOHs), chromosomal abnormalities (called derivative chromosomes) and numbers of normal homologues were ident …
44 results