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Page 1
Pharmacology of N-desmethylclozapine.
Lameh J, Burstein ES, Taylor E, Weiner DM, Vanover KE, Bonhaus DW. Lameh J, et al. Pharmacol Ther. 2007 Aug;115(2):223-31. doi: 10.1016/j.pharmthera.2007.05.004. Epub 2007 May 21. Pharmacol Ther. 2007. PMID: 17583355 Review.
One intriguing possibility, based on clinical correlations, receptor activity profiles and studies with animal models predictive of antipsychotic or cognitive action is that the activity of N-desmethylclozapine (NDMC), a major metabolite of clozapine, may, at least in part …
One intriguing possibility, based on clinical correlations, receptor activity profiles and studies with animal models predictive of antipsyc …
N-desmethylclozapine: is there evidence for its antipsychotic potential?
Mendoza MC, Lindenmayer JP. Mendoza MC, et al. Clin Neuropharmacol. 2009 May-Jun;32(3):154-7. doi: 10.1097/WNF.0b013e31818d46f5. Clin Neuropharmacol. 2009. PMID: 19483482 Review.
OBJECTIVE: N-Desmethylclozapine (NDMC), one of clozapine's major metabolites, has become a recent focus of study for both its antipsychotic and metabolic effects. ...
OBJECTIVE: N-Desmethylclozapine (NDMC), one of clozapine's major metabolites, has become a recent focus of study for both its antipsy …
Relationship between plasma clozapine/N-desmethylclozapine and changes in basal forebrain-dorsolateral prefrontal cortex coupling in treatment-resistant schizophrenia.
Sarpal DK, Blazer A, Wilson JD, Calabro FJ, Foran W, Kahn CE, Luna B, Chengappa KNR. Sarpal DK, et al. Schizophr Res. 2022 May;243:170-177. doi: 10.1016/j.schres.2022.03.014. Epub 2022 Apr 2. Schizophr Res. 2022. PMID: 35381515 Free PMC article.
Previous work has linked the plasma ratio of CLZ and its major metabolite, N-desmethylclozapine (NDMC), to an inverse relationship with cognition via putative action on the cholinergic system. ...
Previous work has linked the plasma ratio of CLZ and its major metabolite, N-desmethylclozapine (NDMC), to an inverse relationship wi …
Distribution of clozapine and desmethylclozapine between blood and brain in rats.
Weigmann H, Härtter S, Fischer V, Dahmen N, Hiemke C. Weigmann H, et al. Eur Neuropsychopharmacol. 1999 Mar;9(3):253-6. doi: 10.1016/s0924-977x(98)00036-4. Eur Neuropsychopharmacol. 1999. PMID: 10208296
Desmethylclozapine concentrations exceeded those of clozapine at 2-5 h after drug application. In brain, drug concentrations were 15.8-fold higher for clozapine than in serum, but only 2.7-fold higher for desmethylclozapine. The brain clozapine concentrations exceed …
Desmethylclozapine concentrations exceeded those of clozapine at 2-5 h after drug application. In brain, drug concentrations were 15. …
N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl-D-aspartate receptor activity.
Sur C, Mallorga PJ, Wittmann M, Jacobson MA, Pascarella D, Williams JB, Brandish PE, Pettibone DJ, Scolnick EM, Conn PJ. Sur C, et al. Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13674-9. doi: 10.1073/pnas.1835612100. Epub 2003 Oct 31. Proc Natl Acad Sci U S A. 2003. PMID: 14595031 Free PMC article.
The interaction of clozapine with many G protein-coupled receptors is well documented but less is known about its biologically active metabolite, N-desmethylclozapine. Recent clinical and preclinical evidences of the antipsychotic activity of the muscarinic agonist xanomel …
The interaction of clozapine with many G protein-coupled receptors is well documented but less is known about its biologically active metabo …
N-desmethylclozapine: a clozapine metabolite that suppresses haemopoiesis.
Gerson SL, Arce C, Meltzer HY. Gerson SL, et al. Br J Haematol. 1994 Mar;86(3):555-61. doi: 10.1111/j.1365-2141.1994.tb04786.x. Br J Haematol. 1994. PMID: 8043437
We evaluated potential toxic mechanisms of drug-induced agranulocytosis. Clozapine, the two major metabolites N-desmethylclozapine and N-oxide clozapine, and five other clozapine derivatives were screened for toxicity to normal haemopoietic precursors. ...Bone marrow from …
We evaluated potential toxic mechanisms of drug-induced agranulocytosis. Clozapine, the two major metabolites N-desmethylclozapine an …
N-desmethylclozapine, an insensitive marker of clozapine-induced agranulocytosis and granulocytopenia.
Combs MD, Perry PJ, Bever KA. Combs MD, et al. Pharmacotherapy. 1997 Nov-Dec;17(6):1300-4. Pharmacotherapy. 1997. PMID: 9399615 Clinical Trial.
No significant correlation between granulocyte counts and patient demographic variables of clozapine and N-desmethylclozapine steady-state plasma concentrations, clozapine:N-desmethylclozapine ratio, age, gender, clozapine dosage, smoking status, and race were found …
No significant correlation between granulocyte counts and patient demographic variables of clozapine and N-desmethylclozapine steady- …
Associations between plasma clozapine/N-desmethylclozapine ratio, insulin resistance and cognitive performance in patients with co-morbid obesity and ultra-treatment resistant schizophrenia.
Costa-Dookhan KA, Rajji TK, Tran VN, Bowden S, Mueller DJ, Remington GJ, Agarwal SM, Hahn MK. Costa-Dookhan KA, et al. Sci Rep. 2021 Jan 21;11(1):2004. doi: 10.1038/s41598-021-81493-0. Sci Rep. 2021. PMID: 33479273 Free PMC article.
Clozapine (CLZ), the sole antipsychotic with superior efficacy for ultra-treatment resistant schizophrenia (TRS), is limited by adverse effects, including metabolic dysregulation. Clozapine's main metabolite, N-desmethylclozapine (NDMC), has potent 5-HT2C antagonist proper …
Clozapine (CLZ), the sole antipsychotic with superior efficacy for ultra-treatment resistant schizophrenia (TRS), is limited by adverse effe …
N-Desmethylclozapine, Fluoxetine, and Salmeterol Inhibit Postentry Stages of the Dengue Virus Life Cycle.
Medigeshi GR, Kumar R, Dhamija E, Agrawal T, Kar M. Medigeshi GR, et al. Antimicrob Agents Chemother. 2016 Oct 21;60(11):6709-6718. doi: 10.1128/AAC.01367-16. Print 2016 Nov. Antimicrob Agents Chemother. 2016. PMID: 27572397 Free PMC article.
We took the approach of repositioning approved drugs for anti-dengue virus activity by screening a library of pharmacologically active compounds. We identified N-desmethylclozapine, fluoxetine hydrochloride, and salmeterol xinafoate as dengue virus inhibitors based on redu …
We took the approach of repositioning approved drugs for anti-dengue virus activity by screening a library of pharmacologically active compo …
239 results