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Quoted phrase not found in phrase index: "Developmental and epileptic encephalopathy, 58"
Page 1
Efficacy and Safety of Fenfluramine for the Treatment of Seizures Associated With Lennox-Gastaut Syndrome: A Randomized Clinical Trial.
Knupp KG, Scheffer IE, Ceulemans B, Sullivan JE, Nickels KC, Lagae L, Guerrini R, Zuberi SM, Nabbout R, Riney K, Shore S, Agarwal A, Lock M, Farfel GM, Galer BS, Gammaitoni AR, Davis R, Gil-Nagel A. Knupp KG, et al. JAMA Neurol. 2022 Jun 1;79(6):554-564. doi: 10.1001/jamaneurol.2022.0829. JAMA Neurol. 2022. PMID: 35499850 Free PMC article. Clinical Trial.
IMPORTANCE: New treatment options are needed for patients with Lennox-Gastaut syndrome (LGS), a profoundly impairing, treatment-resistant, developmental and epileptic encephalopathy. OBJECTIVE: To evaluate the efficacy and safety of fenfluramine in patients w …
IMPORTANCE: New treatment options are needed for patients with Lennox-Gastaut syndrome (LGS), a profoundly impairing, treatment-resistant, …
Prenatal valproate exposure and risk of autism spectrum disorders and childhood autism.
Christensen J, Grønborg TK, Sørensen MJ, Schendel D, Parner ET, Pedersen LH, Vestergaard M. Christensen J, et al. JAMA. 2013 Apr 24;309(16):1696-703. doi: 10.1001/jama.2013.2270. JAMA. 2013. PMID: 23613074 Free PMC article.
IMPORTANCE: Valproate is used for the treatment of epilepsy and other neuropsychological disorders and may be the only treatment option for women of childbearing potential. ...The estimated absolute risk after 14 years of follow-up was 1.53% (95% CI, 1.47%-1.58%) fo …
IMPORTANCE: Valproate is used for the treatment of epilepsy and other neuropsychological disorders and may be the only treatment opti …
Pharmacotherapy for Dravet Syndrome: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials.
Lattanzi S, Trinka E, Russo E, Del Giovane C, Matricardi S, Meletti S, Striano P, Damavandi PT, Silvestrini M, Brigo F. Lattanzi S, et al. Drugs. 2023 Oct;83(15):1409-1424. doi: 10.1007/s40265-023-01936-y. Epub 2023 Sep 11. Drugs. 2023. PMID: 37695433 Free PMC article.
BACKGROUND: Dravet syndrome (DS) is a severe developmental and epileptic encephalopathy characterized by drug-resistant, lifelong seizures. ...Any randomized, controlled, double- or single-blinded, parallel-group study comparing at least one ASM therap …
BACKGROUND: Dravet syndrome (DS) is a severe developmental and epileptic encephalopathy characterized by drug-resistant …
Classic ketogenic diet versus further antiseizure medicine in infants with drug-resistant epilepsy (KIWE): a UK, multicentre, open-label, randomised clinical trial.
Schoeler NE, Marston L, Lyons L, Halsall S, Jain R, Titre-Johnson S, Balogun M, Heales SJR, Eaton S, Orford M, Neal E, Reilly C, Eltze C, Stephen E, Mallick AA, O'Callaghan F, Agrawal S, Parker A, Kirkpatrick M, Brunklaus A, McLellan A, McCullagh H, Samanta R, Kneen R, Tan HJ, Devlin A, Prasad M, Rattihalli R, Basu H, Desurkar A, Williams R, Fallon P, Nazareth I, Freemantle N, Cross JH; KIWE study group. Schoeler NE, et al. Lancet Neurol. 2023 Dec;22(12):1113-1124. doi: 10.1016/S1474-4422(23)00370-8. Lancet Neurol. 2023. PMID: 37977712 Free article. Clinical Trial.
We aimed to establish the efficacy of a classic ketogenic diet at reducing seizure frequency compared with further antiseizure medicine in infants with drug-resistant epilepsy. METHODS: In this phase 4, open-label, multicentre, randomised clinical trial …
We aimed to establish the efficacy of a classic ketogenic diet at reducing seizure frequency compared with further antiseizure medicine in i …
Long-term intellectual and developmental outcomes after pediatric epilepsy surgery: A systematic review and meta-analysis.
Stefanos-Yakoub I, Wingeier K, Held U, Latal B, Wirrell E, Smith ML, Ramantani G. Stefanos-Yakoub I, et al. Epilepsia. 2024 Feb;65(2):251-265. doi: 10.1111/epi.17834. Epub 2023 Dec 9. Epilepsia. 2024. PMID: 38031640 Review.
Although the efficacy of surgical treatment for seizure control has been established, the long-term intellectual and developmental trajectories are yet to be delineated. We conducted a systematic review and meta-analysis of studies reporting pre- and postsurgical intellige …
Although the efficacy of surgical treatment for seizure control has been established, the long-term intellectual and developmental tr …
Associations Between Maternal Antenatal Corticosteroid Treatment and Psychological Developmental and Neurosensory Disorders in Children.
Räikkönen K, Gissler M, Tapiainen T, Kajantie E. Räikkönen K, et al. JAMA Netw Open. 2022 Aug 1;5(8):e2228518. doi: 10.1001/jamanetworkopen.2022.28518. JAMA Netw Open. 2022. PMID: 36001315 Free PMC article.
MAIN OUTCOMES AND MEASURES: Cox proportional hazards regression models were used to estimate the associations between antenatal corticosteroid treatment and physician-diagnosed specific developmental disorders of speech and language, scholastic skills, and motor function; …
MAIN OUTCOMES AND MEASURES: Cox proportional hazards regression models were used to estimate the associations between antenatal corticostero …
Efficacy of perampanel in pediatric epilepsy with known and presumed genetic etiology.
Miao P, Zhu X, Jin W, Yu L, Li Y, Wang Y, Su Q, Xu S, Wang S, Feng J. Miao P, et al. Ann Clin Transl Neurol. 2023 Aug;10(8):1374-1382. doi: 10.1002/acn3.51828. Epub 2023 Jun 16. Ann Clin Transl Neurol. 2023. PMID: 37329172 Free PMC article.
METHODS: We included pediatric patients with potential genetic epilepsy who received PER treatment and underwent whole-exome sequencing (WES) from January 2020 to September 2021. ...Pathogenic or likely pathogenic variants in 27 multiple genes were detected among 58 …
METHODS: We included pediatric patients with potential genetic epilepsy who received PER treatment and underwent whole-exome sequenci …
Epileptic spasms: A South African overview of aetiologies, interventions, and outcomes.
Raga SV, Essajee F, Solomons R, Van Toorn R, Wilmshurst JM. Raga SV, et al. Dev Med Child Neurol. 2023 Apr;65(4):526-533. doi: 10.1111/dmcn.15433. Epub 2022 Oct 13. Dev Med Child Neurol. 2023. PMID: 36229895 Free article.
A lead time to treatment (LTTT) of less than 1 month was more likely in the epileptic encephalopathy/developmental and epileptic encephalopathy (DEE) group: 58 out of 92 (63%), compared to 28 out of 76 (37%) of those with developmental …
A lead time to treatment (LTTT) of less than 1 month was more likely in the epileptic encephalopathy/developmental and …
Epilepsy surgery in early infancy: A retrospective, multicenter study.
Makridis KL, Klotz KA, Ramantani G, Becker LL, San Antonio-Arce V, Syrbe S, Wagner K, Shah MJ, Thomale UW, Tietze A, Elger CE, Borggraefe I, Kaindl AM. Makridis KL, et al. Epilepsia Open. 2023 Sep;8(3):1182-1189. doi: 10.1002/epi4.12791. Epub 2023 Jul 23. Epilepsia Open. 2023. PMID: 37458529 Free PMC article.
We performed a retrospective multicenter study of infants who underwent epilepsy surgery in the first 6 months of life. 15 infants underwent epilepsy surgery at a median age of 134 days (IQR: 58) at four centers. ...Anti-seizure medication could be reduced in …
We performed a retrospective multicenter study of infants who underwent epilepsy surgery in the first 6 months of life. 15 infants un …
Proper Therapy Selection Improves Epilepsy Outcomes in Patients With Multilobar Sturge-Weber Syndrome.
Sugano H, Iimura Y, Suzuki H, Mitsuhashi T, Ueda T, Nishioka K, Tamrakar S, Karagiozov K, Nakajima M. Sugano H, et al. Pediatr Neurol. 2023 Jun;143:6-12. doi: 10.1016/j.pediatrneurol.2023.02.011. Epub 2023 Feb 24. Pediatr Neurol. 2023. PMID: 36934517 Free article.
Cognition was maintained in MTG and improved in STG (P = 0.002). The seizure-free rates in MTG and STG were 58.6% and 85.7%, respectively. CONCLUSIONS: Appropriate therapeutic choices improved seizure outcomes. Although patients who required surgery had more severe epil …
Cognition was maintained in MTG and improved in STG (P = 0.002). The seizure-free rates in MTG and STG were 58.6% and 85.7%, respecti …
63 results