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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1976 3
1977 2
1979 1
1980 4
1981 1
1982 7
1983 7
1984 10
1985 15
1986 14
1987 52
1988 26
1989 53
1990 61
1991 66
1992 76
1993 67
1994 94
1995 109
1996 87
1997 82
1998 70
1999 76
2000 77
2001 77
2002 87
2003 114
2004 101
2005 114
2006 109
2007 111
2008 120
2009 126
2010 140
2011 182
2012 154
2013 174
2014 216
2015 214
2016 239
2017 256
2018 275
2019 313
2020 352
2021 379
2022 421
2023 416
2024 195

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5,206 results

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Page 1
Rethinking developmental toxicity testing: Evolution or revolution?
Scialli AR, Daston G, Chen C, Coder PS, Euling SY, Foreman J, Hoberman AM, Hui J, Knudsen T, Makris SL, Morford L, Piersma AH, Stanislaus D, Thompson KE. Scialli AR, et al. Birth Defects Res. 2018 Jun 1;110(10):840-850. doi: 10.1002/bdr2.1212. Epub 2018 Feb 12. Birth Defects Res. 2018. PMID: 29436169 Free PMC article.
BACKGROUND: Current developmental toxicity testing adheres largely to protocols suggested in 1966 involving the administration of test compound to pregnant laboratory animals. ...DISCUSSION: Opportunities exist for refining and then replacing current developmenta …
BACKGROUND: Current developmental toxicity testing adheres largely to protocols suggested in 1966 involving the administration …
Building a developmental toxicity ontology.
Baker N, Boobis A, Burgoon L, Carney E, Currie R, Fritsche E, Knudsen T, Laffont M, Piersma AH, Poole A, Schneider S, Daston G. Baker N, et al. Birth Defects Res. 2018 Apr 3;110(6):502-518. doi: 10.1002/bdr2.1189. Epub 2018 Jan 31. Birth Defects Res. 2018. PMID: 29383852 Review.
This report discussed the need for a systematic representation of knowledge about developmental toxicity (i.e., an ontology) and proposes a method to build one based on knowledge of developmental biology and mode of action/ adverse outcome pathways in development …
This report discussed the need for a systematic representation of knowledge about developmental toxicity (i.e., an ontology) a …
Developmental toxicity and programming alterations of multiple organs in offspring induced by medication during pregnancy.
Lu Z, Guo Y, Xu D, Xiao H, Dai Y, Liu K, Chen L, Wang H. Lu Z, et al. Acta Pharm Sin B. 2023 Feb;13(2):460-477. doi: 10.1016/j.apsb.2022.05.029. Epub 2022 Jun 3. Acta Pharm Sin B. 2023. PMID: 36873163 Free PMC article. Review.
Further studies have found that medication during pregnancy may also indirectly lead to multi-organ developmental programming, functional homeostasis changes, and susceptibility to related diseases in offspring by inducing fetal intrauterine exposure to too high or too low levels …
Further studies have found that medication during pregnancy may also indirectly lead to multi-organ developmental programming, functional ho …
Male-mediated developmental toxicity.
Anderson D, Schmid TE, Baumgartner A. Anderson D, et al. Asian J Androl. 2014 Jan-Feb;16(1):81-8. doi: 10.4103/1008-682X.122342. Asian J Androl. 2014. PMID: 24369136 Free PMC article. Review.
Male-mediated developmental toxicity has been of concern for many years. The public became aware of male-mediated developmental toxicity in the early 1990s when it was reported that men working at Sellafield might be causing leukemia in their children. …
Male-mediated developmental toxicity has been of concern for many years. The public became aware of male-mediated developme …
Where developmental toxicity meets explainable artificial intelligence: state-of-the-art and perspectives.
Vittoria Togo M, Mastrolorito F, Orfino A, Graps EA, Tondo AR, Altomare CD, Ciriaco F, Trisciuzzi D, Nicolotti O, Amoroso N. Vittoria Togo M, et al. Expert Opin Drug Metab Toxicol. 2023 Dec 23:1-17. doi: 10.1080/17425255.2023.2298827. Online ahead of print. Expert Opin Drug Metab Toxicol. 2023. PMID: 38141160 Review.
INTRODUCTION: The application of Artificial Intelligence (AI) to predictive toxicology is rapidly increasing, particularly aiming to develop non-testing methods that effectively address ethical concerns and reduce economic costs. In this context, Developmental Toxicity …
INTRODUCTION: The application of Artificial Intelligence (AI) to predictive toxicology is rapidly increasing, particularly aiming to develop …
Developmental and Neurotoxicity of Acrylamide to Zebrafish.
Park JS, Samanta P, Lee S, Lee J, Cho JW, Chun HS, Yoon S, Kim WK. Park JS, et al. Int J Mol Sci. 2021 Mar 29;22(7):3518. doi: 10.3390/ijms22073518. Int J Mol Sci. 2021. PMID: 33805345 Free PMC article.
Acrylamide is a commonly used industrial chemical that is known to be neurotoxic to mammals. However, its developmental toxicity is rarely assessed in mammalian models because of the cost and complexity involved. ...At 6 h post fertilization, zebrafish embryos were …
Acrylamide is a commonly used industrial chemical that is known to be neurotoxic to mammals. However, its developmental toxicity …
[Developmental Toxicity of Nanoparticles on the Brain].
Umezawa M, Onoda A, Takeda K. Umezawa M, et al. Yakugaku Zasshi. 2017;137(1):73-78. doi: 10.1248/yakushi.16-00214. Yakugaku Zasshi. 2017. PMID: 28049898 Free article. Review. Japanese.
Here we reviewed the developmental toxicity of nanoparticles on the brain, one of the most important organs in maintenance of mental health and high quality of life. ...This knowledge will contribute to the safer design of nanoparticles through the development of se …
Here we reviewed the developmental toxicity of nanoparticles on the brain, one of the most important organs in maintenance of …
Advanced human developmental toxicity and teratogenicity assessment using human organoid models.
Li M, Gong J, Gao L, Zou T, Kang J, Xu H. Li M, et al. Ecotoxicol Environ Saf. 2022 Apr 15;235:113429. doi: 10.1016/j.ecoenv.2022.113429. Epub 2022 Mar 21. Ecotoxicol Environ Saf. 2022. PMID: 35325609 Free article. Review.
Tremendous progress has been made in the field of toxicology leading to the advance of developmental toxicity assessment. Conventional animal models and in vitro two-dimensional models cannot accurately describe toxic effects and predict actual in vivo responses due …
Tremendous progress has been made in the field of toxicology leading to the advance of developmental toxicity assessment. Conv …
Reproductive and developmental toxicity of plant growth regulators in humans and animals.
Wang X, Hao W. Wang X, et al. Pestic Biochem Physiol. 2023 Nov;196:105640. doi: 10.1016/j.pestbp.2023.105640. Epub 2023 Oct 4. Pestic Biochem Physiol. 2023. PMID: 37945238 Review.
PGRs can affect the synthesis and secretion of sex hormones, destroy the structure and function of the reproductive system, and harm the growth and development of offspring, which may be related to germ cell cycle disorders, apoptosis and oxidative stress. This review summaries t …
PGRs can affect the synthesis and secretion of sex hormones, destroy the structure and function of the reproductive system, and harm the gro …
Developmental toxicity of engineered nanomaterials in rodents.
Ema M, Gamo M, Honda K. Ema M, et al. Toxicol Appl Pharmacol. 2016 May 15;299:47-52. doi: 10.1016/j.taap.2015.12.015. Epub 2015 Dec 22. Toxicol Appl Pharmacol. 2016. PMID: 26721308 Review.
We summarized significant effects reported in the literature on the developmental toxicity of engineered nanomaterials (ENMs) in rodents. ...Although currently available data has provided initial information on the potential developmental toxicity of E …
We summarized significant effects reported in the literature on the developmental toxicity of engineered nanomaterials (ENMs) …
5,206 results