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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1985 1
1987 2
1988 3
1989 4
1990 3
1991 4
1992 3
1993 3
1994 7
1995 5
1996 7
1997 8
1998 5
1999 7
2000 13
2001 5
2002 3
2003 6
2004 14
2005 13
2006 9
2007 13
2008 9
2009 11
2010 9
2011 17
2012 8
2013 16
2014 11
2015 11
2016 17
2017 14
2018 12
2019 12
2020 9
2021 17
2022 19
2023 20
2024 6

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129 results

Results by year

Filters applied: Meta-Analysis, Review, Systematic Review, in the last 10 years. Clear all
Page 1
Dextromethorphan/Bupropion: First Approval.
Keam SJ. Keam SJ. CNS Drugs. 2022 Nov;36(11):1229-1238. doi: 10.1007/s40263-022-00968-4. CNS Drugs. 2022. PMID: 36301443 Review.
An oral, fixed-dose combination of dextromethorphan hydrobromide [an uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist and sigma-1 receptor agonist] and the antidepressant bupropion hydrochloride (an aminoketone and CYP2D6 inhibitor that increases dextrometh …
An oral, fixed-dose combination of dextromethorphan hydrobromide [an uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist an …
Dextromethorphan.
[No authors listed] [No authors listed] 2022 Dec. Mother To Baby | Fact Sheets [Internet]. Brentwood (TN): Organization of Teratology Information Specialists (OTIS); 1994–. 2022 Dec. Mother To Baby | Fact Sheets [Internet]. Brentwood (TN): Organization of Teratology Information Specialists (OTIS); 1994–. PMID: 35951932 Free Books & Documents. Review.
This sheet is about exposure to dextromethorphan in pregnancy and while breastfeeding. This information should not take the place of medical care and advice from your healthcare provider....
This sheet is about exposure to dextromethorphan in pregnancy and while breastfeeding. This information should not take the place of …
Dextromethorphan.
[No authors listed] [No authors listed] 2023 Dec 15. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. 2023 Dec 15. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. PMID: 30000516 Free Books & Documents. Review.
The amounts of dextromethorphan and its active metabolite in breastmilk are very low and are not expected to affect the nursing infant. ...
The amounts of dextromethorphan and its active metabolite in breastmilk are very low and are not expected to affect the nursing infan …
Dextromethorphan-bupropion (Auvelity) for the Treatment of Major Depressive Disorder.
McCarthy B, Bunn H, Santalucia M, Wilmouth C, Muzyk A, Smith CM. McCarthy B, et al. Clin Psychopharmacol Neurosci. 2023 Nov 30;21(4):609-616. doi: 10.9758/cpn.23.1081. Epub 2023 Jul 17. Clin Psychopharmacol Neurosci. 2023. PMID: 37859435 Free PMC article. Review.
Dextromethorphan modulates glutamate signaling through uncompetitive antagonism of N-methyl-D-aspartate receptors and sigma-1 agonism, while bupropion increases the bioavailability of dextromethorphan by CYP2D6 inhibition. ...Changes in Montgomery-Asberg Depression …
Dextromethorphan modulates glutamate signaling through uncompetitive antagonism of N-methyl-D-aspartate receptors and sigma-1 agonism …
Dextromethorphan/Bupropion: A Novel Oral NMDA (N-methyl-d-aspartate) Receptor Antagonist with Multimodal Activity.
Stahl SM. Stahl SM. CNS Spectr. 2019 Oct;24(5):461-466. doi: 10.1017/S1092852919001470. CNS Spectr. 2019. PMID: 31566163 Review.
The recent approval of the NMDA (N-methyl-d-aspartate) antagonist esketamine given intranasally for treatment-resistant depression has reinforced the need for agents with rapid onset with alternate mechanisms of action. Dextromethorphan/bupropion, an investigational medici …
The recent approval of the NMDA (N-methyl-d-aspartate) antagonist esketamine given intranasally for treatment-resistant depression has reinf …
Classics in Chemical Neuroscience: Dextromethorphan (DXM).
McClure EW, Daniels RN. McClure EW, et al. ACS Chem Neurosci. 2023 Jun 21;14(12):2256-2270. doi: 10.1021/acschemneuro.3c00088. Epub 2023 Jun 8. ACS Chem Neurosci. 2023. PMID: 37290117 Review.
Dextromethorphan (DXM) was introduced in 1958 as the first non-opioid cough suppressant and is indicated for multiple psychiatric disorders. ...
Dextromethorphan (DXM) was introduced in 1958 as the first non-opioid cough suppressant and is indicated for multiple psychiatric dis …
Combinations of dextromethorphan for the treatment of mood disorders - a review of the evidence.
Parincu Z, Iosifescu DV. Parincu Z, et al. Expert Rev Neurother. 2023 Mar;23(3):205-212. doi: 10.1080/14737175.2023.2192402. Epub 2023 Mar 21. Expert Rev Neurother. 2023. PMID: 36943010 Review.
However, dextromethorphan studies in adults with TRD or with bipolar depression have shown mixed results. ...Additional studies analyzing the effects of dextromethorphan and bupropion for TRD and bipolar depression are needed....
However, dextromethorphan studies in adults with TRD or with bipolar depression have shown mixed results. ...Additional studies analy …
Antipsychotic Drugs Efficacy in Dextromethorphan-Induced Psychosis.
Zaremba M, Serafin P, Kleczkowska P. Zaremba M, et al. Biomedicines. 2023 Jan 3;11(1):123. doi: 10.3390/biomedicines11010123. Biomedicines. 2023. PMID: 36672631 Free PMC article. Review.
One of the medicines that recently gained much attention in terms of its psychotic potential is dextromethorphan (DXM). DXM, a widely used antitussive drug, is a commonly abused drug because of its euphoric, hallucinogenic, and dissociative properties. ...
One of the medicines that recently gained much attention in terms of its psychotic potential is dextromethorphan (DXM). DXM, a widely …
Efficacy of dextromethorphan for the treatment of depression: a systematic review of preclinical and clinical trials.
Majeed A, Xiong J, Teopiz KM, Ng J, Ho R, Rosenblat JD, Phan L, Cao B, McIntyre RS. Majeed A, et al. Expert Opin Emerg Drugs. 2021 Mar;26(1):63-74. doi: 10.1080/14728214.2021.1898588. Epub 2021 Mar 12. Expert Opin Emerg Drugs. 2021. PMID: 33682569
AREAS COVERED: The synthesis herein of preclinical and clinical studies indicates that dextromethorphan (DXM) is well tolerated and exhibits clinically significant antidepressant effects; DXM combined with bupropion has demonstrated replicated and relatively rapid onset ef …
AREAS COVERED: The synthesis herein of preclinical and clinical studies indicates that dextromethorphan (DXM) is well tolerated and e …
Dextromethorphan/quinidine: a review of its use in adults with pseudobulbar affect.
Yang LP, Deeks ED. Yang LP, et al. Drugs. 2015 Jan;75(1):83-90. doi: 10.1007/s40265-014-0328-z. Drugs. 2015. PMID: 25420446 Review.
Fixed-dose dextromethorphan/quinidine capsules (Nuedexta()) utilize quinidine to inhibit the metabolism of dextromethorphan, enabling high plasma dextromethorphan concentrations to be reached without using a larger dose of the drug. ...Dextromethorphan …
Fixed-dose dextromethorphan/quinidine capsules (Nuedexta()) utilize quinidine to inhibit the metabolism of dextromethorphan, e …
129 results