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Spinal Cord Diffuse Midline Gliomas With H3 K27m-Mutant: Clinicopathological Features and Prognosis.
Wang YZ, Zhang YW, Liu WH, Chai RC, Cao R, Wang B, An SY, Jiang WJ, Xu YL, Yang J, Jia WQ. Wang YZ, et al. Neurosurgery. 2021 Jul 15;89(2):300-307. doi: 10.1093/neuros/nyab174. Neurosurgery. 2021. PMID: 34015818
BACKGROUND: "Diffuse midline glioma, H3 K27M-mutant" (DMG) mainly arises within the pontine, thalamic, and spinal cord regions. ...Univariate and multivariate analyses showed that histological grade and presurgery McCormick Scale score …
BACKGROUND: "Diffuse midline glioma, H3 K27M-mutant" (DMG) mainly arises within the pontine, thala …
Characterization of gliomas: from morphology to molecules.
Ferris SP, Hofmann JW, Solomon DA, Perry A. Ferris SP, et al. Virchows Arch. 2017 Aug;471(2):257-269. doi: 10.1007/s00428-017-2181-4. Epub 2017 Jul 4. Virchows Arch. 2017. PMID: 28674742 Review.
The entities reviewed within include diffuse gliomas (astrocytoma, oligodendroglioma, glioblastoma), as well as circumscribed and low-grade gliomas (angiocentric glioma, pilocytic astrocytoma, subependymal giant cell astrocytoma, pleomorphic xanthoastrocytoma, pilomyxoid astrocyt …
The entities reviewed within include diffuse gliomas (astrocytoma, oligodendroglioma, glioblastoma), as well as circumscribed and low-grade …
Tectal Low-Grade Glioma with H3 K27M Mutation.
Sumi K, Shijo K, Igarashi T, Yamamuro S, Sasano M, Oshima H, Ishige T, Honma T, Yagasaki H, Yoshino A. Sumi K, et al. World Neurosurg. 2020 Sep;141:91-100. doi: 10.1016/j.wneu.2020.05.240. Epub 2020 Jun 4. World Neurosurg. 2020. PMID: 32505657
BACKGROUND: In the revised World Health Organization 2016 classification of central nervous system tumors, "diffuse midline glioma, H3 K27M-mutant" has been added as a new diagnostic entity. ...This case might be identified as "diffuse …
BACKGROUND: In the revised World Health Organization 2016 classification of central nervous system tumors, "diffuse midline …
Diffuse high-grade gliomas with H3 K27M mutations carry a dismal prognosis independent of tumor location.
Karremann M, Gielen GH, Hoffmann M, Wiese M, Colditz N, Warmuth-Metz M, Bison B, Claviez A, van Vuurden DG, von Bueren AO, Gessi M, Kühnle I, Hans VH, Benesch M, Sturm D, Kortmann RD, Waha A, Pietsch T, Kramm CM. Karremann M, et al. Neuro Oncol. 2018 Jan 10;20(1):123-131. doi: 10.1093/neuonc/nox149. Neuro Oncol. 2018. PMID: 29016894 Free PMC article.
BACKGROUND: The novel entity of "diffuse midline glioma, H3 K27M-mutant" has been defined in the 2016 revision of the World Health Organization (WHO) classification of tumors of the central nervous system (CNS). ...CONCLUSION: These resul …
BACKGROUND: The novel entity of "diffuse midline glioma, H3 K27M-mutant" has been defined in the 2 …
Histone H3F3A and HIST1H3B K27M mutations define two subgroups of diffuse intrinsic pontine gliomas with different prognosis and phenotypes.
Castel D, Philippe C, Calmon R, Le Dret L, Truffaux N, Boddaert N, Pagès M, Taylor KR, Saulnier P, Lacroix L, Mackay A, Jones C, Sainte-Rose C, Blauwblomme T, Andreiuolo F, Puget S, Grill J, Varlet P, Debily MA. Castel D, et al. Acta Neuropathol. 2015 Dec;130(6):815-27. doi: 10.1007/s00401-015-1478-0. Epub 2015 Sep 23. Acta Neuropathol. 2015. PMID: 26399631 Free PMC article.
Diffuse intrinsic pontine glioma (DIPG) is the most severe paediatric solid tumour, with no significant therapeutic progress made in the past 50 years. Recent studies suggest that diffuse midline glioma, H3-K27M mutant, may comprise more …
Diffuse intrinsic pontine glioma (DIPG) is the most severe paediatric solid tumour, with no significant therapeutic progress made in the pas …
Pulvinar Locus is Highly Relevant to Patients' Outcomes in Surgically Resected Thalamic Gliomas in Children.
Chiba K, Aihara Y, Masui K, Abe K, Komori T, Kawamata T. Chiba K, et al. World Neurosurg. 2020 Feb;134:e530-e539. doi: 10.1016/j.wneu.2019.10.116. Epub 2019 Nov 5. World Neurosurg. 2020. PMID: 31704359
Histopathology was determined (retrospectively in a subset) according to the World Health Organization classification 2016, including the newly established type of "diffuse midline glioma, H3 K27M-mutant." RESULTS: Three low-grade gliomas …
Histopathology was determined (retrospectively in a subset) according to the World Health Organization classification 2016, including the ne …
A Rare High-Grade Glioma with a Histone H3 K27M Mutation in the Hypothalamus of an Adult Patient.
He P, Chen W, Qiu XX, Xi YB, Guan H, Xia J. He P, et al. World Neurosurg. 2019 Aug;128:527-531. doi: 10.1016/j.wneu.2019.04.172. Epub 2019 Apr 29. World Neurosurg. 2019. PMID: 31048046
BACKGROUND: Diffuse midline glioma H3 K27M mutant is a new tumor entity described in the revised 2016 World Health Organization classification. It is most frequently observed in children and develops in midline structures, includin …
BACKGROUND: Diffuse midline glioma H3 K27M mutant is a new tumor entity described in the revised 2 …