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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1996 1
1998 1
2002 1
2003 1
2004 3
2005 1
2006 9
2007 2
2008 2
2010 1
2011 2
2012 1
2013 4
2014 3
2015 2
2016 5
2017 3
2018 6
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2023 2
2024 4

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67 results

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Page 1
Fluoropyrimidine-induced cardiotoxicity.
Depetris I, Marino D, Bonzano A, Cagnazzo C, Filippi R, Aglietta M, Leone F. Depetris I, et al. Crit Rev Oncol Hematol. 2018 Apr;124:1-10. doi: 10.1016/j.critrevonc.2018.02.002. Epub 2018 Feb 7. Crit Rev Oncol Hematol. 2018. PMID: 29548480 Review.
This review summarizes the current state of knowledge of FIC with special regard to proposed pathogenetic models (coronary vasospasm, endothelium and cardiomyocytes damage, toxic metabolites, dihydropyrimidine dehydrogenase deficiency); risk and predictive factors; efficac …
This review summarizes the current state of knowledge of FIC with special regard to proposed pathogenetic models (coronary vasospasm, endoth …
DPYD genotyping and predicting fluoropyrimidine toxicity: where do we stand?
Lešnjaković L, Ganoci L, Bilić I, Šimičević L, Mucalo I, Pleština S, Božina N. Lešnjaković L, et al. Pharmacogenomics. 2023 Jan;24(2):93-106. doi: 10.2217/pgs-2022-0135. Epub 2023 Jan 13. Pharmacogenomics. 2023. PMID: 36636997 Review.
Pharmacogenomic guidelines issued by several pharmacogenetic organizations worldwide recommend testing four DPD gene (DPYD) risk variants, but these can predict only a proportion of toxicity cases. New evidence on additional common DPYD polymorphisms, as well as identifica …
Pharmacogenomic guidelines issued by several pharmacogenetic organizations worldwide recommend testing four DPD gene (DPYD) risk variants, b …
Dihydropyrimidine dehydrogenase and the efficacy and toxicity of 5-fluorouracil.
van Kuilenburg AB. van Kuilenburg AB. Eur J Cancer. 2004 May;40(7):939-50. doi: 10.1016/j.ejca.2003.12.004. Eur J Cancer. 2004. PMID: 15093568 Review.
Dihydropyrimidine dehydrogenase (DPD) is the initial and rate-limiting enzyme in the catabolism of 5-fluorouracil (5-FU). Although the role of tumoral levels as a prognostic factor for clinical responsiviness has not been firmly established, there is ample evidence that a …
Dihydropyrimidine dehydrogenase (DPD) is the initial and rate-limiting enzyme in the catabolism of 5-fluorouracil (5-FU). Although the role …
Predicting Dihydropyrimidine Dehydrogenase Deficiency and Related 5-Fluorouracil Toxicity: Opportunities and Challenges of DPYD Exon Sequencing and the Role of Phenotyping Assays.
De Luca O, Salerno G, De Bernardini D, Torre MS, Simmaco M, Lionetto L, Gentile G, Borro M. De Luca O, et al. Int J Mol Sci. 2022 Nov 11;23(22):13923. doi: 10.3390/ijms232213923. Int J Mol Sci. 2022. PMID: 36430399 Free PMC article.
DPYD genotyping of four recommended polymorphisms is widely used to predict toxicity, yet their prediction power is limited. Increasing availability of next generation sequencing (NGS) will allow us to screen rare variants, predicting a larger fraction of DPD …
DPYD genotyping of four recommended polymorphisms is widely used to predict toxicity, yet their prediction power is limited. I …
How I treat stage II colon cancer patients.
Taieb J, Karoui M, Basile D. Taieb J, et al. ESMO Open. 2021 Aug;6(4):100184. doi: 10.1016/j.esmoop.2021.100184. Epub 2021 Jul 5. ESMO Open. 2021. PMID: 34237612 Free PMC article. Review.
Stage II colon cancer (CC) is probably one of the best prognosis gastrointestinal tumors seen in our consultations, but often takes a lot of time for physicians to determine appropriate treatment because of the limited benefit of adjuvant chemotherapy (CT) in these patient …
Stage II colon cancer (CC) is probably one of the best prognosis gastrointestinal tumors seen in our consultations, but often takes a …
The effect of dihydropyrimidine dehydrogenase deficiency on outcomes with fluorouracil.
Gardiner SJ, Begg EJ, Robinson BA. Gardiner SJ, et al. Adverse Drug React Toxicol Rev. 2002;21(1-2):1-16. doi: 10.1007/BF03256180. Adverse Drug React Toxicol Rev. 2002. PMID: 12140902 Review.
The recognition that DPD deficiency increases toxicity has lead to the suggestion that genotypic or phenotypic assessment of DPD status prior to initiating fluorouracil may help predict outcomes. The gene that encodes for DPD expression is called DPYD. ...
The recognition that DPD deficiency increases toxicity has lead to the suggestion that genotypic or phenotypic assessment of DPD status prio …
Issues and limitations of available biomarkers for fluoropyrimidine-based chemotherapy toxicity, a narrative review of the literature.
Hodroj K, Barthelemy D, Lega JC, Grenet G, Gagnieu MC, Walter T, Guitton J, Payen-Gay L. Hodroj K, et al. ESMO Open. 2021 Jun;6(3):100125. doi: 10.1016/j.esmoop.2021.100125. Epub 2021 Apr 23. ESMO Open. 2021. PMID: 33895696 Free PMC article. Review.
Since April 2020, the European Medicines Agency (EMA) recommends DPD testing before any fluoropyrimidine-based treatment. Currently, different assays are used to predict DPD deficiency; the two main approaches consist of either phenotyping the enzyme activity (directly or …
Since April 2020, the European Medicines Agency (EMA) recommends DPD testing before any fluoropyrimidine-based treatment. Currently, differe …
Phenotypic and clinical implications of variants in the dihydropyrimidine dehydrogenase gene.
Kuilenburg ABPV, Meijer J, Tanck MWT, Dobritzsch D, Zoetekouw L, Dekkers LL, Roelofsen J, Meinsma R, Wymenga M, Kulik W, Büchel B, Hennekam RCM, Largiadèr CR. Kuilenburg ABPV, et al. Biochim Biophys Acta. 2016 Apr;1862(4):754-762. doi: 10.1016/j.bbadis.2016.01.009. Epub 2016 Jan 12. Biochim Biophys Acta. 2016. PMID: 26804652 Free article.
Genetic variations in the gene encoding DPD (DPYD) have emerged as predictive risk alleles for 5FU-associated toxicity. Here we report an in-depth analysis of genetic variants in DPYD and their consequences for DPD activity and pyrimidine metabolites in 100 Dutch healthy v …
Genetic variations in the gene encoding DPD (DPYD) have emerged as predictive risk alleles for 5FU-associated toxicity. Here we repor …
67 results