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Quoted phrase not found in phrase index: "Disorganization, mouse, homolog of"
Page 1
Aging stem cells. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging.
Zhang W, Li J, Suzuki K, Qu J, Wang P, Zhou J, Liu X, Ren R, Xu X, Ocampo A, Yuan T, Yang J, Li Y, Shi L, Guan D, Pan H, Duan S, Ding Z, Li M, Yi F, Bai R, Wang Y, Chen C, Yang F, Li X, Wang Z, Aizawa E, Goebl A, Soligalla RD, Reddy P, Esteban CR, Tang F, Liu GH, Belmonte JC. Zhang W, et al. Science. 2015 Jun 5;348(6239):1160-3. doi: 10.1126/science.aaa1356. Epub 2015 Apr 30. Science. 2015. PMID: 25931448 Free PMC article.
Moreover, decrease in WRN and heterochromatin marks are detected in MSCs from older individuals. Our observations uncover a role for WRN in maintaining heterochromatin stability and highlight heterochromatin disorganization as a potential determinant of human aging. …
Moreover, decrease in WRN and heterochromatin marks are detected in MSCs from older individuals. Our observations uncover a role for …
The Role of Indian Hedgehog Signaling in Tendon Response to Subacromial Impingement: Evaluation Using a Mouse Model.
Liu Y, Deng XH, Zhang X, Cong T, Chen D, Hall AJ, Ying L, Rodeo SA. Liu Y, et al. Am J Sports Med. 2022 Feb;50(2):362-370. doi: 10.1177/03635465211062244. Epub 2021 Dec 14. Am J Sports Med. 2022. PMID: 34904906
Thirteen mice without surgical intervention were utilized as the control group. ...Histological analysis demonstrated increased cellularity and disorganized collagen fibers in the SST, with higher modified Bonar scores at 4 weeks, followed by gradual improvem …
Thirteen mice without surgical intervention were utilized as the control group. ...Histological analysis demonstrated increased cellu …
Mutations in CKAP2L, the human homolog of the mouse Radmis gene, cause Filippi syndrome.
Hussain MS, Battaglia A, Szczepanski S, Kaygusuz E, Toliat MR, Sakakibara S, Altmüller J, Thiele H, Nürnberg G, Moosa S, Yigit G, Beleggia F, Tinschert S, Clayton-Smith J, Vasudevan P, Urquhart JE, Donnai D, Fryer A, Percin F, Brancati F, Dobbie A, Smigiel R, Gillessen-Kaesbach G, Wollnik B, Noegel AA, Newman WG, Nürnberg P. Hussain MS, et al. Am J Hum Genet. 2014 Nov 6;95(5):622-32. doi: 10.1016/j.ajhg.2014.10.008. Epub 2014 Nov 6. Am J Hum Genet. 2014. PMID: 25439729 Free PMC article.
In contrast to wild-type lymphoblastoid cell lines (LCLs), dividing LCLs established from the individuals homozygous for the c.571dupA mutation did not show CKAP2L at the spindle poles. Furthermore, in cells from the affected individuals, we observed an increase in the num …
In contrast to wild-type lymphoblastoid cell lines (LCLs), dividing LCLs established from the individuals homozygous for the c.571dupA mutat …
Evidence of a dosage effect and a physiological endplate acetylcholinesterase deficiency in the first mouse models mimicking Schwartz-Jampel syndrome neuromyotonia.
Stum M, Girard E, Bangratz M, Bernard V, Herbin M, Vignaud A, Ferry A, Davoine CS, Echaniz-Laguna A, René F, Marcel C, Molgó J, Fontaine B, Krejci E, Nicole S. Stum M, et al. Hum Mol Genet. 2008 Oct 15;17(20):3166-79. doi: 10.1093/hmg/ddn213. Epub 2008 Jul 21. Hum Mol Genet. 2008. PMID: 18647752
It has been suggested that SJS neuromyotonia may result from endplate acetylcholinesterase (AChE) deficiency, but this hypothesis has never been investigated in vivo due to the lack of an animal model for neuromyotonia. We used homologous recombination to generate a knock- …
It has been suggested that SJS neuromyotonia may result from endplate acetylcholinesterase (AChE) deficiency, but this hypothesis has never …
beta-Site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1)-deficient mice exhibit a close homolog of L1 (CHL1) loss-of-function phenotype involving axon guidance defects.
Hitt B, Riordan SM, Kukreja L, Eimer WA, Rajapaksha TW, Vassar R. Hitt B, et al. J Biol Chem. 2012 Nov 9;287(46):38408-25. doi: 10.1074/jbc.M112.415505. Epub 2012 Sep 17. J Biol Chem. 2012. PMID: 22988240 Free PMC article.
Recently, we have reported that BACE1 null mice have axon guidance defects in olfactory sensory neuron projections to glomeruli in the olfactory bulb. ...Remarkably, we discovered that the axon guidance defects of BACE1(-/-) mice were strikingly similar to those of …
Recently, we have reported that BACE1 null mice have axon guidance defects in olfactory sensory neuron projections to glomeruli in th …
Conditional deletion of pten leads to defects in nerve innervation and neuronal survival in inner ear development.
Kim HJ, Woo HM, Ryu J, Bok J, Kim JW, Choi SB, Park MH, Park HY, Koo SK. Kim HJ, et al. PLoS One. 2013;8(2):e55609. doi: 10.1371/journal.pone.0055609. Epub 2013 Feb 5. PLoS One. 2013. PMID: 23393595 Free PMC article.
Although Pten function has been studied in various systems, its role in inner ear development is poorly understood. Here, we used inner ear-specific Pten conditional knockout mice and examined the characteristics of the inner ear. In a detailed analysis of the phenotype, r …
Although Pten function has been studied in various systems, its role in inner ear development is poorly understood. Here, we used inner ear- …
Microtubule actin cross-linking factor (MACF): a hybrid of dystonin and dystrophin that can interact with the actin and microtubule cytoskeletons.
Leung CL, Sun D, Zheng M, Knowles DR, Liem RK. Leung CL, et al. J Cell Biol. 1999 Dec 13;147(6):1275-86. doi: 10.1083/jcb.147.6.1275. J Cell Biol. 1999. PMID: 10601340 Free PMC article.
We cloned and characterized a full-length cDNA of mouse actin cross-linking family 7 (mACF7) by sequential rapid amplification of cDNA ends-PCR. ...Hence, we suggest a modified name: MACF (microtubule actin cross-linking factor). The properties of MACF are consistent with …
We cloned and characterized a full-length cDNA of mouse actin cross-linking family 7 (mACF7) by sequential rapid amplification of cDN …
VEGF receptor-2-specific signaling mediated by VEGF-E induces hemangioma-like lesions in normal and in malignant tissue.
Fagiani E, Lorentz P, Bill R, Pavotbawan K, Kopfstein L, Christofori G. Fagiani E, et al. Angiogenesis. 2016 Jul;19(3):339-58. doi: 10.1007/s10456-016-9508-7. Epub 2016 Apr 1. Angiogenesis. 2016. PMID: 27038485
In addition, the formation of disorganized lymphatic vessels and increased immune cell infiltration is observed. ...These phenotypes markedly differ from the phenotypes observed with the transgenic expression of the other VEGF family members in beta-cells of …
In addition, the formation of disorganized lymphatic vessels and increased immune cell infiltration is observed. ...These phen …
Function of donor cell centrosome in intraspecies and interspecies nuclear transfer embryos.
Zhong ZS, Zhang G, Meng XQ, Zhang YL, Chen DY, Schatten H, Sun QY. Zhong ZS, et al. Exp Cell Res. 2005 May 15;306(1):35-46. doi: 10.1016/j.yexcr.2005.02.009. Epub 2005 Mar 17. Exp Cell Res. 2005. PMID: 15878330
In nuclear transfer (NT), MTOCs that are located at the poles of the meiotic spindle are removed from the recipient oocyte, while the centrosome of the donor cell is introduced. We used mouse MII oocytes as recipients, mouse fibroblasts, rat fibroblasts, or pig gran …
In nuclear transfer (NT), MTOCs that are located at the poles of the meiotic spindle are removed from the recipient oocyte, while the centro …
Targeted disruption of Col11a2 produces a mild cartilage phenotype in transgenic mice: comparison with the human disorder otospondylomegaepiphyseal dysplasia (OSMED).
Li SW, Takanosu M, Arita M, Bao Y, Ren ZX, Maier A, Prockop DJ, Mayne R. Li SW, et al. Dev Dyn. 2001 Oct;222(2):141-52. doi: 10.1002/dvdy.1178. Dev Dyn. 2001. PMID: 11668593 Free article.
Transgenic mice were prepared by homologous recombination with a Col11a2 targeting gene in which an inverted neomycin-resistant gene was inserted between restriction sites in exons 27 and 28. ...Expression of alpha1(X) specifically in the hypertrophic cartilage was …
Transgenic mice were prepared by homologous recombination with a Col11a2 targeting gene in which an inverted neomycin-resistan …
12 results