Ketamine's acute effects on negative brain states are mediated through distinct altered states of consciousness in humans.
Hack LM, Zhang X, Heifets BD, Suppes T, van Roessel PJ, Yesavage JA, Gray NJ, Hilton R, Bertrand C, Rodriguez CI, Deisseroth K, Knutson B, Williams LM.
Hack LM, et al.
Nat Commun. 2023 Oct 19;14(1):6631. doi: 10.1038/s41467-023-42141-5.
Nat Commun. 2023.
PMID: 37857620
Free PMC article.
Clinical Trial.
We used functional neuroimaging to engage key regions of the brain's affective circuits during acute ketamine-induced ASCs within a randomized, multi-modal, placebo-controlled design examining placebo, 0.05 mg/kg ketamine, and 0.5 mg/kg ketamine in nonclinical adult partic …
We used functional neuroimaging to engage key regions of the brain's affective circuits during acute ketamine-induced ASCs within a rando …