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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1977 1
1979 1
1983 1
1986 2
1989 2
1992 1
1994 1
1998 1
1999 3
2000 2
2001 2
2002 3
2003 3
2004 1
2005 4
2006 4
2007 6
2008 2
2009 6
2010 5
2011 5
2012 3
2013 4
2014 7
2015 4
2016 6
2017 9
2018 8
2019 8
2020 6
2021 12
2022 7
2023 9
2024 3

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126 results

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Page 1
Cardiovascular Calcification Heterogeneity in Chronic Kidney Disease.
Hutcheson JD, Goettsch C. Hutcheson JD, et al. Circ Res. 2023 Apr 14;132(8):993-1012. doi: 10.1161/CIRCRESAHA.123.321760. Epub 2023 Apr 13. Circ Res. 2023. PMID: 37053279 Free PMC article. Review.
Patients with chronic kidney disease (CKD) exhibit tremendously elevated risk for cardiovascular disease, particularly ischemic heart disease, due to premature vascular and cardiac aging and accelerated ectopic calcification. The presence of cardiovascular calcifica …
Patients with chronic kidney disease (CKD) exhibit tremendously elevated risk for cardiovascular disease, particularly ischemic heart diseas …
Histology and pathology of the human intervertebral disc.
Roberts S, Evans H, Trivedi J, Menage J. Roberts S, et al. J Bone Joint Surg Am. 2006 Apr;88 Suppl 2:10-4. doi: 10.2106/JBJS.F.00019. J Bone Joint Surg Am. 2006. PMID: 16595436 Review.
Discs from patients with spinal deformities such as scoliosis have ectopic calcification in the cartilage end plate and sometimes in the disc itself. ...
Discs from patients with spinal deformities such as scoliosis have ectopic calcification in the cartilage end plate and someti …
Alkaline Phosphatase: An Old Friend as Treatment Target for Cardiovascular and Mineral Bone Disorders in Chronic Kidney Disease.
Haarhaus M, Cianciolo G, Barbuto S, La Manna G, Gasperoni L, Tripepi G, Plebani M, Fusaro M, Magnusson P. Haarhaus M, et al. Nutrients. 2022 May 19;14(10):2124. doi: 10.3390/nu14102124. Nutrients. 2022. PMID: 35631265 Free PMC article. Review.
Beyond the well-known effects on bone mineralization, the bone ALP (BALP) isoforms (B/I, B1, B1x, and B2) are also involved in the pathogenesis of ectopic calcification. This narrative review summarizes the recent clinical investigations and mechanisms that link ALP …
Beyond the well-known effects on bone mineralization, the bone ALP (BALP) isoforms (B/I, B1, B1x, and B2) are also involved in the pathogene …
Biomolecules Orchestrating Cardiovascular Calcification.
Tintut Y, Honda HM, Demer LL. Tintut Y, et al. Biomolecules. 2021 Oct 7;11(10):1482. doi: 10.3390/biom11101482. Biomolecules. 2021. PMID: 34680115 Free PMC article. Review.
Since the initial discovery of bone morphogenetic protein in calcified human atherosclerotic lesions, decades of research have now led to the recognition that the regulatory mechanisms and the biomolecules that control cardiovascular calcification overlap with those controlling s …
Since the initial discovery of bone morphogenetic protein in calcified human atherosclerotic lesions, decades of research have now led to th …
Pathogenesis and management of vascular calcification in CKD and dialysis patients.
Kakani E, Elyamny M, Ayach T, El-Husseini A. Kakani E, et al. Semin Dial. 2019 Nov;32(6):553-561. doi: 10.1111/sdi.12840. Epub 2019 Aug 29. Semin Dial. 2019. PMID: 31464003 Review.
Patients with chronic kidney disease (CKD) have a predisposition to develop vascular calcification due to dysregulated homeostatic mechanisms, which lead to an imbalance in the circulatory promoters and inhibitors of vascular calcification, leading to a net calcification stress. …
Patients with chronic kidney disease (CKD) have a predisposition to develop vascular calcification due to dysregulated homeostatic mechanism …
Ectopic Calcification and Hypophosphatemic Rickets: Natural History of ENPP1 and ABCC6 Deficiencies.
Ferreira CR, Kintzinger K, Hackbarth ME, Botschen U, Nitschke Y, Mughal MZ, Baujat G, Schnabel D, Yuen E, Gahl WA, Gafni RI, Liu Q, Huertas P, Khursigara G, Rutsch F. Ferreira CR, et al. J Bone Miner Res. 2021 Nov;36(11):2193-2202. doi: 10.1002/jbmr.4418. Epub 2021 Aug 16. J Bone Miner Res. 2021. PMID: 34355424 Free PMC article.
Approximately 70% of these patients demonstrated evidence of ectopic calcification or complications similar to those seen in individuals with GACI, which shows that ARHR2 is not a distinct condition from GACI but represents part of the spectrum of ENPP1 deficiency. …
Approximately 70% of these patients demonstrated evidence of ectopic calcification or complications similar to those seen in i …
ABCC6 deficiency promotes dyslipidemia and atherosclerosis.
Brampton C, Pomozi V, Chen LH, Apana A, McCurdy S, Zoll J, Boisvert WA, Lambert G, Henrion D, Blanchard S, Kuo S, Leftheriotis G, Martin L, Le Saux O. Brampton C, et al. Sci Rep. 2021 Feb 16;11(1):3881. doi: 10.1038/s41598-021-82966-y. Sci Rep. 2021. PMID: 33594095 Free PMC article.
ABCC6 deficiency promotes ectopic calcification; however, circumstantial evidence suggested that ABCC6 may also influence atherosclerosis. ...
ABCC6 deficiency promotes ectopic calcification; however, circumstantial evidence suggested that ABCC6 may also influence athe …
Inherited Arterial Calcification Syndromes: Etiologies and Treatment Concepts.
Nitschke Y, Rutsch F. Nitschke Y, et al. Curr Osteoporos Rep. 2017 Aug;15(4):255-270. doi: 10.1007/s11914-017-0370-3. Curr Osteoporos Rep. 2017. PMID: 28585220 Review.
RECENT FINDINGS: Genetic studies of rare inherited syndromes have identified key regulators of ectopic calcification. Based on the pathogenic principles causing the diseases, these can be classified into three groups: (1) disorders of an increased extracellular inor …
RECENT FINDINGS: Genetic studies of rare inherited syndromes have identified key regulators of ectopic calcification. Based on …
Genetics of Diffuse Idiopathic Skeletal Hyperostosis and Ossification of the Spinal Ligaments.
Kato H, Braddock DT, Ito N. Kato H, et al. Curr Osteoporos Rep. 2023 Oct;21(5):552-566. doi: 10.1007/s11914-023-00814-6. Epub 2023 Aug 2. Curr Osteoporos Rep. 2023. PMID: 37530996 Free PMC article. Review.
Moreover, emerging evidence demonstrates that heterozygous and compound heterozygous ENPP1 pathogenic variants inducing 'Autosomal Recessive Hypophosphatemic Rickets Type 2' (ARHR2) also place patients at risk for DISH and OPLL, possibly due to the loss of inhibitory plasma pyrop …
Moreover, emerging evidence demonstrates that heterozygous and compound heterozygous ENPP1 pathogenic variants inducing 'Autosomal Recessive …
The fallacy of the calcium-phosphorus product.
O'Neill WC. O'Neill WC. Kidney Int. 2007 Oct;72(7):792-6. doi: 10.1038/sj.ki.5002412. Epub 2007 Jul 4. Kidney Int. 2007. PMID: 17609689 Free article. Review.
Experimental support is lacking, the chemistry underlying the use of the product is oversimplified and the concept that ectopic calcification is simply the result of supersaturation is biologically flawed. The evidence that the Ca x P is an independent risk factor f …
Experimental support is lacking, the chemistry underlying the use of the product is oversimplified and the concept that ectopic ca …
126 results