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Quoted phrase not found in phrase index: "Elevated urinary 3-hydroxybutyric acid"
Page 1
BDH1-mediated βOHB metabolism ameliorates diabetic kidney disease by activation of NRF2-mediated antioxidative pathway.
Wan SR, Teng FY, Fan W, Xu BT, Li XY, Tan XZ, Guo M, Gao CL, Zhang CX, Jiang ZZ, Xu Y. Wan SR, et al. Aging (Albany NY). 2023 Nov 27;15(22):13384-13410. doi: 10.18632/aging.205248. Epub 2023 Nov 27. Aging (Albany NY). 2023. PMID: 38015723 Free article.
We found that BDH1 is downregulated in the kidneys in DKD mouse models, patients with diabetes, and high glucose- or palmitic acid-induced human renal tubular epithelial (HK-2) cells. BDH1 overexpression or betaOHB treatment protects HK-2 cells from glucotoxicity and lipot …
We found that BDH1 is downregulated in the kidneys in DKD mouse models, patients with diabetes, and high glucose- or palmitic acid-in …
A Ketogenic Diet Reduces Central Obesity and Serum Insulin in Women with Ovarian or Endometrial Cancer.
Cohen CW, Fontaine KR, Arend RC, Alvarez RD, Leath CA III, Huh WK, Bevis KS, Kim KH, Straughn JM Jr, Gower BA. Cohen CW, et al. J Nutr. 2018 Aug 1;148(8):1253-1260. doi: 10.1093/jn/nxy119. J Nutr. 2018. PMID: 30137481 Free PMC article. Clinical Trial.
OBJECTIVE: We hypothesized that a KD would improve body composition and lower serum insulin and insulin-like growth factor-I (IGF-I) in women with ovarian or endometrial cancer. METHODS: In this randomized controlled trial, women with ovarian or endometrial cancer [ …
OBJECTIVE: We hypothesized that a KD would improve body composition and lower serum insulin and insulin-like growth factor-I (IGF-I) in wome …
The effect of ketone bodies and dietary carbohydrate intake on protein metabolism.
Sherwin RS. Sherwin RS. Acta Chir Scand Suppl. 1981;507:30-40. Acta Chir Scand Suppl. 1981. PMID: 6947662
In association with repeated 12 hr infusions of beta-hydroxybutyrate in subjects fasted 5-10 wks, urinary nitrogen fell by 30%, returning to baseline after cessation of the infusions and paralleling the changes in plasma alanine. ...Isocaloric replacement with carbohydrate …
In association with repeated 12 hr infusions of beta-hydroxybutyrate in subjects fasted 5-10 wks, urinary nitrogen fell by 30%, retur …
Carnitine and choline supplementation with exercise alter carnitine profiles, biochemical markers of fat metabolism and serum leptin concentration in healthy women.
Hongu N, Sachan DS. Hongu N, et al. J Nutr. 2003 Jan;133(1):84-9. doi: 10.1093/jn/133.1.84. J Nutr. 2003. PMID: 12514272 Clinical Trial.
We sought to determine the effects of supplementary choline, carnitine and a combination of the two with or without exercise on serum and urinary carnitine and biochemical markers of fatty acid oxidation in healthy humans. ...Serum beta-hydroxybutyrate and serum as …
We sought to determine the effects of supplementary choline, carnitine and a combination of the two with or without exercise on serum and …
β-Hydroxybutyrate Protects Against Cisplatin-Induced Renal Damage via Regulating Ferroptosis.
Tian R, Tang S, Zhao J, Hao Y, Zhao L, Han X, Wang X, Zhang L, Li R, Zhou X. Tian R, et al. Ren Fail. 2024 Dec;46(1):2354918. doi: 10.1080/0886022X.2024.2354918. Epub 2024 May 17. Ren Fail. 2024. PMID: 38757723 Free PMC article.
Exogenous or endogenous beta-HB effectively alleviated cisplatin-induced abnormally elevated levels of BUN and Cr and renal tubular necrosis in vivo. Additionally, beta-HB reduced ferroptosis biomarkers and increased the levels of anti-ferroptosis biomarkers in the kidney. …
Exogenous or endogenous beta-HB effectively alleviated cisplatin-induced abnormally elevated levels of BUN and Cr and renal tubular n …
beta-Hydroxybutyrate decreases adenosine triphosphate degradation products in human subjects.
Lestan B, Walden K, Schmaltz S, Spychala J, Fox IH. Lestan B, et al. J Lab Clin Med. 1994 Aug;124(2):199-209. J Lab Clin Med. 1994. PMID: 8051483 Clinical Trial.
Many disease states decrease intracellular adenosine triphosphate (ATP) levels and elevate body fluid purine levels. The use of specific metabolic substrates may reverse this process. ...During fructose-induced hepatic ATP breakdown, beta-hydroxybutyrate decreased late pha …
Many disease states decrease intracellular adenosine triphosphate (ATP) levels and elevate body fluid purine levels. The use of speci …
Association of increased hepatic insulin clearance and change in serum triglycerides or β-hydroxybutyrate concentration via the sodium/glucose-cotransporter 2 inhibitor tofogliflozin.
Matsubayashi Y, Yoshida A, Suganami H, Osawa T, Furukawa K, Suzuki H, Fujihara K, Tanaka S, Kaku K, Sone H. Matsubayashi Y, et al. Diabetes Obes Metab. 2020 Jun;22(6):947-956. doi: 10.1111/dom.13980. Epub 2020 Feb 14. Diabetes Obes Metab. 2020. PMID: 31984623 Free PMC article. Clinical Trial.
Sodium/glucose-cotransporter 2 inhibitors (SGLT2-is) improve insulin resistance and hyperinsulinaemia by weight loss via increased urinary glucose excretion in type 2 diabetes. However, there are few reports of the influence of SGLT2-is on hepatic insulin clearance. We exa …
Sodium/glucose-cotransporter 2 inhibitors (SGLT2-is) improve insulin resistance and hyperinsulinaemia by weight loss via increased urinar …
Episodic hypoglycemia with psi-hydroxy fatty acid excretion.
Colle E, Mamer OA, Montgomery JA, Miller JD. Colle E, et al. Pediatr Res. 1983 Feb;17(2):171-6. doi: 10.1203/00006450-198302000-00018. Pediatr Res. 1983. PMID: 6402754
We present case histories of two young children with episodes of hypoglycemia, elevation of SGOT, low insulin levels, increased urinary excretion of psi-hydroxy fatty acids (5-hydroxyhexanoic, 7-hydroxyoctanoic and 9-hydroxydecanoic), traces of the corresponding psi …
We present case histories of two young children with episodes of hypoglycemia, elevation of SGOT, low insulin levels, increased ur …
Possible synergistic effect of metformin and enalapril on the development of hyperkaliemic lactic acidosis.
Franzetti I, Paolo D, Marco G, Emanuela M, Elisabetta Z, Renato U. Franzetti I, et al. Diabetes Res Clin Pract. 1997 Dec;38(3):173-6. doi: 10.1016/s0168-8227(97)00098-3. Diabetes Res Clin Pract. 1997. PMID: 9483383
A 71 year old hypertensive, non insulin-dependent diabetic patient with moderate renal insufficiency taking 500 mg/d of metformin and 5 mg/d of enalapril, developed metabolic acidosis characterized by fairly elevated anion gap, hyperchloremia, severe hyperkaliemia, normal …
A 71 year old hypertensive, non insulin-dependent diabetic patient with moderate renal insufficiency taking 500 mg/d of metformin and 5 mg/d …