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Quoted phrase not found in phrase index: "Elevated urinary deoxyuridine level"
Page 1
Prognostic significance of thymidylate synthase activity in bladder carcinoma.
Mizutani Y, Wada H, Ogawa O, Yoshida O, Fukushima M, Nonomura N, Miki T. Mizutani Y, et al. Cancer. 2001 Aug 1;92(3):510-8. doi: 10.1002/1097-0142(20010801)92:3<510::aid-cncr1349>3.0.co;2-0. Cancer. 2001. PMID: 11505394
TS is the key enzyme in the catalysis of the methylation from deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate. Little is known about the significance of TS in bladder carcinoma. ...CONCLUSIONS: To the authors' knowledge, the current study is the first stu …
TS is the key enzyme in the catalysis of the methylation from deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate. Litt …
Clinical pharmacokinetic and pharmacodynamic studies with the nonclassical antifolate thymidylate synthase inhibitor 3, 4-dihydro-2-amino-6-methyl-4-oxo-5-(4-pyridylthio)-quinazolone dihydrochloride (AG337) given by 24-hour continuous intravenous infusion.
Rafi I, Taylor GA, Calvete JA, Boddy AV, Balmanno K, Bailey N, Lind M, Calvert AH, Webber S, Jackson RC, et al. Rafi I, et al. Clin Cancer Res. 1995 Nov;1(11):1275-84. Clin Cancer Res. 1995. PMID: 9815922 Clinical Trial.
Measurements of plasma deoxyuridine (dUrd) concentrations showed that doses of 600 mg/m2 and above of AG337 produced a consistent elevation in plasma dUrd levels (60-290%), suggesting that TS inhibition was being achieved in patients. ...These studies have shown tha …
Measurements of plasma deoxyuridine (dUrd) concentrations showed that doses of 600 mg/m2 and above of AG337 produced a consistent …