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Page 1
Multitarget μ-Opioid Receptor Agonists─Neuropeptide FF Receptor Antagonists Induce Potent Antinociception with Reduced Adverse Side Effects.
De Neve J, Elhabazi K, Gonzalez S, Herby C, Schneider S, Utard V, Fellmann-Clauss R, Petit-Demouliere N, Lecat S, Kremer M, Ces A, Daubeuf F, Martin C, Ballet S, Bihel F, Simonin F. De Neve J, et al. Among authors: elhabazi k. J Med Chem. 2024 May 9;67(9):7603-7619. doi: 10.1021/acs.jmedchem.4c00442. Epub 2024 Apr 30. J Med Chem. 2024. PMID: 38687204
Identification of an N-acylated-DArg-Leu-NH2 Dipeptide as a Highly Selective Neuropeptide FF1 Receptor Antagonist That Potently Prevents Opioid-Induced Hyperalgesia.
Quillet R, Schneider S, Utard V, Drieu la Rochelle A, Elhabazi K, Henningsen JB, Gizzi P, Schmitt M, Kugler V, Simonneaux V, Ilien B, Simonin F, Bihel F. Quillet R, et al. Among authors: elhabazi k. J Med Chem. 2021 Jun 10;64(11):7555-7564. doi: 10.1021/acs.jmedchem.1c00256. Epub 2021 May 19. J Med Chem. 2021. PMID: 34008968
RF313, an orally bioavailable neuropeptide FF receptor antagonist, opposes effects of RF-amide-related peptide-3 and opioid-induced hyperalgesia in rodents.
Elhabazi K, Humbert JP, Bertin I, Quillet R, Utard V, Schneider S, Schmitt M, Bourguignon JJ, Laboureyras E, Ben Boujema M, Simonnet G, Ancel C, Simonneaux V, Beltramo M, Bucher B, Sorg T, Meziane H, Schneider E, Petit-Demoulière B, Ilien B, Bihel F, Simonin F. Elhabazi K, et al. Neuropharmacology. 2017 May 15;118:188-198. doi: 10.1016/j.neuropharm.2017.03.012. Epub 2017 Mar 10. Neuropharmacology. 2017. PMID: 28288815
Lemon juice has protective activity in a rat urolithiasis model.
Touhami M, Laroubi A, Elhabazi K, Loubna F, Zrara I, Eljahiri Y, Oussama A, Grases F, Chait A. Touhami M, et al. Among authors: elhabazi k. BMC Urol. 2007 Oct 5;7:18. doi: 10.1186/1471-2490-7-18. BMC Urol. 2007. PMID: 17919315 Free PMC article.
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