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Page 1
Approach to the Patient: Diagnosis of Cushing Syndrome.
Savas M, Mehta S, Agrawal N, van Rossum EFC, Feelders RA. Savas M, et al. J Clin Endocrinol Metab. 2022 Nov 23;107(11):3162-3174. doi: 10.1210/clinem/dgac492. J Clin Endocrinol Metab. 2022. PMID: 36036941 Free PMC article.
First-line screening tests including the 1-mg dexamethasone suppression test, 24-hour urinary free cortisol excretion, and late-night salivary cortisol measurement should be performed to screen for endogenous Cushing syndrome. Scalp-hair cortisol/cortisone an …
First-line screening tests including the 1-mg dexamethasone suppression test, 24-hour urinary free cortisol excretion, and late-night saliva …
Paediatric Cushing syndrome: a prospective, multisite, observational cohort study.
Tatsi C, Kamilaris C, Keil M, Saidkhodjaeva L, Faucz FR, Chittiboina P, Stratakis CA. Tatsi C, et al. Lancet Child Adolesc Health. 2024 Jan;8(1):51-62. doi: 10.1016/S2352-4642(23)00264-X. Lancet Child Adolesc Health. 2024. PMID: 38097317
BACKGROUND: Paediatric endogenous Cushing syndrome is a rare condition with variable signs and symptoms of presentation. We studied a large cohort of paediatric patients with endogenous Cushing syndrome with the aim of describing anthropo …
BACKGROUND: Paediatric endogenous Cushing syndrome is a rare condition with variable signs and symptoms of presentation …
ARMC5-negative primary bilateral macronodular adrenal hyperplasia.
Sol B, Carprieaux M, De Leu N. Sol B, et al. BMJ Case Rep. 2023 Jul 6;16(7):e254099. doi: 10.1136/bcr-2022-254099. BMJ Case Rep. 2023. PMID: 37419498
Primary bilateral macronodular adrenal hyperplasia was confirmed by pathology after bilateral adrenalectomy. Gradual mental and physical recovery was observed in the months following surgery. Genetic sequencing failed to reveal mutations in the ARMC5 gene.Cushing syndrome …
Primary bilateral macronodular adrenal hyperplasia was confirmed by pathology after bilateral adrenalectomy. Gradual mental and physical rec …
Diurnal Plasma Cortisol Measurements Utility in Differentiating Various Etiologies of Endogenous Cushing Syndrome.
Tirosh A, Lodish MB, Papadakis GZ, Lyssikatos C, Belyavskaya E, Stratakis CA. Tirosh A, et al. Horm Metab Res. 2016 Sep;48(10):677-681. doi: 10.1055/s-0042-115644. Epub 2016 Sep 19. Horm Metab Res. 2016. PMID: 27643448 Free PMC article.
Cortisol diurnal variation may be abnormal among patients with endogenous Cushing syndrome (CS). The study objective was to compare the plasma cortisol AM/PM ratios between different etiologies of CS. ...An AM/PM cortisol ratio2.0 among patients with unsuppre …
Cortisol diurnal variation may be abnormal among patients with endogenous Cushing syndrome (CS). The study objective wa …
Relacorilant, a Selective Glucocorticoid Receptor Modulator, Induces Clinical Improvements in Patients With Cushing Syndrome: Results From A Prospective, Open-Label Phase 2 Study.
Pivonello R, Bancos I, Feelders RA, Kargi AY, Kerr JM, Gordon MB, Mariash CN, Terzolo M, Ellison N, Moraitis AG. Pivonello R, et al. Front Endocrinol (Lausanne). 2021 Jul 14;12:662865. doi: 10.3389/fendo.2021.662865. eCollection 2021. Front Endocrinol (Lausanne). 2021. PMID: 34335465 Free PMC article. Clinical Trial.
We evaluated the efficacy and safety of relacorilant in patients with endogenous Cushing syndrome (CS). MATERIALS AND METHODS: A single-arm, open-label, phase 2, dose-finding study with 2 dose groups (NCT02804750, https://clinicaltrials.gov/ct2/show/NCT028047 …
We evaluated the efficacy and safety of relacorilant in patients with endogenous Cushing syndrome (CS). MATERIALS AND M …
Carbohydrate and lipid metabolism in endogenous hypercortisolism: shared features with metabolic syndrome X and NIDDM.
Friedman TC, Mastorakos G, Newman TD, Mullen NM, Horton EG, Costello R, Papadopoulos NM, Chrousos GP. Friedman TC, et al. Endocr J. 1996 Dec;43(6):645-55. doi: 10.1507/endocrj.43.645. Endocr J. 1996. PMID: 9075604 Free article.
Carbohydrate and lipid metabolism was cross-sectionally assessed in 16 patients with endogenous hypercortisolism (endogenous Cushing syndrome). Five patients (31%) had fasting glucose levels over 6.6 mmol/l and a HbA1C over 7.5%. ...We conclude that impaired …
Carbohydrate and lipid metabolism was cross-sectionally assessed in 16 patients with endogenous hypercortisolism (endogenous Cushi …
Effects of child- and adolescent-onset endogenous Cushing syndrome on bone mass, body composition, and growth: a 7-year prospective study into young adulthood.
Leong GM, Abad V, Charmandari E, Reynolds JC, Hill S, Chrousos GP, Nieman LK. Leong GM, et al. J Bone Miner Res. 2007 Jan;22(1):110-8. doi: 10.1359/jbmr.061010. J Bone Miner Res. 2007. PMID: 17042737 Free article.
In 14 children followed for 3-7 years into young adulthood after cure of CS, whereas bone mass largely recovered, persisting increases in total body and visceral fat suggests an increase risk of the metabolic syndrome. INTRODUCTION: Endogenous Cushing syndrome …
In 14 children followed for 3-7 years into young adulthood after cure of CS, whereas bone mass largely recovered, persisting increases in to …
Diagnostic tests for children who are referred for the investigation of Cushing syndrome.
Batista DL, Riar J, Keil M, Stratakis CA. Batista DL, et al. Pediatrics. 2007 Sep;120(3):e575-86. doi: 10.1542/peds.2006-2402. Epub 2007 Aug 13. Pediatrics. 2007. PMID: 17698579
OBJECTIVE: Endogenous Cushing syndrome in children is a rare disorder that is most frequently caused by pituitary or adrenocortical tumors. ...
OBJECTIVE: Endogenous Cushing syndrome in children is a rare disorder that is most frequently caused by pituitary or ad …
Optical Imaging Technology: A Useful Tool to Identify Remission in Cushing Disease After Surgery.
Afshari A, Keil M, Lyssikatos C, Belyavskaya E, Valdés N, Chowdhry FA, Parsa K, Ardeshirpour Y, Pursley R, Khare S, Kainerstorfer JM, Chittiboina P, Lodish MB, Mazzuchi TA, Gandjbakhche AH, Stratakis CA. Afshari A, et al. Horm Metab Res. 2019 Feb;51(2):120-126. doi: 10.1055/a-0801-8917. Epub 2019 Jan 2. Horm Metab Res. 2019. PMID: 30602178 Free PMC article.
We recently reported the use of optical imaging technology to quantify facial plethora in endogenous Cushing syndrome (CS). In the present study, we studied a larger cohort of patients with Cushing disease (CD) and examined water content fraction as well as b …
We recently reported the use of optical imaging technology to quantify facial plethora in endogenous Cushing syndrome ( …
Children experience cognitive decline despite reversal of brain atrophy one year after resolution of Cushing syndrome.
Merke DP, Giedd JN, Keil MF, Mehlinger SL, Wiggs EA, Holzer S, Rawson E, Vaituzis AC, Stratakis CA, Chrousos GP. Merke DP, et al. J Clin Endocrinol Metab. 2005 May;90(5):2531-6. doi: 10.1210/jc.2004-2488. Epub 2005 Mar 1. J Clin Endocrinol Metab. 2005. PMID: 15741254
Eleven children (six girls, five boys; ages, 8-16 yr) with endogenous Cushing syndrome seen at the National Institutes of Health Clinical Center from 1999-2000 and 10 healthy age- and sex-matched control subjects were studied. ...Despite reversal of cerebral …
Eleven children (six girls, five boys; ages, 8-16 yr) with endogenous Cushing syndrome seen at the National Institutes …
13 results