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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1997 2
1998 2
1999 1
2001 1
2002 2
2003 2
2004 3
2006 3
2007 2
2008 2
2009 1
2010 3
2011 4
2012 1
2013 1
2014 3
2015 3
2016 4
2018 1
2019 3
2020 1
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2024 0

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44 results

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Page 1
Pharmacotherapy of cerebellar and vestibular disorders.
Lemos J, Manto M. Lemos J, et al. Curr Opin Neurol. 2022 Feb 1;35(1):118-125. doi: 10.1097/WCO.0000000000001015. Curr Opin Neurol. 2022. PMID: 34845147 Review.
In an open-label study, N-acetyl-l-leucine administered for 6-weeks significantly improved clinical impression of change, ataxia, and quality of life in patients with Niemann-Pick disease type C1. ...A gluten-free diet alone improved ataxia in half of patients with antiglu …
In an open-label study, N-acetyl-l-leucine administered for 6-weeks significantly improved clinical impression of change, ataxia, and …
Episodic ataxia type 2.
Strupp M, Zwergal A, Brandt T. Strupp M, et al. Neurotherapeutics. 2007 Apr;4(2):267-73. doi: 10.1016/j.nurt.2007.01.014. Neurotherapeutics. 2007. PMID: 17395137 Free article. Review.
Episodic ataxia type 2 (EA 2) is a rare neurological disorder of autosomal dominant inheritance resulting from dysfunction of a voltage-gated calcium channel. ...Many aspects of the pathophysiology (e.g., induction of the attacks) and treatment of EA 2 …
Episodic ataxia type 2 (EA 2) is a rare neurological disorder of autosomal dominant inheritance resulting from d …
Aminopyridines and Acetyl-DL-leucine: New Therapies in Cerebellar Disorders.
Kalla R, Strupp M. Kalla R, et al. Curr Neuropharmacol. 2019;17(1):7-13. doi: 10.2174/1570159X16666180905093535. Curr Neuropharmacol. 2019. PMID: 30182858 Free PMC article. Review.
Studies with animals have demonstrated, that a nonselective blockage of voltage-gated potassium channels (mainly Kv1.5) increases Purkinje- cell (PC) excitability. In episodic ataxia type 2 (EA2), which is frequently caused by mutations of the PQ-calci …
Studies with animals have demonstrated, that a nonselective blockage of voltage-gated potassium channels (mainly Kv1.5) increases Purkinje- …
Update on the Pharmacotherapy of Cerebellar Ataxia and Nystagmus.
Feil K, Bremova T, Muth C, Schniepp R, Teufel J, Strupp M. Feil K, et al. Cerebellum. 2016 Feb;15(1):38-42. doi: 10.1007/s12311-015-0733-1. Cerebellum. 2016. PMID: 26519380 Review.
The efficacy of most of the agents recommended in the past for symptomatic or even causative therapy could not be proven in larger state-of-the art clinical trials. Exceptions are (a) 4-aminopyridine (4-AP) for episodic ataxia type 2 (EA2): one …
The efficacy of most of the agents recommended in the past for symptomatic or even causative therapy could not be proven in larger state-of- …
Update on the pharmacotherapy of cerebellar and central vestibular disorders.
Kalla R, Teufel J, Feil K, Muth C, Strupp M. Kalla R, et al. J Neurol. 2016 Apr;263 Suppl 1:S24-9. doi: 10.1007/s00415-015-7987-x. Epub 2016 Apr 15. J Neurol. 2016. PMID: 27083881 Free PMC article. Review.
Animal studies showed that this non-selective blocker of voltage-gated potassium channels increases Purkinje cell excitability and normalizes the irregular firing rate, so that the inhibitory influence of the cerebellar cortex on vestibular and deep cerebellar nuclei is restored. …
Animal studies showed that this non-selective blocker of voltage-gated potassium channels increases Purkinje cell excitability and normalize …
Phenotypes, genotypes, and the management of paroxysmal movement disorders.
Silveira-Moriyama L, Kovac S, Kurian MA, Houlden H, Lees AJ, Walker MC, Roze E, Paciorkowski AR, Mink JW, Warner TT. Silveira-Moriyama L, et al. Dev Med Child Neurol. 2018 Jun;60(6):559-565. doi: 10.1111/dmcn.13744. Epub 2018 Mar 30. Dev Med Child Neurol. 2018. PMID: 29600549 Free article. Review.
Antiepileptic drugs remain the treatment of choice for PKD and episodic ataxia type 1, benzodiazepines are often useful for PNKD, and episodic ataxia type 2 benefits from acetazolamide regardless of the genetic etiology. WHAT THE PAPER ADDS: A growing …
Antiepileptic drugs remain the treatment of choice for PKD and episodic ataxia type 1, benzodiazepines are often useful for PNKD, and epi …
Pharmacotherapy of vestibular and cerebellar disorders and downbeat nystagmus: translational and back-translational research.
Strupp M, Zwergal A, Feil K, Bremova T, Brandt T. Strupp M, et al. Ann N Y Acad Sci. 2015 Apr;1343:27-36. doi: 10.1111/nyas.12774. Ann N Y Acad Sci. 2015. PMID: 25903394 Review.
In vestibular paroxysmia, oxcarbazepine was effective (one yet not randomized controlled trial (RCT)). Aminopyridines are recommended for the treatment of downbeat nystagmus (two RCTs) and episodic ataxia type 2 (EA2, one RCT). ...
In vestibular paroxysmia, oxcarbazepine was effective (one yet not randomized controlled trial (RCT)). Aminopyridines are reco …
Paroxysmal movement disorders - practical update on diagnosis and management.
De Gusmao CM, Silveira-Moriyama L. De Gusmao CM, et al. Expert Rev Neurother. 2019 Sep;19(9):807-822. doi: 10.1080/14737175.2019.1648211. Epub 2019 Aug 8. Expert Rev Neurother. 2019. PMID: 31353980 Review.
Despite the exponential increase in publications of genetically confirmed cases, management remains largely clinical based on non-systematic evidence. Areas covered: The authors provide a historical and clinical review of the main types of paroxysmal dyskinesias and …
Despite the exponential increase in publications of genetically confirmed cases, management remains largely clinical based on non-sys …
Medical treatment of vestibular disorders.
Brandt T, Zwergal A, Strupp M. Brandt T, et al. Expert Opin Pharmacother. 2009 Jul;10(10):1537-48. doi: 10.1517/14656560902976879. Expert Opin Pharmacother. 2009. PMID: 19527184 Review.
RESULTS/CONCLUSIONS: In vestibular neuritis, recovery of the peripheral vestibular function can be improved by oral corticosteroids; in Meniere's disease, there is first evidence that high-dose, long-term administration of betahistine reduces attack frequency; carbamazepine or ox …
RESULTS/CONCLUSIONS: In vestibular neuritis, recovery of the peripheral vestibular function can be improved by oral corticosteroids; in Meni …
Consensus paper: management of degenerative cerebellar disorders.
Ilg W, Bastian AJ, Boesch S, Burciu RG, Celnik P, Claaßen J, Feil K, Kalla R, Miyai I, Nachbauer W, Schöls L, Strupp M, Synofzik M, Teufel J, Timmann D. Ilg W, et al. Cerebellum. 2014 Apr;13(2):248-68. doi: 10.1007/s12311-013-0531-6. Cerebellum. 2014. PMID: 24222635 Free PMC article.
Aminopyridines and acetazolamide are the only exception, which are beneficial in patients with episodic ataxia type 2. Aminopyridines are also effective in a subset of patients presenting with downbeat nystagmus. ...
Aminopyridines and acetazolamide are the only exception, which are beneficial in patients with episodic ataxia type …
44 results