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1979 1
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1990 4
1991 1
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Page 1
Pharmacokinetic/pharmacodynamic relationship of eptazocine, a narcotic-antagonist analgesic, in rats.
Suzuki T, Shimizu R, Suganuma T, Nishino J, Tomono K, Hanano M, Watanabe J. Suzuki T, et al. Biol Pharm Bull. 2000 Dec;23(12):1504-10. doi: 10.1248/bpb.23.1504. Biol Pharm Bull. 2000. PMID: 11145186
The relationship between the pharmacokinetics and the pharmacodynamics of eptazocine, a narcotic-antagonist analgesic, was investigated in rats. ...Eptazocine produced a dose-dependent analgesic effect. It was demonstrated that eptazocine has a linear relatio …
The relationship between the pharmacokinetics and the pharmacodynamics of eptazocine, a narcotic-antagonist analgesic, was investigat …
Anesthetic management with eptazocine hydrobromide in patients receiving long-term antipsychotic medication.
Mizobe T, Oda Y, Natsuyama T, Miyazaki M. Mizobe T, et al. J Anesth. 1992 Jan;6(1):21-7. doi: 10.1007/s0054020060021. J Anesth. 1992. PMID: 15278579
Patients anesthetized with enflurane alone (enflurane group, n = 11), were compared with those anesthetized with enflurane and eptazocine hydrobromide 1 mg.kg(-1) (eptazocine group, n = 10). The mean daily dose of the antipsychotics, converted into the amount of chl …
Patients anesthetized with enflurane alone (enflurane group, n = 11), were compared with those anesthetized with enflurane and eptazocine …
A novel and practical asymmetric synthesis of eptazocine hydrobromide.
Li R, Liu Z, Chen L, Pan J, Lin K, Zhou W. Li R, et al. Beilstein J Org Chem. 2018 Sep 6;14:2340-2347. doi: 10.3762/bjoc.14.209. eCollection 2018. Beilstein J Org Chem. 2018. PMID: 30254698 Free PMC article.
In order to prepare eptazocine hydrobromide effectively, a novel, mild and practical asymmetric process was developed starting from 1-methyl-7-methoxy-2-tetralone under the catalysis of N-(p-trifluoromethylbenzyl)cinchonidinium bromide. ...
In order to prepare eptazocine hydrobromide effectively, a novel, mild and practical asymmetric process was developed starting from 1 …
[Protective effect of eptazocine, a novel analgesic, against cerebral hypoxia-anoxia in mice].
Tamura T, Taniguchi T, Aoki M, Waki I. Tamura T, et al. Nihon Yakurigaku Zasshi. 1990 Apr;95(4):167-75. doi: 10.1254/fpj.95.4_167. Nihon Yakurigaku Zasshi. 1990. PMID: 2370033 Japanese.
Cerebral protective effect of eptazocine, a mu-antagonist-kappa-agonist, was investigated using mice subjected to hypoxia-anoxia. ...The eptazocine effect was attenuated by either naloxone (5 mg/kg) or atropine (0.5 mg/kg), different from what was seen in the case o …
Cerebral protective effect of eptazocine, a mu-antagonist-kappa-agonist, was investigated using mice subjected to hypoxia-anoxia. ... …
Effects of eptazocine, a novel analgesic, on KCN-induced changes in the cerebral contents of glycolytic metabolites and high-energy phosphates in mice.
Tamura T, Taniguchi T, Miyamoto T, Aoki M, Waki I. Tamura T, et al. Jpn J Pharmacol. 1990 Oct;54(2):179-85. doi: 10.1254/jjp.54.179. Jpn J Pharmacol. 1990. PMID: 2077184 Free article.
Effects of eptazocine on cerebral metabolic changes due to a sublethal dose of KCN were investigated in mice. ...These results suggest that eptazocine may improve anoxic changes in cerebral energy metabolism....
Effects of eptazocine on cerebral metabolic changes due to a sublethal dose of KCN were investigated in mice. ...These results sugges …
[Pharmacological action of eptazocine (l-1,4-dimethyl-10-hydroxy-2,3,4,5,6,7-hexahydro-1,6-methano-1H-4-benz azonine). (V). A comparison of eptazocine, pentazocine and morphine with regard to ability of tolerance development after successive administration].
Nabeshima T, Yamada S, Kameyama T. Nabeshima T, et al. Nihon Yakurigaku Zasshi. 1986 Jun;87(6):619-27. doi: 10.1254/fpj.87.619. Nihon Yakurigaku Zasshi. 1986. PMID: 3744168 Japanese.
It was investigated whether tolerance to the pharmacological actions and cross-tolerance between eptazocine and pentazocine/morphine were developed by successive administration of eptazocine. ...On the tail flick method of rats, tolerance to the action of eptazoc …
It was investigated whether tolerance to the pharmacological actions and cross-tolerance between eptazocine and pentazocine/morphine …
[Preferential action of eptazocine, a novel analgesic, with opioid receptors in isolated guinea pig ileum and mouse vas deferens preparations].
Tamura T, Ogawa J, Taniguchi T, Waki I. Tamura T, et al. Nihon Yakurigaku Zasshi. 1990 Jan;95(1):41-6. doi: 10.1254/fpj.95.1_41. Nihon Yakurigaku Zasshi. 1990. PMID: 2154395 Japanese.
Actions of eptazocine, a novel analgesic, on isolated smooth muscle preparations were investigated. ...Eptazocine (10(-5)-10(-4) M) inhibited such an effect by the mu-agonist morphine. ...
Actions of eptazocine, a novel analgesic, on isolated smooth muscle preparations were investigated. ...Eptazocine (10(-5)-10(- …
Total intravenous anesthesia combined with epidural eptazocine.
Aida S, Tomiyama T, Shimoji K. Aida S, et al. J Anesth. 1995 Dec;9(4):311-7. doi: 10.1007/BF02479943. J Anesth. 1995. PMID: 23839878
To reduce the doses of intravenous anesthetics (ketamine, diazepam, droperidol, and vecuronium) used in total intravenous anesthesia (TIVA), epidural administration of a -stimulating opioid, eptazocine, was combined with TIVA in 115 patients. Surgical procedures were uneve …
To reduce the doses of intravenous anesthetics (ketamine, diazepam, droperidol, and vecuronium) used in total intravenous anesthesia (TIVA), …
Comparison of circulatory and respiratory responses between supplementary epidural buprenorphine and eptazocine administration during and immediately after total intravenous anesthesia.
Aida S, Baba H, Shimoji K. Aida S, et al. J Anesth. 1997 Jun;11(2):94-9. doi: 10.1007/BF02480068. J Anesth. 1997. PMID: 23839678
Buprenorphine has a strong mu-action with a minute -action, while eptazocine stimulates -receptors only. From these, epidural eptazocine is expected to exert strong spinal analgesia by -stimulation without mu-action, which produces circulatory and respiratory depres …
Buprenorphine has a strong mu-action with a minute -action, while eptazocine stimulates -receptors only. From these, epidural epta …
Antinociceptive activity of intracisternally and intrathecally administered eptazocine, a novel analgesic, in mice.
Aoki M, Kaneko S, Watanabe H. Aoki M, et al. Methods Find Exp Clin Pharmacol. 1990 Jan-Feb;12(1):11-5. Methods Find Exp Clin Pharmacol. 1990. PMID: 2314148
The rank order of potency for inhibition of writhing after intracisternal administration was morphine greater than eptazocine greater than pentazocine. In contrast, the intrathecal compounds inhibited writhing with a rank order of potency of eptazocine greater than …
The rank order of potency for inhibition of writhing after intracisternal administration was morphine greater than eptazocine greater …
33 results