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116 results

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Quoted phrase not found in phrase index: "Escape Beyond Mid-Chin"
Page 1
Roles of PD-1/PD-L1 Pathway: Signaling, Cancer, and Beyond.
Ai L, Xu A, Xu J. Ai L, et al. Adv Exp Med Biol. 2020;1248:33-59. doi: 10.1007/978-981-15-3266-5_3. Adv Exp Med Biol. 2020. PMID: 32185706 Review.
Bodies evolve coinhibitory pathways controlling T cell response magnitude and duration to limit tissue damage and maintain self-tolerance. However, tumor cells hijack these inhibitory pathways to escape host immune surveillance by overexpression of PD-L1. This provides the …
Bodies evolve coinhibitory pathways controlling T cell response magnitude and duration to limit tissue damage and maintain self-tolerance. H …
Tertiary lymphoid structures in cancer and beyond.
Dieu-Nosjean MC, Goc J, Giraldo NA, Sautès-Fridman C, Fridman WH. Dieu-Nosjean MC, et al. Trends Immunol. 2014 Nov;35(11):571-80. doi: 10.1016/j.it.2014.09.006. Epub 2014 Oct 22. Trends Immunol. 2014. PMID: 25443495 Review.
We examine the relationship between TLS in tumors and patient prognosis, and discuss the potential role of TLS in building and/or maintaining local immune responses and how this understanding may guide therapeutic interventions....
We examine the relationship between TLS in tumors and patient prognosis, and discuss the potential role of TLS in building and/or mai …
The immune contexture in cancer prognosis and treatment.
Fridman WH, Zitvogel L, Sautès-Fridman C, Kroemer G. Fridman WH, et al. Nat Rev Clin Oncol. 2017 Dec;14(12):717-734. doi: 10.1038/nrclinonc.2017.101. Epub 2017 Jul 25. Nat Rev Clin Oncol. 2017. PMID: 28741618 Review.
As a result, the immune contexture, which is determined by the density, composition, functional state and organization of the leukocyte infiltrate of the tumour, can yield information that is relevant to prognosis, prediction of a treatment response and various othe …
As a result, the immune contexture, which is determined by the density, composition, functional state and organization of the leukocyte infi …
Cancer-cell-derived GABA promotes β-catenin-mediated tumour growth and immunosuppression.
Huang D, Wang Y, Thompson JW, Yin T, Alexander PB, Qin D, Mudgal P, Wu H, Liang Y, Tan L, Pan C, Yuan L, Wan Y, Li QJ, Wang XF. Huang D, et al. Nat Cell Biol. 2022 Feb;24(2):230-241. doi: 10.1038/s41556-021-00820-9. Epub 2022 Feb 10. Nat Cell Biol. 2022. PMID: 35145222 Free PMC article.
An analysis of clinical samples reveals that increased GABA levels predict poor prognosis. Mechanistically, we identify a cancer-intrinsic pathway through which GABA activates the GABA(B) receptor to inhibit GSK-3beta activity, leading to enhanced beta-catenin signa …
An analysis of clinical samples reveals that increased GABA levels predict poor prognosis. Mechanistically, we identify a canc …
Effect of Physical Therapy vs Arthroscopic Partial Meniscectomy in People With Degenerative Meniscal Tears: Five-Year Follow-up of the ESCAPE Randomized Clinical Trial.
Noorduyn JCA, van de Graaf VA, Willigenburg NW, Scholten-Peeters GGM, Kret EJ, van Dijk RA, Buchbinder R, Hawker GA, Coppieters MW, Poolman RW; ESCAPE Research Group. Noorduyn JCA, et al. JAMA Netw Open. 2022 Jul 1;5(7):e2220394. doi: 10.1001/jamanetworkopen.2022.20394. JAMA Netw Open. 2022. PMID: 35802374 Free PMC article. Clinical Trial.
Intergenerational Interdependence of Labour Market Careers.
Brydsten A, Baranowska-Rataj A. Brydsten A, et al. Adv Life Course Res. 2022 Dec;54:100513. doi: 10.1016/j.alcr.2022.100513. Epub 2022 Sep 6. Adv Life Course Res. 2022. PMID: 36651620
However, little is known about the intergenerational transmission for those who manage to escape from precariousness, and how the transmission of labour market disadvantage operates depending on the gender structure of parent-child dyads. ...
However, little is known about the intergenerational transmission for those who manage to escape from precariousness, and how the tra …
Beyond Sequencing: Prioritizing and Delivering Neoantigens for Cancer Vaccines.
Roesler AS, Anderson KS. Roesler AS, et al. Methods Mol Biol. 2022;2410:649-670. doi: 10.1007/978-1-0716-1884-4_35. Methods Mol Biol. 2022. PMID: 34914074 Review.
Cancer vaccines are similarly designed to elicit or amplify antigen-specific T cell populations and stimulate directed antitumor immunity, but the selection and prioritization of the neoantigens remains a challenge. Bioinformatic algorithms can predict tumor neoantigens fr …
Cancer vaccines are similarly designed to elicit or amplify antigen-specific T cell populations and stimulate directed antitumor immunity, b …
Genomic alterations underlying immune privilege in malignant lymphomas.
Mottok A, Steidl C. Mottok A, et al. Curr Opin Hematol. 2015 Jul;22(4):343-54. doi: 10.1097/MOH.0000000000000155. Curr Opin Hematol. 2015. PMID: 26049756 Review.
SUMMARY: Further investigations will foster our understanding about synergy of immune escape mechanisms, and lay the foundation for the development of predictive biomarkers in the context of conceptually novel therapies targeting microenvironment-related biology, su …
SUMMARY: Further investigations will foster our understanding about synergy of immune escape mechanisms, and lay the foundation for t …
Tumor innervation: peripheral nerves take control of the tumor microenvironment.
Gysler SM, Drapkin R. Gysler SM, et al. J Clin Invest. 2021 Jun 1;131(11):e147276. doi: 10.1172/JCI147276. J Clin Invest. 2021. PMID: 34060481 Free PMC article. Review.
This process, termed tumor innervation, is associated with an aggressive tumor phenotype and correlates with poor prognosis in clinical studies. Therefore, the peripheral nervous system may play an underrecognized role in cancer development, harboring targetable pathways t …
This process, termed tumor innervation, is associated with an aggressive tumor phenotype and correlates with poor prognosis in clinic …
Pharmacotherapy for treating metastatic clear cell renal cell carcinoma.
Porta C, Chiellino S, Ferrari A, Mariucci S, Liguigli W. Porta C, et al. Expert Opin Pharmacother. 2017 Feb;18(2):205-216. doi: 10.1080/14656566.2017.1282462. Expert Opin Pharmacother. 2017. PMID: 28103447 Review.
Over the past decade metastatic renal cell carcinoma (RCC) treatment landscape has dramatically evolved from the era of cytokines-based immunotherapy (which benefited very few patients, at the expenses of high toxicities) to the present era of targeted agents and novel immunother …
Over the past decade metastatic renal cell carcinoma (RCC) treatment landscape has dramatically evolved from the era of cytokines-based immu …
116 results