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Metabolomic signatures associated with depression and predictors of antidepressant response in humans: A CAN-BIND-1 report.
Caspani G, Turecki G, Lam RW, Milev RV, Frey BN, MacQueen GM, Müller DJ, Rotzinger S, Kennedy SH, Foster JA, Swann JR. Caspani G, et al. Commun Biol. 2021 Jul 22;4(1):903. doi: 10.1038/s42003-021-02421-6. Commun Biol. 2021. PMID: 34294869 Free PMC article.
For treatment response, lower baseline concentrations of apolipoprotein A1 and HDL were predictive of escitalopram response in males, while higher baseline concentrations of apolipoprotein A2, HDL and VLDL subfractions were predictive of aripiprazole response in fem …
For treatment response, lower baseline concentrations of apolipoprotein A1 and HDL were predictive of escitalopram response in males, …
Clinical, behavioral, and neural measures of reward processing correlate with escitalopram response in depression: a Canadian Biomarker Integration Network in Depression (CAN-BIND-1) Report.
Dunlop K, Rizvi SJ, Kennedy SH, Hassel S, Strother SC, Harris JK, Zamyadi M, Arnott SR, Davis AD, Mansouri F, Schulze L, Ceniti AK, Lam RW, Milev R, Rotzinger S, Foster JA, Frey BN, Parikh SV, Soares CN, Uher R, Turecki G, MacQueen GM, Downar J. Dunlop K, et al. Neuropsychopharmacology. 2020 Jul;45(8):1390-1397. doi: 10.1038/s41386-020-0688-x. Neuropsychopharmacology. 2020. PMID: 32349119 Free PMC article.
More severe anhedonia in major depressive disorder (MDD) is a negative predictor of antidepressant response. It is unknown, however, whether the pathophysiology of anhedonia represents a viable avenue for identifying biological markers of antidepressant treatment response. …
More severe anhedonia in major depressive disorder (MDD) is a negative predictor of antidepressant response. It is unknown, however, …
Tumor necrosis factor and its targets in the inflammatory cytokine pathway are identified as putative transcriptomic biomarkers for escitalopram response.
Powell TR, Schalkwyk LC, Heffernan AL, Breen G, Lawrence T, Price T, Farmer AE, Aitchison KJ, Craig IW, Danese A, Lewis C, McGuffin P, Uher R, Tansey KE, D'Souza UM. Powell TR, et al. Eur Neuropsychopharmacol. 2013 Sep;23(9):1105-14. doi: 10.1016/j.euroneuro.2012.09.009. Epub 2012 Nov 9. Eur Neuropsychopharmacol. 2013. PMID: 23142150 Clinical Trial.
The current study adds substantial support for the role of the inflammatory cytokine pathway in mediating response to the SSRI escitalopram, and is the first to identify TNF and its targets as putative transcriptomic predictors of clinical response....
The current study adds substantial support for the role of the inflammatory cytokine pathway in mediating response to the SSRI escitalopram, …
Pre-treatment factor structures of the Montgomery and Asberg Depression Rating scale as predictors of response to escitalopram in Indian patients with non-psychotic major depressive disorder.
Basu A, Chadda R, Sood M, Rizwan SA. Basu A, et al. Asian J Psychiatr. 2017 Aug;28:154-159. doi: 10.1016/j.ajp.2017.04.029. Epub 2017 May 15. Asian J Psychiatr. 2017. PMID: 28784374
At the end of the treatment there were significant changes in all the 4 factor structures (p<0.01). Vegetative function was an important predictor of response (p<0.01, odd's ratio: 1.3 [1.1-1.6] 95% CI). ...Understanding the factor structure is important as they can …
At the end of the treatment there were significant changes in all the 4 factor structures (p<0.01). Vegetative function was an important …
Pharmacogenetic Study of Serotonin Transporter and 5HT2A Genotypes in Autism.
Najjar F, Owley T, Mosconi MW, Jacob S, Hur K, Guter SJ, Sweeney JA, Gibbons RD, Cook EH, Bishop JR. Najjar F, et al. J Child Adolesc Psychopharmacol. 2015 Aug;25(6):467-74. doi: 10.1089/cap.2014.0158. J Child Adolesc Psychopharmacol. 2015. PMID: 26262902 Free PMC article. Clinical Trial.
RESULTS: Insistence on sameness and irritability symptoms significantly improved over the course of the 6 week treatment period (p<0.0001) in this open-label trial. ...
RESULTS: Insistence on sameness and irritability symptoms significantly improved over the course of the 6 week treatment period (p&lt …