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Tau oligomer induced HMGB1 release contributes to cellular senescence and neuropathology linked to Alzheimer's disease and frontotemporal dementia.
Gaikwad S, Puangmalai N, Bittar A, Montalbano M, Garcia S, McAllen S, Bhatt N, Sonawane M, Sengupta U, Kayed R. Gaikwad S, et al. Cell Rep. 2021 Jul 20;36(3):109419. doi: 10.1016/j.celrep.2021.109419. Cell Rep. 2021. PMID: 34289368 Free PMC article.
Aging, pathological tau oligomers (TauO), and chronic inflammation in the brain play a central role in tauopathies, including Alzheimer's disease (AD) and frontotemporal dementia (FTD). However, the underlying mechanism of TauO-induced aging-related neuroinflammatio …
Aging, pathological tau oligomers (TauO), and chronic inflammation in the brain play a central role in tauopathies, including Alzheimer …
Neuroprotective Effects of Ethyl Pyruvate against Aluminum Chloride-Induced Alzheimer's Disease in Rats via Inhibiting Toll-Like Receptor 4.
Chavali VD, Agarwal M, Vyas VK, Saxena B. Chavali VD, et al. J Mol Neurosci. 2020 Jun;70(6):836-850. doi: 10.1007/s12031-020-01489-9. Epub 2020 Feb 6. J Mol Neurosci. 2020. PMID: 32030557
The present study aimed to investigate the neuroprotective role of ethyl pyruvate against in vitro and in vivo model of aluminum chloride (AlCl(3))-induced AD. ...Ethyl pyruvate showed a docking score of 4.048. Thus, ethyl pyruvate is eff …
The present study aimed to investigate the neuroprotective role of ethyl pyruvate against in vitro and in vivo model of alumin …
Ethyl Pyruvate Attenuates Microglial NLRP3 Inflammasome Activation via Inhibition of HMGB1/NF-kappaB/miR-223 Signaling.
Olcum M, Tufekci KU, Durur DY, Tastan B, Gokbayrak IN, Genc K, Genc S. Olcum M, et al. Antioxidants (Basel). 2021 May 8;10(5):745. doi: 10.3390/antiox10050745. Antioxidants (Basel). 2021. PMID: 34066647 Free PMC article.
Ethyl pyruvate is a molecule with anti-inflammatory and pro-metabolic effects. Ethyl pyruvate has been shown to ameliorate the clinical and pathological findings of neurodegenerative diseases such as Alzheimer's and Parkinson's Diseases i …
Ethyl pyruvate is a molecule with anti-inflammatory and pro-metabolic effects. Ethyl pyruvate has been shown to …
Transglutaminase 2 expression induced by lipopolysaccharide stimulation together with NO synthase induction in cultured astrocytes.
Takano K, Shiraiwa K, Moriyama M, Nakamura Y. Takano K, et al. Neurochem Int. 2010 Dec;57(7):812-8. doi: 10.1016/j.neuint.2010.08.019. Epub 2010 Sep 9. Neurochem Int. 2010. PMID: 20817067
Activation of glia has been observed in neurodegenerative diseases such as Parkinson's disease (PD), Alzheimer's disease (AD), multiple sclerosis and brain ischemia. Excessive production of nitric oxide (NO), as a consequence of increased inducible NO synthase (iNOS …
Activation of glia has been observed in neurodegenerative diseases such as Parkinson's disease (PD), Alzheimer's disease (AD), …
High mobility group box 1 in the central nervous system: regeneration hidden beneath inflammation.
Kim H, Kim BJ, Koh S, Cho HJ, Jin X, Kim BG, Choi JY. Kim H, et al. Neural Regen Res. 2025 Jan 1;20(1):107-115. doi: 10.4103/NRR.NRR-D-23-01964. Epub 2024 Apr 3. Neural Regen Res. 2025. PMID: 38767480 Free article.
High-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern, which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke, Alzheimer's disea …
High-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern, which has been pro …