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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1987 1
1990 6
1991 7
1992 11
1993 20
1994 28
1995 24
1996 39
1997 36
1998 51
1999 46
2000 54
2001 47
2002 61
2003 64
2004 76
2005 85
2006 78
2007 80
2008 68
2009 83
2010 79
2011 81
2012 80
2013 100
2014 134
2015 124
2016 138
2017 140
2018 128
2019 138
2020 150
2021 178
2022 158
2023 172
2024 62

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1,268 results

Results by year

Filters applied: Meta-Analysis, Review, Systematic Review, in the last 10 years. Clear all
Page 1
Molecular mechanisms of ischemia and glutamate excitotoxicity.
Neves D, Salazar IL, Almeida RD, Silva RM. Neves D, et al. Life Sci. 2023 Sep 1;328:121814. doi: 10.1016/j.lfs.2023.121814. Epub 2023 May 24. Life Sci. 2023. PMID: 37236602 Free article. Review.
Excitotoxicity is classically defined as the neuronal damage caused by the excessive release of glutamate, and subsequent activation of excitatory plasma membrane receptors. ...Here, we review the current knowledge on the molecular mechanisms that underlie excitotoxicit …
Excitotoxicity is classically defined as the neuronal damage caused by the excessive release of glutamate, and subsequent activation …
Glutamate-induced excitotoxicity in Parkinson's disease: The role of glial cells.
Iovino L, Tremblay ME, Civiero L. Iovino L, et al. J Pharmacol Sci. 2020 Nov;144(3):151-164. doi: 10.1016/j.jphs.2020.07.011. Epub 2020 Aug 1. J Pharmacol Sci. 2020. PMID: 32807662 Free article. Review.
Indeed, extracellular glutamate increase causes aberrant synaptic signaling leading to neuronal excitotoxicity and death. Moreover, extrasynaptic glutamate diffusion is strongly associated with glia reaction and neuroinflammation. ...In this review, we discuss the function …
Indeed, extracellular glutamate increase causes aberrant synaptic signaling leading to neuronal excitotoxicity and death. Moreover, e …
Glutamate excitotoxicity: Potential therapeutic target for ischemic stroke.
Shen Z, Xiang M, Chen C, Ding F, Wang Y, Shang C, Xin L, Zhang Y, Cui X. Shen Z, et al. Biomed Pharmacother. 2022 Jul;151:113125. doi: 10.1016/j.biopha.2022.113125. Epub 2022 May 24. Biomed Pharmacother. 2022. PMID: 35609367 Free article. Review.
Glutamate-mediated excitotoxicity is an important mechanism leading to post ischemic stroke damage. ...
Glutamate-mediated excitotoxicity is an important mechanism leading to post ischemic stroke damage. ...
Excitotoxicity, calcium and mitochondria: a triad in synaptic neurodegeneration.
Verma M, Lizama BN, Chu CT. Verma M, et al. Transl Neurodegener. 2022 Jan 25;11(1):3. doi: 10.1186/s40035-021-00278-7. Transl Neurodegener. 2022. PMID: 35078537 Free PMC article. Review.
Glutamate is the most commonly engaged neurotransmitter in the mammalian central nervous system, acting to mediate excitatory neurotransmission. However, high levels of glutamatergic input elicit excitotoxicity, contributing to neuronal cell death following acute brain inj …
Glutamate is the most commonly engaged neurotransmitter in the mammalian central nervous system, acting to mediate excitatory neurotransmiss …
Calcium Permeable-AMPA Receptors and Excitotoxicity in Neurological Disorders.
Guo C, Ma YY. Guo C, et al. Front Neural Circuits. 2021 Aug 17;15:711564. doi: 10.3389/fncir.2021.711564. eCollection 2021. Front Neural Circuits. 2021. PMID: 34483848 Free PMC article. Review.
Excitotoxicity is one of the primary mechanisms of cell loss in a variety of diseases of the central and peripheral nervous systems. Other than the previously established signaling pathways of excitotoxicity, which depend on the excessive release of glutamate from a …
Excitotoxicity is one of the primary mechanisms of cell loss in a variety of diseases of the central and peripheral nervous systems. …
Neuroprotection in acute stroke: targeting excitotoxicity, oxidative and nitrosative stress, and inflammation.
Chamorro Á, Dirnagl U, Urra X, Planas AM. Chamorro Á, et al. Lancet Neurol. 2016 Jul;15(8):869-881. doi: 10.1016/S1474-4422(16)00114-9. Epub 2016 May 11. Lancet Neurol. 2016. PMID: 27180033 Review.
Randomised controlled trials of combination treatments completed within the past 5 years have included growth factors, hypothermia, minocycline, natalizumab, fingolimod, and uric acid; the latter two drugs with alteplase produced encouraging results. Blocking of excitotoxicity …
Randomised controlled trials of combination treatments completed within the past 5 years have included growth factors, hypothermia, minocycl …
Excitotoxicity as a Target Against Neurodegenerative Processes.
Binvignat O, Olloquequi J. Binvignat O, et al. Curr Pharm Des. 2020;26(12):1251-1262. doi: 10.2174/1381612826666200113162641. Curr Pharm Des. 2020. PMID: 31931694 Review.
Although the molecular mechanisms leading to neurodegeneration are not completely understood, excitotoxicity, defined as the injury and death of neurons due to excessive or prolonged exposure to excitatory amino acids, has been shown to play a pivotal role. ...
Although the molecular mechanisms leading to neurodegeneration are not completely understood, excitotoxicity, defined as the injury a …
Excitotoxicity: Still Hammering the Ischemic Brain in 2020.
Choi DW. Choi DW. Front Neurosci. 2020 Oct 26;14:579953. doi: 10.3389/fnins.2020.579953. eCollection 2020. Front Neurosci. 2020. PMID: 33192266 Free PMC article. Review.
Interest in excitotoxicity expanded following its implication in the pathogenesis of ischemic brain injury in the 1980s, but waned subsequent to the failure of N-methyl-D-aspartate (NMDA) antagonists in high profile clinical stroke trials. ...This review will outline the h …
Interest in excitotoxicity expanded following its implication in the pathogenesis of ischemic brain injury in the 1980s, but waned su …
Excitotoxicity Revisited: Mitochondria on the Verge of a Nervous Breakdown.
Plotegher N, Filadi R, Pizzo P, Duchen MR. Plotegher N, et al. Trends Neurosci. 2021 May;44(5):342-351. doi: 10.1016/j.tins.2021.01.001. Epub 2021 Feb 16. Trends Neurosci. 2021. PMID: 33608137 Review.
Excitotoxicity is likely to occur in pathological scenarios in which mitochondrial function is already compromised, shaping neuronal responses to glutamate. ...Here, we suggest the need to explore glutamate toxicity in the context of specific disease models in which it may …
Excitotoxicity is likely to occur in pathological scenarios in which mitochondrial function is already compromised, shaping neuronal …
TRP Channels in Excitotoxicity.
Zong P, Legere N, Feng J, Yue L. Zong P, et al. Neuroscientist. 2024 Apr 29:10738584241246530. doi: 10.1177/10738584241246530. Online ahead of print. Neuroscientist. 2024. PMID: 38682490 Review.
However, almost all the glutamate receptor antagonists failed to attenuate excitotoxicity in human patients, mainly due to the limited understanding of the underlying mechanisms regulating excitotoxicity. ...These channels have been found to play pivotal roles in nu …
However, almost all the glutamate receptor antagonists failed to attenuate excitotoxicity in human patients, mainly due to the limite …
1,268 results