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Table representation of search results timeline featuring number of search results per year.

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Page 1
Polygenic risk scores in familial Alzheimer disease.
Tosto G, Bird TD, Tsuang D, Bennett DA, Boeve BF, Cruchaga C, Faber K, Foroud TM, Farlow M, Goate AM, Bertlesen S, Graff-Radford NR, Medrano M, Lantigua R, Manly J, Ottman R, Rosenberg R, Schaid DJ, Schupf N, Stern Y, Sweet RA, Mayeux R. Tosto G, et al. Neurology. 2017 Mar 21;88(12):1180-1186. doi: 10.1212/WNL.0000000000003734. Epub 2017 Feb 17. Neurology. 2017. PMID: 28213371 Free PMC article.
OBJECTIVE: To investigate the association between a genetic risk score (GRS) and familial late-onset Alzheimer disease (LOAD) and its predictive value in families multiply affected by the disease. METHODS: Using data from the National Institute on Aging Genetics Initiative …
OBJECTIVE: To investigate the association between a genetic risk score (GRS) and familial late-onset Alzheimer disease (LOAD) and its pre …
Insights into Alzheimer disease pathogenesis from studies in transgenic animal models.
Schaeffer EL, Figueiro M, Gattaz WF. Schaeffer EL, et al. Clinics (Sao Paulo). 2011;66 Suppl 1(Suppl 1):45-54. doi: 10.1590/s1807-59322011001300006. Clinics (Sao Paulo). 2011. PMID: 21779722 Free PMC article. Review.
At present there is no effective treatment for Alzheimer disease. Given the prevalence and poor prognosis of the disease, the development of animal models has been a research priority to understand pathogenic mechanisms and to test therapeutic strategies. ...
At present there is no effective treatment for Alzheimer disease. Given the prevalence and poor prognosis of the disease, the develop …
Retinal Imaging Findings in Carriers With PSEN1-Associated Early-Onset Familial Alzheimer Disease Before Onset of Cognitive Symptoms.
Armstrong GW, Kim LA, Vingopoulos F, Park JY, Garg I, Kasetty M, Silverman RF, Zeng R, Douglas VP, Lopera F, Baena A, Giraldo M, Norton D, Cronin-Golomb A, Arboleda-Velasquez JF, Quiroz YT, Miller JB. Armstrong GW, et al. JAMA Ophthalmol. 2021 Jan 1;139(1):49-56. doi: 10.1001/jamaophthalmol.2020.4909. JAMA Ophthalmol. 2021. PMID: 33180114 Free PMC article.
Evolutionary History of Alzheimer Disease-Causing Protein Family Presenilins with Pathological Implications.
Khan AA, Ali RH, Mirza B. Khan AA, et al. J Mol Evol. 2020 Nov;88(8-9):674-688. doi: 10.1007/s00239-020-09966-w. Epub 2020 Oct 1. J Mol Evol. 2020. PMID: 33001284
We also demonstrate that Presenilin proteins generally lack diversifying selection during the course of their evolution. Through evolutionary trace analysis, we show that Presenilin protein sites that undergo mutations in Familial Alzheimer disease, are highly conserved in …
We also demonstrate that Presenilin proteins generally lack diversifying selection during the course of their evolution. Through evol …
The pattern of atrophy in familial Alzheimer disease: volumetric MRI results from the DIAN study.
Cash DM, Ridgway GR, Liang Y, Ryan NS, Kinnunen KM, Yeatman T, Malone IB, Benzinger TL, Jack CR Jr, Thompson PM, Ghetti BF, Saykin AJ, Masters CL, Ringman JM, Salloway SP, Schofield PR, Sperling RA, Cairns NJ, Marcus DS, Xiong C, Bateman RJ, Morris JC, Rossor MN, Ourselin S, Fox NC; Dominantly Inherited Alzheimer Network (DIAN). Cash DM, et al. Neurology. 2013 Oct 15;81(16):1425-33. doi: 10.1212/WNL.0b013e3182a841c6. Epub 2013 Sep 18. Neurology. 2013. PMID: 24049139 Free PMC article.
Presymptomatic cortical thinning in familial Alzheimer disease: A longitudinal MRI study.
Weston PS, Nicholas JM, Lehmann M, Ryan NS, Liang Y, Macpherson K, Modat M, Rossor MN, Schott JM, Ourselin S, Fox NC. Weston PS, et al. Neurology. 2016 Nov 8;87(19):2050-2057. doi: 10.1212/WNL.0000000000003322. Epub 2016 Oct 12. Neurology. 2016. PMID: 27733562 Free PMC article.
There were significant differences in mean cortical signature thickness between mutation carriers and controls 3 years before predicted symptom onset. The earliest significant difference in a single region, detectable 4 years preonset, was in the precuneus. Rate of change …
There were significant differences in mean cortical signature thickness between mutation carriers and controls 3 years before predicted …
MRS shows abnormalities before symptoms in familial Alzheimer disease.
Godbolt AK, Waldman AD, MacManus DG, Schott JM, Frost C, Cipolotti L, Fox NC, Rossor MN. Godbolt AK, et al. Neurology. 2006 Mar 14;66(5):718-22. doi: 10.1212/01.wnl.0000201237.05869.df. Neurology. 2006. PMID: 16534109
PMC subjects were 1.7 to 21.6 years (mean 9.8 years) before expected symptom onset, predicted from family-specific mean age at onset. Age did not significantly affect metabolite ratios. ...
PMC subjects were 1.7 to 21.6 years (mean 9.8 years) before expected symptom onset, predicted from family-specific mean age at onset. …
Identification and expression analysis of a potential familial Alzheimer disease gene on chromosome 1 related to AD3.
Li J, Ma J, Potter H. Li J, et al. Proc Natl Acad Sci U S A. 1995 Dec 19;92(26):12180-4. doi: 10.1073/pnas.92.26.12180. Proc Natl Acad Sci U S A. 1995. PMID: 8618867 Free PMC article.
This gene is located on chromosome 1, is expressed in a variety of tissues, including brain, and is predicted to harbor mutations causing nonchromosome 14 familial AD. ...
This gene is located on chromosome 1, is expressed in a variety of tissues, including brain, and is predicted to harbor mutations cau …
Early diagnosis of Alzheimer disease with positron emission tomography.
Jelic V, Nordberg A. Jelic V, et al. Alzheimer Dis Assoc Disord. 2000;14 Suppl 1:S109-13. doi: 10.1097/00002093-200000001-00016. Alzheimer Dis Assoc Disord. 2000. PMID: 10850738 Review.
The emergence of drugs that may slow progression of Alzheimer disease, if administered early during its course, has necessitated early diagnosis of the disease itself. Among the functional imaging methods that could assist in early diagnosis, positron emission tomography h …
The emergence of drugs that may slow progression of Alzheimer disease, if administered early during its course, has necessitated earl …
Interaction of ApoE3 and ApoE4 isoforms with an ITM2b/BRI2 mutation linked to the Alzheimer disease-like Danish dementia: Effects on learning and memory.
Biundo F, Ishiwari K, Del Prete D, D'Adamio L. Biundo F, et al. Neurobiol Learn Mem. 2015 Dec;126:18-30. doi: 10.1016/j.nlm.2015.10.009. Epub 2015 Oct 31. Neurobiol Learn Mem. 2015. PMID: 26528887 Free PMC article.
Three major variants of ApoE exist in humans (ApoE2, ApoE3, and ApoE4), with the ApoE4 allele being strongly associated with AD. ITM2b/BRI2 is also a candidate regulatory node genes predicted to mediate the common patterns of gene expression shared by healthy ApoE4 carrier …
Three major variants of ApoE exist in humans (ApoE2, ApoE3, and ApoE4), with the ApoE4 allele being strongly associated with AD. ITM2b/BRI2 …
31 results