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Gonadotrophin receptors.
Clayton RN. Clayton RN. Baillieres Clin Endocrinol Metab. 1996 Jan;10(1):1-8. doi: 10.1016/s0950-351x(96)80250-3. Baillieres Clin Endocrinol Metab. 1996. PMID: 8734448 Review.
Precocious puberty may be gonadotrophin-dependent, due to premature activation of the hypothalamic GnRH pulse generator, or gonadotrophin-independent wherein serum LH and FSH levels are undetectable despite near-adult levels of gonadal steroidogenesis. In one form of gonadotrophi …
Precocious puberty may be gonadotrophin-dependent, due to premature activation of the hypothalamic GnRH pulse generator, or gonadotrophin-in …
Growing Up Fast: Managing Autism Spectrum Disorder and Precocious Puberty.
Finkle A, Zavertnik S, Myers S, Cormier D, Heithaus J, Augustyn M. Finkle A, et al. J Dev Behav Pediatr. 2020 Dec;41(9):740-742. doi: 10.1097/DBP.0000000000000865. J Dev Behav Pediatr. 2020. PMID: 33214411
John was concurrently evaluated by a pediatric endocrinologist at 34 months. At that assessment, his height Z-score was +2.5, and he had Tanner 2 pubic hair, Tanner 3 genitalia, and 6 cc testicular volumes. ...A constitutively activating mutation of the luteinizing hormone …
John was concurrently evaluated by a pediatric endocrinologist at 34 months. At that assessment, his height Z-score was +2.5, and he …
Treatment of familial male precocious puberty with spironolactone and testolactone.
Laue L, Kenigsberg D, Pescovitz OH, Hench KD, Barnes KM, Loriaux DL, Cutler GB Jr. Laue L, et al. N Engl J Med. 1989 Feb 23;320(8):496-502. doi: 10.1056/NEJM198902233200805. N Engl J Med. 1989. PMID: 2492636
Because the pubertal growth spurt in boys appears to be mediated by both androgens and estrogens, we hypothesized that blockade of both androgen action and estrogen synthesis would normalize the growth of boys with familial male precocious puberty. To …
Because the pubertal growth spurt in boys appears to be mediated by both androgens and estrogens, we hypothesized that blockade of both andr …
Effect of Antiandrogen, Aromatase Inhibitor, and Gonadotropin-releasing Hormone Analog on Adult Height in Familial Male Precocious Puberty.
Leschek EW, Flor AC, Bryant JC, Jones JV, Barnes KM, Cutler GB Jr. Leschek EW, et al. J Pediatr. 2017 Nov;190:229-235. doi: 10.1016/j.jpeds.2017.07.047. J Pediatr. 2017. PMID: 29144249 Free PMC article. Clinical Trial.

RESULTS: AH (mean SD) for all treated subjects was 173.6 6.8 cm (-0.4 1.0 SD relative to adult US males). For 25 subjects with pretreatment predicted AH, AH significantly exceeded predicted AH at treatment onset (173.8 6.9 vs 164.9 10.7 cm; P < .001), but fell sh

…
RESULTS: AH (mean SD) for all treated subjects was 173.6 6.8 cm (-0.4 1.0 SD relative to adult US males). For 25 subjects with pretreatment …
Use of aromatase inhibitors in precocious puberty.
Feuillan P, Merke D, Leschek EW, Cutler GB Jr. Feuillan P, et al. Endocr Relat Cancer. 1999 Jun;6(2):303-6. doi: 10.1677/erc.0.0060303. Endocr Relat Cancer. 1999. PMID: 10731123 Review.
In a 6-month pilot study of 12 children (eight boys; four girls) with congenital adrenal hyperplasia, testolactone, in combination with an antiandrogen (flutamide), a mineralocorticoid (fludrocortisone acetate, Florinef), and a reduced glucocorticoid dose, improved the control of …
In a 6-month pilot study of 12 children (eight boys; four girls) with congenital adrenal hyperplasia, testolactone, in combination with an a …
Body image in adolescents with disorders of steroidogenesis.
Ning C, Green-Golan L, Stratakis CA, Leschek E, Sinaii N, Schroth E, Ernst M, Merke DP. Ning C, et al. J Pediatr Endocrinol Metab. 2008 Aug;21(8):771-80. doi: 10.1515/jpem.2008.21.8.771. J Pediatr Endocrinol Metab. 2008. PMID: 18825877 Free PMC article.
We evaluated body image in children with congenital adrenal hyperplasia (CAH), familial male precocious puberty (FMPP), and Cushing's syndrome (CS). ...Unhappiness with height and age of appearance was similar between groups. In female patients, higher …
We evaluated body image in children with congenital adrenal hyperplasia (CAH), familial male precocious puberty …
Long-term follow-up of spontaneous development in a boy with familial male precocious puberty.
Partsch CJ, Krone N, Riepe FG, Gromoll J, Sippell WG. Partsch CJ, et al. Horm Res. 2004;62(4):177-81. doi: 10.1159/000080887. Epub 2004 Sep 15. Horm Res. 2004. PMID: 15375328
BACKGROUND/AIMS: Limited data are available about spontaneous growth, pubertal growth spurt and the long-term outcome of patients suffering from familial male precocious puberty (FMPP). We report on a boy with FMPP whose growth pattern and pubertal dev …
BACKGROUND/AIMS: Limited data are available about spontaneous growth, pubertal growth spurt and the long-term outcome of patients suffering …